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ロピバカイン

ロピバカイン 化學(xué)構(gòu)造式
84057-95-4
CAS番號(hào).
84057-95-4
化學(xué)名:
ロピバカイン
別名:
S-ロピバカイン;(2S)-1-プロピル-2-(2,6-ジメチルフェニル)カルバモイルピペリジン;ロピバカイン;(2S)-1-プロピル-N-(2,6-ジメチルフェニル)ピペリジン-2-カルボアミド;(S)-ロピバカイン;(2S)-N-(2,6-ジメチルフェニル)-1-プロピルピペリジン-2-カルボキサミド
英語(yǔ)名:
Ropivacaine
英語(yǔ)別名:
Naropin;ROPIVACAINE MESYLATER;RopivacaineHcl/MesylateBase;(S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide;Seduron;Naropine;ROPIVACAINE;MesylateBase;S-ROPIVACAINE;ROPACARAINEHCL
CBNumber:
CB4412687
化學(xué)式:
C17H26N2O
分子量:
274.4
MOL File:
84057-95-4.mol

ロピバカイン 物理性質(zhì)

融點(diǎn) :
144-146°
比旋光度 :
D25 -82.0° (c = 2 in methanol)
沸點(diǎn) :
410.2±45.0 °C(Predicted)
比重(密度) :
1.044±0.06 g/cm3(Predicted)
貯蔵溫度 :
Refrigerator
溶解性:
水酸 (微量)、クロロホルム (微量)、DMSO (微量)、メタノール (微量)
外見 :
個(gè)體
酸解離定數(shù)(Pka):
8.16(at 25℃)
色:
ホワイトからオフホワイト
InChIKey:
ZKMNUMMKYBVTFN-HNNXBMFYSA-N
CAS データベース:
84057-95-4(CAS DataBase Reference)
安全性情報(bào)
  • リスクと安全性に関する聲明
  • 危険有害性情報(bào)のコード(GHS)
HSコード  2933399090
絵表示(GHS) GHS hazard pictogramsGHS hazard pictograms
注意喚起語(yǔ) 危険
危険有害性情報(bào)
コード 危険有害性情報(bào) 危険有害性クラス 區(qū)分 注意喚起語(yǔ) シンボル P コード
H336 眠気やめまいのおそれ 特定標(biāo)的臓器毒性、単回暴露; 麻酔作用 3 警告 P261, P271, P304+P340, P312,P403+P233, P405, P501
H370 臓器の障害 特定標(biāo)的臓器有害性、単回暴露 1 危険 GHS hazard pictograms P260, P264, P270, P307+P311, P321,P405, P501
注意書き
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時(shí)に、飲食または喫煙をしないこ と。
P271 屋外または換気の良い場(chǎng)所でのみ使用すること。

ロピバカイン 価格 もっと(2)

メーカー 製品番號(hào) 製品説明 CAS番號(hào) 包裝 価格 更新時(shí)間 購(gòu)入
Sigma-Aldrich Japan PHR2571 ロピバカイン
Ropivacaine
84057-95-4 500MG ¥37300 2024-03-01 購(gòu)入
Sigma-Aldrich Japan 1605497 ロピバカイン United States Pharmacopeia (USP) Reference Standard
Ropivacaine United States Pharmacopeia (USP) Reference Standard
84057-95-4 200mg ¥58400 2024-03-01 購(gòu)入

ロピバカイン MSDS


Ropivacaine

ロピバカイン 化學(xué)特性,用途語(yǔ),生産方法

効能

局所麻酔薬

説明

Ropivacaine is an aminoamide local anaesthetic drug commonly marketed by AstraZeneca under the trade name Naropin. Naropin was launched in 1996 in Australia, Denmark, Finland, the Netherlands and Sweden as a local anesthetic. It can be prepared in a number of ways the most efficient involves a three step sequence beginning with L-pipecolic acid. This compound is the first one in this family to be produced as the pure (S)- enantiomer. The (R)-enantiomer has been shown to have cardiotoxic effects. Thus ropivicaine has less cardiovascular and CNS toxicity than bupivacaine. It is a Na channel blocker that is specific for affecting nerve fibers responsible for transmission of pain (Aδ and C) with no effect on fibers responsible for motor function (Aβ). Clinically, it has distinct advantages over bupivacaine. Its effects are slower in onset, less intense and have a shorter duration. This is a result of extensive metabolism in the liver to the 3-hydroxy isomer by CYPIA2 isoenzyme.
Ropivacaine is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to your brain.
Ropivacaine is used as a local (in only one area) anesthesia for a spinal block, also called an epidural. The medication is used to provide anesthesia during a surgery or C-section, or to ease labor pains.
https://www.drugs.com/mtm/ropivacaine.html

