AR7
- CAS No.
- 80306-38-3
- Chemical Name:
- AR7
- Synonyms
- AR7;ERBA;ERB-T-1;CS-2649;c-ERBA-1;MGC43240;AR7;AR 7;MGC000261;AR 7(RARα agonist);AR7, 10 mM in DMSO
- CBNumber:
- CB22714659
- Molecular Formula:
- C15H12ClNO
- Molecular Weight:
- 257.71
- MDL Number:
- MFCD27978377
- MOL File:
- 80306-38-3.mol
- MSDS File:
- SDS
| storage temp. | Sealed in dry,2-8°C |
|---|---|
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| color | white to beige |
| biological source | human |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
AR7 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP2127 | TR, α1, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE) | 10μG | $400 | 2024-03-01 | Buy | |
| Sigma-Aldrich | SML0921 | AR7 ≥98% (HPLC) | 80306-38-3 | 5MG | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | SRP2046 | Thyroid Hormone receptor,α1 human recombinant, expressed in insect cells, ≥80% (SDS-PAGE) | 5μG | $471 | 2024-03-01 | Buy | |
| Sigma-Aldrich | SML0921 | AR7 ≥98% (HPLC) | 80306-38-3 | 25MG | $478 | 2024-03-01 | Buy |
| Cayman Chemical | 22946 | AR-7 | 80306-38-3 | 1mg | $32 | 2024-03-01 | Buy |
AR7 Chemical Properties,Uses,Production
Description
AR7 (80306-38-3) is an atypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson’s disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4
Uses
AR 7 is a CMA booster. Used in biological study of chemical modulation of chaperone-?mediated autophagy by retinoic acid derivatives.
References
Anguiano et al. (2013), Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives; Nat. Chem. Biol. 9 374 Ho et al. (2020), Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA); Autophagy 16 347 Bonam et al. (2021), Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease; Cells 10 3547 Hao et al. (2019), Targetome analysis of chaperone-mediated autophagy in cancer cells; Autophagy 15 1558
AR7 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30231 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 |
