??? ?
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??? ? ??
- ???
- 64.43 °C
- ?? ??
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- ???
- ?? ???? ??? ?? ??? ???? ?????? ?? ???? ????.
- ??? ??
- ??
- ??? ??
- ??? ??
- ??
- ????? ?? ???
- ??
- ??? ??? ??, ? ??
- ???? ??
- Xanthomonas campestris
- Merck
- 14,10057
- ???
- ????. ?? ??. ?? ???? ???? ????.
- InChI
- InChI=1S/C8H12N2O2.2ClH/c9-6-1-2-8(7(10)5-6)12-4-3-11;;/h1-2,5,11H,3-4,9-10H2;2*1H
- InChIKey
- VXYWXJXCQSDNHX-UHFFFAOYSA-N
- SMILES
- C(O)COC1=CC=C(N)C=C1N.[H]Cl.[H]Cl
- LogP
- 3.926 (est)
- CAS ??????
- 11138-66-2(CAS DataBase Reference)
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ????? | 24/25 | ||
|---|---|---|---|
| WGK ?? | 1 | ||
| HS ?? | 32139000 | ||
| ???? ?? | KE-35422 |
| ????(GHS): |
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| ?? ?: | Warning | |||||||||||||||||||||
| ??·?? ??: |
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| ??????: |
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??? ? C??? ??, ??, ??
??
??? ?? ?? ?????. Xanthan gum E415? ???? Xanthomonas campestris? ??? ?? ?? ??? ?? ???, ?? ?? ??? ?? ??? ?? ???? ?? ? ????. ?? D- ???, D- ????, D- ?? ? ?? ? ???? ?????. ? ?? ?? ?? ?? ??? ?? ????? ?? ???? ???? ????.??
?? ? E415? ???? ???? (1 ~ 2 ??). ??? ?? ???? ??? ???? ?? ???? ?? ?? ??? ??? ???? ? ???? ?????. ??? ??? ? ??? ? ?? ?? ???? ??? ??? ???? ?? ??? ? ??? ??? ??????.??
?? ? E415 ?? ???? ?? ???? ????? ???, ???, ? ???, ??? ? ? ?? ?? ?? ??? ??? ? ????.????
? (1) ?? : ? ??? ?????? ?? ??? ?, ? ?? 4.0ppm ????? ??.
??(2) ? : ? ?? 5.0g? ??? ??????? ?? ?????????????? ?? ??? ?, ? ?? 2.0ppm ????? ??.
??(3) ??????? : ? ?? 4g? ??? ?? 300mL ??????? ??, ? 200mL? ?? ??, ??? ? ????? 1mL? ?? ? ????. ?? ????? ??? ?? 100mL??? ???? ??? ?????? 4mL? ??? ??? ?? ?? ??? ??? ??? ????? 1?? 2～3mL? ?? ??? ??? ? 90mL? ? ??? ??? ?? ?? ??? 100mL? ? ?? ?????? ??. ??, ??????? tert-????(1→1,000)? ????. ??, ??????? 0.5g? ??? ?? ?? ??? 500mL? ??, ?? ?? 2mL ? ?????? 4mL? ?? ?? ?? ??? 100mL? ? ?? ?????? ??. ???? ? ????? ?? 2μL? ??? ??? ?????? ?????????? ????. ??? ???? ? ???? ?? tert-????????? ?? ???????? ????? QT ? QS? ?? ??? ?? ???? ?? ???????? ?? ?? ?, ? ?? 0.05% ????? ??.
????
?????????? ? : PLOT Q ?? ?? ??? ?
?????? ?? ? : ?????????(FID)
????????? : 200℃
??? ???? : 120℃
????????? : 300℃
????????? : ?? ?? ??
??(4) ?? : ? ??? 1% ???? ????? ? ?2? ??? ?????? ?? ??? ?, 600cps ????? ??.
??(5) ?? : ? ??? ?????? ?? ??? ?, ? ?? 1.5% ????? ??.