使用

Ropivacaine is a pure S(-)-enantiomer of propivacaine. It is a long-acting amide local anesthetic that has efficacy and potency nearly as high as bupivacaine and levobupivacaine but has lower CNS and cvS toxicity. If there are any differences between bupivacaine and ropivacaine it is the slightly shorter period of activity in spinal and epidural applications and a lowered ability to penetrate large motor nerves. It is the reduced lipophilicity that contributed to the lowered penetration of the motor nerves, combined with its stereoselective properties that allows ropivacaine to have significantly reduced Cvs toxicity compared to bupivacaine (Simpson et al. 2005). Ropivacaine has a diphasic effect on peripheral vasculature-it is vasoconstrictive when injected at a concentration below 0.5 w/v% and there is dilation at concentrations over 1 w/v% (Cederholm et al. 1992).
Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.
http://www.selleckchem.com/products/ropivacaine-hcl.html

定義

ChEBI: A piperidinecarboxamide-based amide-type local anaesthetic (amide caine) in which (S)-N-propylpipecolic acid and 2,6-dimethylaniline are combined to form the amide bond.

生物學(xué)の機(jī)能

Ropivacaine (Naropin) is a recently developed longacting amide-linked local anesthetic. Its duration of action is similar to that of bupivacaine, but it is slightly less potent and requires higher concentrations to achieve the same degree of block. Its primary advantage over bupivacaine is its lesser degree of cardiotoxicity.

一般的な説明

The recognized increase in cardiotoxicity of one bupivacaineisomer led to the stereospecific production of ropivacaine asthe single “S” (-) enantiomer. Ropivacaine is the propylanalog of mepivacaine (methyl) and bupivacaine (butyl). ThepKa of the tertiary nitrogen is 8.1, and it displays the same degreeof protein binding as bupivacaine ( 94%). Althoughropivacaine has similar properties as bupivacaine, it displaysless cardiotoxicity. The shortened alkyl chain gives it approximatelyone third of the lipid solubility of bupivacaine.

作用機(jī)序

Ropivacaine is a member of the amino amide class of local anesthetics and is supplied as the pure S-(- )-enantiomer. Local anesthetics block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: (1) pain, (2) temperature, (3) touch, (4) proprioception, and (5) skeletal muscle tone.

薬理學(xué)

This is a single (S–) enantiomer, similar in structure to bupivacaine. S ubstitution of a propyl for the butyl side chain of bupivacaine reduces lipid solubility; this leads to reduced potential for toxicity and also greater separation between sensory and motor blockade. Efficacy is similar, but motor block is reduced compared with equianalgesic doses of racemic bupivacaine.

臨床応用

Ropivacaine is a long-acting amide-type local anestheticwith inherent vasoconstrictor activities, so it does not requirethe use of additional vasoconstrictors. It is approved forepidural, nerve block, infiltration, and intrathecal anesthesia.

副作用

Reactions to ropivacaine are characteristic of those associated with other amide-type local anesthetics. A major cause of adverse reactions to this group of drugs may be associated with excessive plasma levels, which may be due to overdosage, unintentional intravascular injection or slow metabolic degradation.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
Blurred vision
chest pain or discomfort
confusion
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
lightheadedness, dizziness, or fainting
slow or irregular heartbeat
sweating
unusual tiredness or weakness
Less common
Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chills
decrease in frequency or amount of urine
difficulty in passing urine (dribbling)
fever
painful urination
Rare
Absence of or decrease in body movement
agitation
anxiety
https://www.mayoclinic.org/drugs-supplements/ropivacaine-injection-route/side-effects/drg-20065875
https://www.accessdata.fda.gov/

