Edetinsure Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSE KRISTALLE ODER WEI?ES PULVER
PHYSIKALISCHE GEFAHREN
Staubexplosion der pulverisierten oder granulierten Substanz in Gemischen mit Luft m?glich.
CHEMISCHE GEFAHREN
Die Substanz zersetzt sich beim Erhitzen unter Bildung von toxischen Rauchen mit Stickoxiden. Reagiert mit starken Oxidationsmitteln. Greift einige Arten von Metall und Gummi an.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt.
MAK: IIb (nicht festgelegt, aber Informationen vorhanden) (DFG 2008).
AUFNAHMEWEGE
Aufnahme in den K?rper durch Inhalation von D?mpfen oder Aerosolen und durch Verschlucken.
INHALATIONSGEFAHREN
Eine bel?stigende Partikelkonzentration in der Luft kann schnell erreicht werden.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Die Substanz reizt die Augen.
LECKAGE
Pers?nliche Schutzausrüstung: Atemschutzger?t mit Partikelfilter entsprechend der Arbeitsplatzkonzentration des Stoffes. Verschüttetes Material in nichtmetallischen Beh?ltern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgf?ltig sammeln. An sicheren Ort bringen.
R-S?tze Betriebsanweisung:
R36:Reizt die Augen.
R52/53:Sch?dlich für Wasserorganismen, kann in Gew?ssern l?ngerfristig sch?dliche Wirkungen haben.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R36/38:Reizt die Augen und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Aussehen Eigenschaften
C10H16N2O8, Ethylendiamintetraessigsäure
Gefahren für Mensch und Umwelt
Thermische Zersetzung: >250鳦
Struktur-Wirkungs-Überlegungen: Störung des Elektrolythaushaltes möglich. Weitere gefährliche Eigenschaften können nicht ausgeschlossen werden.; LD50 (oral, Ratte): 4500 mg/kg
Abbaubarkeit: BSB
5: 0,01 g/g Biologische Effekte: Fische: L. macrochirus LC
50: 159 mg/l/96 h
Schutzma?nahmen und Verhaltensregeln
Dicht verschlossen und trocken aufbewahren
Staubschutz bei Auftreten von Stäuben
Laborschutzbrille mit Seitenschutz und oberer Augenraumabdeckung
Verhalten im Gefahrfall
Trocken aufnehmen. Der Entsorgung zuführen. Mit Wasser nachreinigen.
Erste Hilfe
Nach Hautkontakt: Mit viel Wasser abwaschen.
Nach Augenkontakt: 15 Minuten bei gespreizten Lidern unter fließendem Wasser mit Augendusche ausspülen. Augenarzt konsultieren!
Nach Verschlucken: Viel Wasser trinken, Erbrechen auslösen. Bei Unwohlsein Arzt hinzuziehen.
Ersthelfer: siehe gesonderten Anschlag
Sachgerechte Entsorgung
Falls Recycling nicht möglich, als Sonderabfall entsorgen, zuständige Stellen: Hubland-Herr Riepl:8884711, Klinikum-Herr Uhl:2015557.
Beschreibung
Ethylenediaminetetraacetic Acid (EDTA) is a common polydentate ligand. In EDTA, the hydrogen atoms are easily removed
in solution to produce anionic EDTA4-. In its anionic form Ethylenediaminetetraacetic Acid (EDTA) has six binding atoms, two
nitrogen and four oxygen.
Ethylenediaminetetraacetic Acid (EDTA) binds to a metal ion at the six binding sites, wrapping itself around the metal ion,
forming a very stable complex.the strong grasp of Ethylenediaminetetraacetic Acid (EDTA) on the metal ion is analogous
to a crab or lobster clamping down on an object with its claw, hence the name chelation.
Ethylenediaminetetraacetic Acid (EDTA) is such an effective chelating agent because it can deactivate a metal at up to six sites.
Chemische Eigenschaften
Ethylenediaminetetraacetic acid is a solid.
History
Ethylenediaminetetraacetic Acid (EDTA) was first synthesized in the early 1930s by the German chemist Ferdinand Münz
working for I. G. Farben. Münz, who was looking for a substitute for citric acid to use with
dye solutions in the textile industry, was the first to patent a process for Ethylenediaminetetraacetic Acid (EDTA) synthesis
in Germany in 1935. Münz subsequently applied for United States patents in 1936 and
1937 (U.S. Patent Number 2130505); his method involved reacting monochloroacetic acid
(C2H3ClO2) and ethylene diamine (C2H8N2). Concurrent with Münz’s work, Frederick C.
Bersworth in the United States synthesized Ethylenediaminetetraacetic Acid (EDTA) using different methods that gave greater
yields and made EDTA’s commercial production economically viable. Bersworth syntheses
involved reacting formaldehyde, amines, and hydrogen cyanide. Bersworth and Münz obtained
patents for Ethylenediaminetetraacetic Acid (EDTA) production in the 1940s (U.S. Patent Numbers 2407645 and 2461519).
Verwenden
antispasmodic
Definition
An organic chelating agent.
Vorbereitung Methode
Edetic acid may be prepared by the condensation of ethylenediamine
with sodium monochloroacetate in the presence of sodium
carbonate. An aqueous solution of the reactants is heated to about
90°C for 10 hours, then cooled, and hydrochloric acid is added to
precipitate the edetic acid.
