くえん酸ピペラジン水和物 化學(xué)特性,用途語(yǔ),生産方法
外観
白色～淡黃色の結(jié)晶又は結(jié)晶性粉末
用途
有機(jī)合成原料。
説明
Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism.
化學(xué)的特性
Piperazine citrate is a white, crystalline powder, with not more than a slight odor. It is soluble in water, and insoluble in alcohol and in ether.
使用
Piperazine Citrate is an anthelmintic agent used in the treatment of parasitic infections. Also used in the reduction of blood pressure.
適応癥
Used as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.
作用機(jī)序
Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.
薬物動(dòng)態(tài)學(xué)
Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.
くえん酸ピペラジン水和物 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品