| Identification | Back Directory | [Name]
AR7 | [CAS]
80306-38-3 | [Synonyms]
AR7
ERBA
ERB-T-1
CS-2649
MGC43240
AR7;AR 7
c-ERBA-1
MGC000261
AR 7(RARα agonist)
Reaxys ID: 20039175
Atypical retinoid 7
TR, α1, GST tagged human
Thyroid Hormone receptor,α1 human
7-Chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine
7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine
2H-1,4-Benzoxazine, 7-chloro-3-(4-methylphenyl)- | [Molecular Formula]
C15H12ClNO | [MDL Number]
MFCD27978377 | [MOL File]
80306-38-3.mol | [Molecular Weight]
257.71 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [color ]
white to beige | [biological source]
human | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Description]
AR7 (80306-38-3) is an atypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson’s disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4 | [Uses]
AR 7 is a CMA booster. Used in biological study of chemical modulation of chaperone-?mediated autophagy by retinoic acid derivatives. | [storage]
Store at -20°C | [References]
Anguiano et al. (2013), Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives; Nat. Chem. Biol. 9 374
Ho et al. (2020), Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA); Autophagy 16 347
Bonam et al. (2021), Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease; Cells 10 3547
Hao et al. (2019), Targetome analysis of chaperone-mediated autophagy in cancer cells; Autophagy 15 1558 |
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