Captafol Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSES KRISTALLINES PULVER.
CHEMISCHE GEFAHREN
Zersetzung beim Erhitzen oder Verbrennen unter Bildung giftiger und ?tzender Rauche mit Chlorwasserstoff(s. ICSC 0163), Stickstoffoxiden, Schwefeloxiden. Reagiert sehr heftig mit Basen unter Feuer- und Explosionsgefahr. Greift einige Metalle an.
ARBEITSPLATZGRENZWERTE
TLV: 0,1 mg/m?(als TWA); Hautresorption; Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den K?rper durch Inhalation und über die Haut.
INHALATIONSGEFAHREN
Verdampfung bei 20 °C vernachl?ssigbar; eine gesundheitssch?dliche Partikelkonzentration in der Luft kann jedoch beim Versprühen oder Dispergieren schnell erreicht werden, besonders als Pulver.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Die Substanz reizt die Augen, die Haut und die Atemwege.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wiederholter oder andauernder Hautkontakt kann zu Dermatitis, zu Hautsensibilisierung und zu allergischer Bindehautentzündung führen. Wiederholte oder andauernde Inhalation kann asthmatische Beschwerden hervorrufen. M?glich sind Auswirkungen auf Leber und Nieren. Wahrscheinlich krebserzeugend für den Menschen.
LECKAGE
NICHT in die Kanalisation spülen. Verschüttetes Material in Beh?ltern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgf?ltig sammeln. An sicheren Ort bringen. Pers?nliche Schutzausrüstung: Atemschutzger?t, P3-Filter für giftige Partikel.
R-S?tze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R43:Sensibilisierung durch Hautkontakt m?glich.
R50/53:Sehr giftig für Wasserorganismen, kann in Gew?ssern l?ngerfristig sch?dliche Wirkungen haben.
S-S?tze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Beh?lter sind als gef?hrlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Chemische Eigenschaften
Captafol is a white crystalline solid.
Verwenden
Captafol is used to control a wide range of fungal diseases on
many crops.
Definition
ChEBI: A dicarboximide that captan in which the trichloromethyl group is replaced by a 1,1,2,2-tetrachloroethyl group. A broad-spectrum fungicide used to control diseases in fruit and potatoes, it is no longer approved for use in the European Community.
Allgemeine Beschreibung
White crystalline solid with a slight, but pungent odor. Mp: 162°C. Practically insoluble in water. Only slightly soluble in organic solvents. Technical CAPTAFOL is a wettable light tan powder that is used as a fungicide. Inhaled dust irritates the respiratory tract. Irritates skin and damages eyes. Acute oral toxicity in humans is low. Not persistent in the environment (decomposes with a half-life of 11 days in the soil). Highly toxic to fish and other aquatic organisms.
Reaktivit?t anzeigen
CAPTAFOL is non-flammable but, on heating, may decompose to generate toxic fumes, such as sulfur oxides, hydrogen sulfide, hydrochloric acid, and phosgene. Stable at room temperature when dry but readily hydrolysed, especially in an alkaline environment. CAPTAFOL and mixtures containing high concentrations of CAPTAFOL may react violently with alkali. Incompatible with acids, acid chlorides, acid anhydrides, and strong oxidizing agents. Sulfhydryl compounds such as glutathione and cysteine cause a rapid chemical decomposition.
Hazard
Absorbed by skin. Probable carcinogen.
Landwirtschaftliche Anwendung
Fungicide: Captafol is a General Use Pesticide and used for the control of practically all forms of fungal diseases except powdery mildew. It is also used as a seed protectorant on cotton, rice and peanut crops. Not registered for use in the U.S. or in EU countries. There are 20 global suppliers.
Handelsname
CAPTATOL®; CAPTOFOL®; CRISFOLATAN®; DIFOLATAN®[C]; DIFOCAP®[C]; DIFOSAN®; FOLCID®; HAIPEN®; KENOFOL®; MERPAFOL®; ORTHO® 5865[C]; PILLARTAN®; SANSEAL®; SANSPOR®; SANTAR-SM®; SULFONIMIDE®; SULPHEIMIDE®
Kontakt-Allergie
Captafol is a pesticide, belonging to thiophthalimide
group. Occupational contact dermatitis was reported in
an agricultural worker who had multiple sensitizations
Sicherheitsprofil
Confirmed carcinogen
with experimental carcinogenic data. Poison
by intraperitoneal route. Moderately toxic by
ingestion. An experimental teratogen. Other
experimental reproductive effects. Mutation
data reported. A fungicide. When heated to
decomposition it emits very toxic fumes of
Cl-, NO,, and SOx
m?gliche Exposition
Captafol is a thiophthalimide fungicide. Those engaged in the manufacture, formulation, and
application of this fungicide. Captafol is not currently registered for use on field crops or stored produce in the
United States.
Carcinogenicity
Captafol is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals and supporting data on mechanisms of carcinogenesis.
Environmental Fate
The primary toxicity following captafol exposure probably
occurs through a hypersensitivity mechanism. Most experiments
suggest captafol to be DNA active.
Stoffwechselwegen
Captafol contains an unstable tetrachloroethylthio (sulfenyl) moiety that
has been shown to undergo rapid hydrolytic and metabolic degradation
to tetrahydrophthalimide (2). By analogy with captan, presumably the
tetrachloroethylthio moiety can be transferred to the sulfur atoms of
thiols such as cysteine and glutathone. Thus in the presence of thiols
such as glutathione, captafol is probably cleaved at the N-S bond to
form thiophosgene (3) and other gaseous products such as hydrogen
sulfide, hydrogen chloride and carbonyl sulfide. Thiophosgene is rapidly
hydrolysed by water. The tetrachloroethylthio group and thiophosgene
are believed to be intermediates in the formation of thiazolidine-2-
thione-6carboxylic acid (4) which is an addition product with cysteine. A
thiazolidine derivative of glutathione is also formed (5). Biotransformation
of captafol in mammals generates primarily thiophosgene (3)
and tetrahydrophthalimide (2). Tetrahydrophthalimide (2) and various
of its derivatives are excreted in the urine. There were no reports of
2-thiazolidinethione-4-carboxylic acid (4) in the urine.
Versand/Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. UN 2773 Phthalimide derivative pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous
materials, Technical Name Required.
Inkompatibilit?ten
Reacts violently with bases, causing fire
and explosion hazard. Not compatible with strong acids or
acid vapor, oxidizers. Strong alkaline conditions contribute
to instability. Attacks some metals.
Waste disposal
Hydrolysis.
Captafol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
