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TRICHOSTATIN A

TRICHOSTATIN A ??? ???
?? ??:
58880-19-6
???:
TRICHOSTATIN A
???(??):
TSA;A 300I;CS-210;CS-2704;trichostatin;richostatinA;TRICHOSTATIN A;(R)-Trichostatin A;(+)-Trichostatin A;Trichostatin A (TSA)
CBNumber:
CB8257301
???:
C17H22N2O3
??? ??:
302.37
MOL ??:
58880-19-6.mol
MSDS ??:
SDS

TRICHOSTATIN A ??

???
140-143℃
??
D20.5 +62.8° ±1.1° (c = 1.007 in ethanol)
??
1.139
???
136 ° (C=0.3, MeOH)
?? ??
-20°C
???
???: 1mg/mL
?? ?? (pKa)
8.93±0.23(Predicted)
??? ??
???? ????? ??
??
??? ? ???
Merck
14,9649
???
??? ?? ?????? 2? ?? ??????. DMSO ?? ??? ??? -20°?? ?? 3?? ?? ??? ? ????.
InChIKey
ZWGICMNKJBUOHG-RCXLNATQSA-N
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn,Xi
?? ???? ?? 20/21/22-36/37/38-43
????? 26-36
????(UN No.) NA 1993 / PGIII
WGK ?? 3
RTECS ?? MI5215000
HS ?? 29280000
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 ????? ?? ??? ??? ? ?? ?? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P280 ????/???/???/?????? ?????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
0
3 0

TRICHOSTATIN A C??? ??, ??, ??

??? ??

Solid

??

Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells.

?? ??

Trichostatin A is a compound of primary hydroxamic acid.

???? ??

Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.

TRICHOSTATIN A ?? ?? ? ???

???

?? ??

TRICHOSTATIN A ?? ??

???( 229)?? ??
??? ?? ??? ?? ?? ? ??
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TRICHOSTATIN A ?? ??:

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