Edetic acid may also be prepared by the reaction of ethylenediamine
with hydrogen cyanide and formaldehyde with subsequent
hydrolysis of the tetranitrile, or under alkaline conditions with
continuous extraction of ammonia.
Allgemeine Beschreibung
Ethylenediamine tetraacetic acid is a colorless crystalline solid. Ethylenediaminetetraacetic acid is slightly soluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. Ethylenediaminetetraacetic acid is used in chemical analysis, to make detergents and cleaning compounds, and for many other uses.
Air & Water Reaktionen
Slightly soluble in water.
Landwirtschaftliche Anwendung
EDTA is short for ethylenediamhetetraacetic acid, an amino polycarboxylic acid. It is a tetraprotic acid and is represented as H4Y with four carboxyl groups and two nitrogen atoms acting as ligand sites. Thus the compound is a hexadentate ligand. Ligands include ions such as Cl-, NO
2-and CN- or neutral molecules like NH
3 and H
2O, which possess a lone pair of electrons that can be shared with a metal cation in coordinate covalent bonds.
The water solubility of EDTA is very low and, therefore, its di-sodium salt Na
2H
2Y.2H
2O is commonly used in titrations. The Y
4- forms very stable, one-to-one complexes with practically every metal ion in the Periodic Table. The reactions are carried out in a neutral or alkaline medium as the complex decomposes in acidic medium.
(and hence deterioration) of the food product, (d) to increase the storage life of whole blood by removing free calcium ions (Ca
2+) to inhibit clotting, and (e) for extracting trace elements, especially copper. EDTA metal complexes, such as NaFeEDTA, MnEDTA, ZnEDTA and CuEDTA are used as fertilizers and foliar sprays.
Biologische Aktivit?t
Chelating agent; sequesters di- and trivalent metal ions.
Sicherheitsprofil
Poison by
intraperitoneal route. Experimental
teratogenic and reproductive effects.
Mutation data reported. A general-purpose
chelaung and complexing agent. When
heated to decomposition it emits toxic
fumes of NOx.
Sicherheit(Safety)
Edetic acid and edetates are widely used in topical, oral, and
parenteral pharmaceutical formulations. They are also extensively
used in cosmetics and food products.
Edetic acid is generally regarded as an essentially nontoxic and
nonirritant material, although it has been associated with doserelated
bronchoconstriction when used as a preservative in
nebulizer solutions. It has therefore been recommended that
nebulizer solutions for bronchodilation should not contain edetic
acid.
Edetates, particularly disodium edetate and edetate calcium
disodium, are used in a greater number and variety of pharmaceutical
formulations than the free acid.
Disodium edetate, trisodium edetate, and edetic acid readily
chelate calcium and can, in large doses, cause calcium depletion
(hypocalcemia) if used over an extended period or if administered
too rapidly by intravenous infusion. If used in preparations for the
mouth, they can also leach calcium from the teeth. In contrast,
edetate calcium disodium does not chelate calcium.
Edetate calcium disodium is nephrotoxic and should be used
with caution in patients with renal impairment.
The WHO has set an estimated acceptable daily intake for
disodium edetate in foodstuffs at up to 2.5 mg/kg body-weight.
LD50 (mouse, IP): 0.25 g/kg
LD50 (rat, IP): 0.397 g/kg
m?gliche Exposition
EDTA is a white, odorless, crystalline material or white powder
Environmental Fate
EDTA can be very persistent in water, including wastewatertreatment
plants. EDTA is often found in the receiving waters of
many industrial areas, thus being classified as one of the major
organic pollutants discharged in waters. The available ecotoxicity
data for EDTA indicate that these compounds are slow to
degrade under typical environmental conditions but are not
expected to bioconcentrate. EDTA compounds range from
practically nontoxic to moderately toxic on an acute basis,
depending on the salt. Algae and invertebrates are among the
most sensitive species based on predictive modeling for acute
and chronic endpoints for EDTA, depending on the compound.
EDTA and its salts also do not appear to be very toxic for
terrestrial wild mammals, and adverse effects from reasonably
expected agricultural uses are not expected.
Lager
Although edetic acid is fairly stable in the solid state, edetate salts
are more stable than the free acid, which decarboxylates if heated
above 150°C. Disodium edetate dihydrate loses water of crystallization
when heated to 120°C. Edetate calcium disodium is slightly
hygroscopic and should be protected from moisture.
Aqueous solutions of edetic acid or edetate salts may be sterilized
by autoclaving, and should be stored in an alkali-free container.
Edetic acid and edetates should be stored in well-closed
containers in a cool, dry place.
Versand/Shipping
UN3082 Environmentally hazardous substances,
liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required
l?uterung methode
Dissolve EDTA in aqueous KOH or ammonium hydroxide, and precipitate it twice with dilute HCl or HNO3. Boil it twice with distilled water to remove mineral acid, then recrystallise it from water or dimethylformamide. Dry it at 110o. It also recrystallises from boiling 1N HCl; wash the crystals with distilled H2O and dry them in vacuo. [Ma & Ray Biochemistry 19 751 1980, Beilstein 4 IV 2449.]
Inkompatibilit?ten
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides, copper, copper alloys, and
nickel
Regulatory Status
Included in the FDA Inactive Ingredients Database (oral, otic, rectal,
and topical preparations; submucosal injection preparations).
Included in nonparenteral medicines licensed in the UK. Included
in the Canadian List of Acceptable Non-medicinal Ingredients.
Edetinsure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
