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5,12-dihydroquinoxalino[2,3-b]quinoxaline

5,12-dihydroquinoxalino[2,3-b]quinoxaline Struktur
531-46-4
CAS-Nr.
531-46-4
Englisch Name:
5,12-dihydroquinoxalino[2,3-b]quinoxaline
Synonyma:
ML-090;Fluoflavine;5,12-dihydroquinoxalino[2,3-b]quinoxaline;6,11-dihydroquinoxalino[2,3-b]quinoxaline;Quinoxalino[2,3-b]quinoxaline, 5,11-dihydro-;5,12-Dihydroquinoxalino[2,3-b]quinoxaline (~90%);NOX4,ML090,NADPH Oxidase,Inhibitor,NOX,HEK293 cell,NOX3,ML 090,NOX2,inhibit,ML-090,NOX1
CBNumber:
CB31549066
Summenformel:
C14H10N4
Molgewicht:
234.26
MOL-Datei:
531-46-4.mol

5,12-dihydroquinoxalino[2,3-b]quinoxaline Eigenschaften

Schmelzpunkt:
>262°C (dec.)
Siedepunkt:
450.2±28.0 °C(Predicted)
Dichte
1.43±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
L?slichkeit
DMSO (Slightly, Heated, Sonicated)
Aggregatzustand
Solid
pka
3.94±0.20(Predicted)
Farbe
Off-White to Dark Yellow
InChI
InChI=1S/C14H10N4/c1-2-6-10-9(5-1)15-13-14(16-10)18-12-8-4-3-7-11(12)17-13/h1-8H,(H,15,17)(H,16,18)
InChIKey
WGKYYZDYHYOKQV-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC=C2)N=C2NC3=C(N=C12)C=CC=C3

Sicherheit

5,12-dihydroquinoxalino[2,3-b]quinoxaline Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer. ML-090 is the first identified NOX1-specific inhibitor (IC50 = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC50s ≥ 10 μM) and xanthine oxidase (IC50 = 3.5 μM).

Verwenden

5,12-Dihydroquinoxalino[2,3-b]quinoxaline is an inhibitor of?NADPH oxidase 1 (NOX1).

5,12-dihydroquinoxalino[2,3-b]quinoxaline Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

5,12-dihydroquinoxalino[2,3-b]quinoxaline Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 19)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
+86-18341751992 +86-15382112998
 757984502@qq.com China 892 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
Zhengzhou Huiju Chemical Co., Ltd. 0371-55900031 18137872243
 2853979815@qq.com China 10001 55
Shanghai TenSus Biotechnology Co., Ltd. 021-50895067 18616507272
 tensus@163.com China 4207 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11218 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
 order@med-bio.cn China 8140 58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd 0431-80514535 19917294565
 caoy@chemextension.com China 4753 58
Bide Pharmatech Ltd. 400-1647117 13681763483
 product02@bidepharm.com China 62075 58
  • 5,12-dihydroquinoxalino[2,3-b]quinoxaline
  • Fluoflavine
  • ML-090
  • Quinoxalino[2,3-b]quinoxaline, 5,11-dihydro-
  • 5,12-Dihydroquinoxalino[2,3-b]quinoxaline (~90%)
  • 6,11-dihydroquinoxalino[2,3-b]quinoxaline
  • NOX4,ML090,NADPH Oxidase,Inhibitor,NOX,HEK293 cell,NOX3,ML 090,NOX2,inhibit,ML-090,NOX1
  • 531-46-4
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