Fudosteine
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Fudosteine ??
- ???
- 200-202°C (dec.)
- ?? ?
- 354.5±42.0 °C(Predicted)
- ??
- 1.301±0.06 g/cm3(Predicted)
- ?? ??
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- ???
- ?(?? ???)
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- ?? ?? (pKa)
- 2.09±0.10(Predicted)
- ??
- ???? ?? ????
- CAS ??????
- 13189-98-5(CAS DataBase Reference)
Fudosteine C??? ??, ??, ??
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Fudosteine is a cysteine derivative that interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion, in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-α, or oxidants. Fudosteine, which is a thiol compound with antioxidant properties, limits NF-κB signaling and reduces inflammatory gene expression. It has greater bioavailability than N-acetyl-cysteine and increases cysteine levels in cells.??? ??
Off-White Powder??
Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor. MUC5AC mucin synthesis and the expression of the MUC5AC gene were increased by LPS in rats or TNF-α in NCI-H292 cells; these effects were inhibited by fudosteine treatment???
A reproductive hazard.Fudosteine ?? ?? ? ???
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Fudosteine ?? ??
???( 324)?? ??
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Fudosteine ?? ??:
???(???????)????? ???? 3,3`-?????????? ??-??? ??? 6-??? ???? ???????? ????? ??? ?????
ALTRENOGEST
S-Carboxymethyl-L-cysteine
Erdosteine
L-ALANINE, 3-[(3-HYDROXYPROPYL)SULFINYL]-
Fudosteine Impurity 5
Fudosteine Impurity 2
Fudosteine Impurity 1
Fudosteine Impurity 3
Fudosteine Impurity 2
Fudosteine Impurity 4