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ChemicalBook >> CAS DataBase List >>Nicardipine

Nicardipine

CAS No.
55985-32-5
Chemical Name:
Nicardipine
Synonyms
NICARDIPINE;NicardipineBase;Nicardipine USP/EP/BP;Nicardipine Hcl 54527-84-3 / Base;benzylmethylamino)ethylmethylester;NICARDIPINE 20% SR, 33% SR PELLETS;Nicardipine (base and/or unspecified salts);2-(benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)pyridine-3,5-dicarboxylate;Methyl 2-(benzyl-methyl-amino)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CBNumber:
CB2487861
Molecular Formula:
C26H29N3O6
Molecular Weight:
479.52
MDL Number:
MFCD00216027
MOL File:
55985-32-5.mol
Last updated:2024-11-18 17:01:59

Nicardipine Properties

Melting point 136-138 °C
Boiling point 603.4±55.0 °C(Predicted)
Density 1.230±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Dichloromethane; Methanol
form Solid
pka 7.30±0.50(Predicted)
color Yellow
CAS DataBase Reference 55985-32-5(CAS DataBase Reference)
FDA UNII CZ5312222S
NCI Drug Dictionary nicardipine
ATC code C08CA04

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501

Nicardipine price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC N394503 Nicardipine 55985-32-5 500mg $485 2021-12-16 Buy
Biorbyt Ltd orb611926 Nicardipine 55985-32-5 25g $598.4 2021-12-16 Buy
American Custom Chemicals Corporation API0009043 NICARDIPINE 95.00% 55985-32-5 50G $3265.94 2021-12-16 Buy
Biosynth Carbosynth BN166182 Nicardipine 55985-32-5 100mg $50 2021-12-16 Buy
American Custom Chemicals Corporation API0009043 NICARDIPINE 95.00% 55985-32-5 100MG $328.65 2021-12-16 Buy
Product number Packaging Price Buy
N394503 500mg $485 Buy
orb611926 25g $598.4 Buy
API0009043 50G $3265.94 Buy
BN166182 100mg $50 Buy
API0009043 100MG $328.65 Buy

Nicardipine Chemical Properties,Uses,Production

Originator

Nicodel,Mitsui,Japan,1981

Uses

It is used for arterial hypertension, chronic, stable angina pectoris, preventing angina pectoris, and for ischemic-type abnormalities of brain blood flow.

Uses

Vasodilator.

Uses

Nicardipine is a dihydropyridine calcium channel blocker. Antianginal; antihypertensive. Neuroprotective & Neuroresearch products.

Definition

ChEBI: Nicardipine is a racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension. It has a role as an antihypertensive agent, a calcium channel blocker, a vasodilator agent and an autophagy inhibitor. It contains a (S)-nicardipine and a (R)-nicardipine.

Manufacturing Process

A mixture of 4.98 g of acetoacetic acid N-benzyl-N-methylaminoethyl ester, 2.3 g of β-aminocrotonic acid methyl ester, and 3 g of m-nitrobenzaldehyde was stirred for 6 hours at 100°C in an oil bath. The reaction mixture was subjected to a silica gel column chromatography (diameter 4 cm and height 25 cm) and then eluted with a 20:1 mixture of chloroform and acetone. The effluent containing the subject product was concentrated and checked by thin layer chromatography. The powdery product thus obtained was dissolved in acetone and after adjusting the solution with an ethanol solution saturated with hydrogen chloride to pH 1-2, the solution was concentrated to provide 2 g of 2,6-dimethyl-4-(3'-nitrophenyl)1,4-dihydropyridine-3,5-dicarboxylic acid 3-methylester-5-β-(N-benzyl-N-methylamino)ethyl ester hydrochloride. The product thus obtained was then crystallized from an acetone mixture, melting point 136°C to 140°C (decomposed).

brand name

Cardene(PDL Biopharma); Cardene (Roche).

Therapeutic Function

Vasodilator

Mechanism of action

Nicardipin relaxes smooth musculature of vessels, lowers resistance of coronary and peripheral vessels, increases blood flow in vessels of the brain, causes a moderate and stable hypotensive effect, and reduces the myocardial need for oxygen.

Synthesis

Nicardipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl-2-[(methylphenylmethyl)- amino]ethyl ester 3,5-pirididincarboxylic acid (19.3.7), is synthesized in a manner analogous to the synthesis of nifedipine, the only difference being that in the Hantsch synthesis, two different |?-dicarbonyl compounds are used simultaneously with o-nitrobenzaldehyde. During this, one of these in the enamine form of acetoacetic ester is simultaneously used as an amine component. A heterocyclization reaction is accomplished by reacting, the methyl ester of |?-aminocrotonic acid with the 2-methyl-2-benzylaminoethyl ester of acetoacetic acid.

Synthesis_55985-32-5

85677-95-8
55985-32-5
Synthesis of Nicardipine from 3-(2-hydroxyethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Global( 138)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32112 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34553 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 7724 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9640 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Sinoway Industrial co., ltd. 		0592-5800732; +8613806035118 xie@china-sinoway.com China 988 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com China 52849 58

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View Lastest Price from Nicardipine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Nicardipine pictures 2024-11-18 Nicardipine
55985-32-5
 US $30.00 / mg 99.56% 10g TargetMol Chemicals Inc.
Nicardipine pictures 2020-05-12 Nicardipine
55985-32-5
 US $0.00-0.00 / KG 1KG 99.0% 500 MT Shaanxi Dideu Medichem Co. Ltd
Nicardipine pictures 2020-01-08 Nicardipine
55985-32-5
 US $0.01 / g 1g 99% 1g,10g,1kg,100kg Career Henan Chemical Co
  • Nicardipine pictures
  • Nicardipine
    55985-32-5
  • US $30.00 / mg
  • 99.56%
  • TargetMol Chemicals Inc.
  • Nicardipine pictures
  • Nicardipine
    55985-32-5
  • US $0.00-0.00 / KG
  • 99.0%
  • Shaanxi Dideu Medichem Co. Ltd
  • Nicardipine pictures
  • Nicardipine
    55985-32-5
  • US $0.01 / g
  • 99%
  • Career Henan Chemical Co

Nicardipine Spectrum

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-[methy(phenyl-methyl)amino]ethyl ester hydrochloride Nicardipine (base and/or unspecified salts) Methyl 2-(benzyl-methyl-amino)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[methyl(benzyl)amino]ethyl]5-methyl ester NicardipineBase Nicardipine Hcl 54527-84-3 / Base 2-(benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)pyridine-3,5-dicarboxylate benzylmethylamino)ethylmethylester 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-[2-[methyl(benzyl)amino]ethyl] ester 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[2-(N-methylbenzylamino)ethyl] ester 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-[2-[benzyl(methyl)amino]ethyl] ester O5-methyl ester 5-O-methyl 3-O-[2-[methyl(phenylmethyl)amino]ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate O5-methyl O3-[2-[methyl(phenylmethyl)amino]ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate NICARDIPINE 5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[2-[methyl(phenylmethyl)amino]ethyl] ester Nicardipine USP/EP/BP NICARDIPINE 20% SR, 33% SR PELLETS 55985-32-5 C26H29N3O6 Active Pharmaceutical Ingredients