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GNE-781

GNE-781 ??? ???
?? ??:
1936422-33-1
???:
GNE-781
???(??):
GNE-781;GNE-781,Histone Acetyltransferase,Inhibitor,HATs,Epigenetic Reader Domain,GNE 781,HAT,inhibit,GNE781;3- (7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3.4-dihydro-2H-quinohn-1-yl]-N-methyl-1-(oxan-4-yl)-6,7-dihydro-4H-pyrazolo[4.3-c]pyridine-5-carboxamide;3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide;5H-Pyrazolo[4,3-c]pyridine-5-carboxamide, 3-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-1,4,6,7-tetrahydro-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-
CBNumber:
CB04667955
???:
C27H33F2N7O2
??? ??:
525.59
MOL ??:
1936422-33-1.mol

GNE-781 ??

???
135-140oC
?? ?
800.7±65.0 °C(Predicted)
??
1.45±0.1 g/cm3(Predicted)
?? ??
Refrigerator
???
DMSO(?? ???), ???(?? ???)
?? ?? (pKa)
14.19±0.20(Predicted)
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GNE-781 C??? ??, ??, ??

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GNE-781 is a highly advanced, potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein, binding protein (CBP). Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology.

GNE-781 ?? ?? ? ???

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GNE-781 ?? ??

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