代謝

The metabolism of ropivacaine in human is mediated by hepatic CYP1A2 isozymes and, to a minor extent, by CYP3A4. The major metabolite is 3-hydroxyropivacaine, and the minor metabolite is (S)-2′,6′-pipecoloxylidide (a N-dealkylated product).
Ropivacaine is extensively metabolized in the liver, predominantly by aromatic hydroxylation mediated by cytochrome P4501A to 3-hydroxyropivacaine. After a single IV dose approximately 37% of the total dose is excreted in the urine as both free and conjugated 3-hydroxy ropivacaine. Low concentrations of 3-hydroxy ropivacaine have been found in the plasma. Urinary excretion of the 4-hydroxy ropivacaine, and both the 3-hydroxy N-de-alkylated (3-OH-PPX) and 4-hydroxy N-dealkylated (4-OH-PPX) metabolites account for less than 3% of the dose. An additional metabolite, 2- hydroxy-methyl-ropivacaine, has been identified but not quantified in the urine. The N-de-alkylated metabolite of ropivacaine (PPX) and 3-OH-ropivacaine are the major metabolites excreted in the urine during epidural infusion. Total PPX concentration in the plasma was about half as that of total ropivacaine; however, mean unbound concentrations of PPX were about 7 to 9 times higher than that of unbound ropivacaine following continuous epidural infusion up to 72 hours. Unbound PPX, 3- hydroxy and 4-hydroxy ropivacaine, have a pharmacological activity in animal models less than that of ropivacaine. There is no evidence of in vivo racemization in urine of ropivacaine.
https://www.accessdata.fda.gov

ロピバカイン 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品


ロピバカイン 生産企業(yè)

Global( 230)Suppliers
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ロピバカイン  スペクトルデータ(1HNMR)


84057-95-4(ロピバカイン)キーワード:


  • 84057-95-4
  • ROPACARAINEHCL
  • (S)-N-(2,6-Dimethylphenyl)-1-pKIpyl-2-piperidinecarboxamide
  • 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, (2S)-
  • Naropine
  • (2S)-1-Propyl-2-(2,6-dimethylphenyl)carbamoylpiperidine
  • (2S)-1-Propyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
  • Ropivacainebase
  • Ropivacaine (200 mg)
  • Ropivacaine API
  • Ropivacaine HCl (base)
  • (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide
  • (2S)-N-(2,6-dimethylphenyl)-1-propyl-piperidine-2-carboxamide
  • Ropivacaine Free base
  • (2r,2'r,3r,3'r,4r)-2,2'-bis(3,4-dihydroxyphenyl)-5,5',7,7'-tetrahydroxy-3,3',4,4'-tetrahydro-2h,2'h-4,8'-bichromene-3,3'-diyl bis(3,4,5-trihydroxybenzoate)
  • S-ROPIVACAINE
  • ROPIVACAINE
  • n-(2,6-dimethylphenyl)-1-propyl-piperidine-2-carboxamide
  • Ropivacaine HCl 84057-95-4
  • ROPIVACAINE CAS NO:84057-95-4
  • MesylateBase
  • ROM. Pp because
  • Ropivacaine USP/EP/BP
  • RopivacaineQ: What is Ropivacaine Q: What is the CAS Number of Ropivacaine Q: What is the storage condition of Ropivacaine Q: What are the applications of Ropivacaine
  • Ropivacaine (1605497)
  • Ropivacaine Base With
  • Seduron
  • ROPIVACAINE MESYLATER
  • RopivacaineHcl/MesylateBase
  • Naropin
  • (S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide
  • S-ロピバカイン
  • (2S)-1-プロピル-2-(2,6-ジメチルフェニル)カルバモイルピペリジン
  • ロピバカイン
  • (2S)-1-プロピル-N-(2,6-ジメチルフェニル)ピペリジン-2-カルボアミド
  • (S)-ロピバカイン
  • (2S)-N-(2,6-ジメチルフェニル)-1-プロピルピペリジン-2-カルボキサミド
  • 局所麻酔薬
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