ChemicalBook >?? ???? >5,12-?????????[2,3-b]????

5,12-?????????[2,3-b]????

5,12-?????????[2,3-b]???? ??? ???

?? ??:: 531-46-4

???:: 5,12-?????????[2,3-b]????

???(??):: 5,12-?????????[2,3-b]????

???:: 5,12-dihydroquinoxalino[2,3-b]quinoxaline

???(??):: ML-090;Fluoflavine;5,12-dihydroquinoxalino[2,3-b]quinoxaline;6,11-dihydroquinoxalino[2,3-b]quinoxaline;Quinoxalino[2,3-b]quinoxaline, 5,11-dihydro-;5,12-Dihydroquinoxalino[2,3-b]quinoxaline (~90%);NOX4,ML090,NADPH Oxidase,Inhibitor,NOX,HEK293 cell,NOX3,ML 090,NOX2,inhibit,ML-090,NOX1

CBNumber:: CB31549066

???:: C14H10N4

??? ??:: 234.26

MOL ??:: 531-46-4.mol

?? ?? 19

5,12-?????????[2,3-b]???? ??

???: >262°C (dec.)

?? ?: 450.2±28.0 °C(Predicted)

??: 1.43±0.1 g/cm3(Predicted)

?? ??: -20°C Freezer

???: DMSO(?? ??, ??? ??)? ???

??? ??: ??

??? ??: ??? ??

?? ?? (pKa): 3.94±0.20(Predicted)

??: ???? ?? ?????

InChI: InChI=1S/C14H10N4/c1-2-6-10-9(5-1)15-13-14(16-10)18-12-8-4-3-7-11(12)17-13/h1-8H,(H,15,17)(H,16,18)

InChIKey: WGKYYZDYHYOKQV-UHFFFAOYSA-N

SMILES: N1C2=C(C=CC=C2)N=C2NC3=C(N=C12)C=CC=C3

??

5,12-?????????[2,3-b]???? C??? ??, ??, ??

??

NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer. ML-090 is the first identified NOX1-specific inhibitor (IC₅₀ = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC₅₀s ≥ 10 μM) and xanthine oxidase (IC₅₀ = 3.5 μM).

??

5,12-Dihydroquinoxalino[2,3-b]quinoxaline is an inhibitor of?NADPH oxidase 1 (NOX1).

5,12-?????????[2,3-b]???? ?? ?? ? ???

???

?? ??

5,12-?????????[2,3-b]???? ?? ??

???( 19)?? ??

???	??	???	??	?? ?	??
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32077	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52925	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Zhengzhou Huiju Chemical Co., Ltd.	0371-55900031 18137872243	2853979815@qq.com	China	10004	55
Shanghai TenSus Biotechnology Co., Ltd.	021-50895067 18616507272	tensus@163.com	China	4207	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11217	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8140	58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd	0431-80514535 19917294565	caoy@chemextension.com	China	4754	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	62163	58

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天