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?????? ??
- ???
- 139°
- ?? ?
- 580.3±40.0 °C(Predicted)
- ??
- 1.224±0.06 g/cm3(Predicted)
- ?? ??
- 2-8°C(protect from light)
- ?? ?? (pKa)
- 7.09±0.40(Predicted)
- CAS ??????
- 59338-93-1(CAS DataBase Reference)
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- ?? ? ???? ?? (GHS)
| ?? | LD50 i.v. in mice (5 days): 92.7 mg/kg (Bulteau) |
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Originator
Plitican ,Delagrange ,France ,1981Manufacturing Process
38.6 g (0.2 mol) of 2-methoxy-4,5-azimidobenzoic acid were dissolved in anhydrous toluene and 56 g (0.4 mol) of 1-allyl-2-amino-methylpyrrolidine were added. The mixture was heated to 50°C and then 42 g (0.3 mol) of phosphoric anhydride were added. The mixture was warmed at reflux temperature for 3 hours and then cooled to 80°C. After adding water, the aqueous layer was alkalized. The crystals were filtered, washed with water and then dissolved in 450 ml of acetone. After crystallization, the product was 40.4 g (yield 65%) of N-(1'-allyl-2'-pyrrolidylmethyl)-2-methoxy-4,5- azimidobenzamide having a melting point of 139°C were obtained.Therapeutic Function
Neuroleptic, Antiemetic?????? ?? ?? ? ???
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2-aminomethyl-N-allylpyrrolidine
2-(?????)-1-N-Boc-????
Alizapride hydrochloride
??4-???-2-????????
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Anhydrous toluene
1H-???????-6-????
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1-??-2-?????????
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