??(6) ??? : ? ??? 「??? ?? ? ??」 ?????? ?????? ? ???(?????)? ?? ??? ?, ?? 1g ? 5,000 ????? ??.
??(7) ??? : ? ??? 「??? ?? ? ??」 ?????? ?????? ? ???? ?? ??? ?, ??(-)??? ??.
??(8) ???? : ? ??? 「??? ?? ? ??」 ?????? ?????? ? ????? ?? ??? ?, ??(-)??? ??.
??(9) ??? : ? ??? 「??? ?? ? ??」 ?????? ?????? ? ???? ?? ??? ?, ?? 1g ? 500 ????? ??.
????
? 500mL ???? 80℃? ??? ? 300mL? ?? ????? ? ?? 1.5g ? ?????? 1.5g? ??? ??? ? 30?? 60℃??? ???? ??? ?? 2?? ?? ???? ??? ?, ??? ?? ????. ??????? ?? ?? ???? ??? ?? ???? ???.
??
? ? ??? Xanthomonas campestris?? ???? ????? ???? ????? ?? ?????????? ???????? ???? ????, ??? ???? ? ??? ???, ??? ? ?????? ???, ?? ? ??? ??? ??? ?????.
?????
? ? ??? ??? ?? ? 3g? ??? ??? ????????? ?? ??? ?, ? ?? 6.5～16.0%??? ??.
??? ??
Xanthan gum occurs as a cream- or white-colored, odorless, freeflowing, fine powder.??
xanthan gum (corn starch gum) serves as a texturizer, carrier agent, and gelling agent in cosmetic preparations. It also stabilizes and thickens formulations. This gum is produced through a fermentation of carbohydrate and Xanthomonas campestris.?? ??
Xanthan gum is a polysaccharide produced by a pure-culture aerobic fermentation of a carbohydrate with Xanthomonas campestris. The polysaccharide is then purified by recovery with propan-2-ol, dried, and milled.?? ??
As xanthan is a polysaccharide used in many applications such as a food additive, enzyme substrate or rheology modifier, it is useful to have a xanthan standard with a clearly defined narrow molecular weight distribution. Xanthan is produced by fermentation from Xanthomonas campestris.Safety Profile
When heated to decomposition it emits acrid smoke and irritating fumes.Safety
Xanthan gum is widely used in oral and topical pharmaceutical formulations, cosmetics, and food products, and is generally regarded as nontoxic and nonirritant at the levels employed as a pharmaceutical excipient.The estimated acceptable daily intake for xanthan gum has been set by the WHO at up to 10 mg/kg body-weight.
No eye or skin irritation has been observed in rabbits and no skin allergy has been observed in guinea pigs following skin exposure. No adverse effects were observed in long term feeding studies with rats (up to 1000 mg/kg/day) and dogs (up to 1000 mg/kg/day). No adverse effects were observed in a three-generation reproduction study with rats (up to 500 mg/kg/day).
LD50 (dog, oral): >20 g/kg
LD50 (rat, oral): >45 g/kg
LD50 (mouse, oral): >1 g/kg
LD50 (mouse, IP): >50 mg/kg
LD50 (mouse, IV): 100–250 mg/kg
??
Xanthan gum is a stable material. Aqueous solutions are stable over a wide pH range (pH 3–12), although they demonstrate maximum stability at pH 4–10 and temperatures of 10–60°C. Xanthan gum solutions of less than 1% w/v concentration may be adversely affected by higher than ambient temperatures: for example, viscosity is reduced. Xanthan gum provides the same thickening, stabilizing, and suspending properties during long-term storage at elevated temperatures as it does at ambient conditions. In addition, it ensures excellent freeze–thaw stability. Solutions are also stable in the presence of enzymes, salts, acids, and bases. Vanzan NF-ST is especially designed for use in systems containing high salt concentrations as it dissolves directly in salt solutions, and its viscosity is relatively unaffected by high salt levels as compared with general purpose grades.The bulk material should be stored in a well-closed container in a cool, dry place.
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral solutions, suspensions, and tablets; rectal and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.??? ? ?? ?? ? ???
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