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PUROMYCIN AMINONUCLEOSIDE

PUROMYCIN AMINONUCLEOSIDE ??? ???
?? ??:
58-60-6
???:
PUROMYCIN AMINONUCLEOSIDE
???(??):
ARDMA;Nsc3056;Aids000507;Aids-000507;aminonucleoside;3′-Amino-3′-deoxy-N6;aminonucleosidepuromycin;PuroMycin aMinonucleosid;PUROMYCIN AMINONUCLEOSIDE;stylomycinaminonucleoside
CBNumber:
CB5455647
???:
C12H18N6O3
??? ??:
294.31
MOL ??:
58-60-6.mol

PUROMYCIN AMINONUCLEOSIDE ??

???
235℃ (Decomposition)
?? ?
436.08°C (rough estimate)
??
1.2131 (rough estimate)
???
1.7000 (estimate)
???
>110°(230°F)
?? ??
Keep in dark place,Inert atmosphere,2-8°C
???
H2O: 50 mg/mL, ??, ?? ???
??? ??
??
?? ?? (pKa)
13.26±0.70(Predicted)
??
???
???
50mg/ml? ?? ?????. ??? ??? ? ??
BRN
93902
???
??? ?? 1? ?? ??????. DMSO ?? ??? ??? -20°?? ?? 2?? ?? ??? ? ????.
InChIKey
RYSMHWILUNYBFW-GRIPGOBMSA-N
EPA
Adenosine, 3'-amino-3'-deoxy-N,N-dimethyl- (58-60-6)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi,Xn
?? ???? ?? 48/22
WGK ?? 3
RTECS ?? AU7337000
F ?????? 10-21
TSCA Yes
HS ?? 29419090
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H373 ??? ?? ?? ???? ??(??, ??? ?? ??? ?? ??? ??)? ??? ??? ? ?? ?? ???? ?? - ?? ?? ?? 2 ?? P260, P314, P501
??????:
P260 ??·?·??·???·??·...·????? ???? ???.
P314 ???? ??? ???? ??·??? ????.

PUROMYCIN AMINONUCLEOSIDE C??? ??, ??, ??

??? ??

White crystal

??

Puromycin aminonucleoside is a semi-synthetic derivative of puromycin which lacks the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis, but exhibits antitumour properties. Puromycin aminonucleoside-induced nephrosis is a well-described model of human idiopathic nephrotic syndrome, suppressing integrin expression in cultured glomerular epithelial cells.

??

ChEBI: Puromycin derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring.

Safety Profile

An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx,.

PUROMYCIN AMINONUCLEOSIDE ?? ?? ? ???

???

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PUROMYCIN AMINONUCLEOSIDE ?? ??

???( 170)?? ??
??? ?? ??? ?? ?? ? ??
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PUROMYCIN AMINONUCLEOSIDE ?? ??:

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