?????
????? ??? ???
?? ??:
154229-19-3
???:
?????
???(??):
?????
???:
Abiraterone
???(??):
Cb-7598;7-Keto Abiraterone Acetate;(3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol;Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, (3beta)-;(3S,8R,9S,10R,13S,14S)-10,13-diMethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol;CS-211;Abiron;Cb 7598;Abytron;Abitelon
CBNumber:
CB01320705
???:
C24H31NO
??? ??:
349.52
MOL ??:
154229-19-3.mol
????? ??
???
227-228 °C(Solv: toluene (108-88-3))
?? ?
500.2±50.0 °C(Predicted)
??
1.14±0.1 g/cm3(Predicted)
?? ??
2-8°C
???
?????(?? ???), ???(?? ???)
??? ??
??
??? ??
??? ??
?? ?? (pKa)
14.71±0.70(Predicted)
??
???? ?? ???
CAS ??????
154229-19-3
??
?? ? ?? ??
?? ? ???? ?? (GHS)
????(GHS):
?? ?:
Warning
??·?? ??:
??
??·?? ??
?? ??
??
?? ?
?? ??
P- ??
H302 ??? ???
?? ?? ?? - ??
?? 4
??
P264, P270, P301+P312, P330, P501
H315 ??? ??? ???
????? ?? ?????
?? 2
??
P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ???
?? ? ?? ?? ??? ??
?? 2A
??
P264, P280, P305+P351+P338,P337+P313P
H332 ???? ???
?? ?? ?? ??
?? 4
??
P261, P271, P304+P340, P312
H335 ?? ???? ??? ? ??
?? ???? ?? - 1? ??;???? ??
?? 3
??
??????:
P233 ??? ??? ?????.
??? ??? ? ?? ?? ??? ???? ?????.
P260 ??·?·??·???·??·...·????? ???? ???.
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P304 ???? ???? ??? ????(??)? ??? ????
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P312 ???? ??? ????(??)? ??? ????.
P321 (…) ??? ???.
P330 ?? ?????.
P332+P313 ?? ??? ??? ???? ??· ??? ????.
P337+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P340 ??? ??, ??, ???? ?? ??? ???
P362 ??? ??? ?? ?? ?? ?????
P403 ??? ? ?? ?? ?????.
P403+P233 ??? ??? ? ?? ?? ??? ???? ?????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.
????? C??? ??, ??, ??
??? ??
White Solid
??
Abiraterone, a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent pr
ostate cancer.
??
ChEBI: A 3beta-sterol that is androsta-5,16-dien-3beta-ol substituted at position 17 by a 3-pyridyl group. Administered as the O-acetate, it is used for treatment of metastatic castrate-resistant prostate cance
.
????? ?? ?? ? ???
???
?? ??
????? ?? ??
???( 451)?? ??
Australia 1
Belgium 1
Canada 4
China 362
Czech Republic 1
Europe 2
Greece 1
India 27
Japan 2
Poland 1
Spain 1
The Netherlands 1
United Kingdom 4
United States 43
Global 451
