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DL-Sulforaphane

DL-Sulforaphane Struktur
4478-93-7
CAS-Nr.
4478-93-7
Englisch Name:
DL-Sulforaphane
Synonyma:
sulforaphane;SULPHORAPHANE;sulforaphan;-SuL;foraphane;sulforafan;Sulforaphen;Detoxophane;sulforphane;S-SULFORAPHANE
CBNumber:
CB9765544
Summenformel:
C6H11NOS2
Molgewicht:
177.29
MOL-Datei:
4478-93-7.mol

DL-Sulforaphane Eigenschaften

Siedepunkt:
125-135°C
Dichte
1.17±0.1 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
DMSO: 40 mg/mL, soluble
Aggregatzustand
liquid
Farbe
slightly yellow
Stabilit?t:
Light Sensitive
LogP
0.407 (est)
CAS Datenbank
4478-93-7(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
S-S?tze: 23-24/25
WGK Germany  3
HS Code  29309090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P337+P313 Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

DL-Sulforaphane Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Sulforaphane is a compound within the isothiocyanate group of organosulfur compounds and mainly found in cruciferous vegetables. It is produced when the enzyme myrosinase transforms glucoraphanin,a prodrug or storage form of SFN, into SFN upon damage to the plant (such as from chewing),which allows the two compounds to mix and react. Glucoraphanin is one of a few molecules known as isothiocyanates, existing alongside Sinigrin (metabolized into allylisothiocyanate).

Chemische Eigenschaften

DL-Sulforaphane (SFN) is a slightly yellow liquid. soluble in DMSO, methanol, or water-like solvents. SFN exists in food in its food-bound form known as Glucoraphanin. It is present in a wide range of vegetables such as cabbage, cauliflower, bok choy, kale, chinese broccoli, mustard, turnip, radish, and watercress.

Verwenden

Potent, selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Occurs naturally in broccoli. It was found to inhibit chemically induced mammary tumor formation in rats. Antitumor agent
LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor. Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.
Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress.
Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1.
Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents.
Sulforaphane is an isothiocyanate derived from cruciferous vegetables, including broccoli, that potently induces chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression.
At 15 μM, sulforaphane inhibits class I and II HDAC activity and suppresses tumor growth by inducing cell cycle arrest and apoptosis selectively in various cancerous prostate epithelial cells without affecting normal cells.
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells

Definition

ChEBI: Sulforaphane is an isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen. It has a role as an antineoplastic agent, a plant metabolite, an antioxidant and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a sulfoxide and an isothiocyanate.

Allgemeine Beschreibung

An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. It has been shown to be an effective agent in prevention of chemically-induced mammary tumors in rats. It also inhibits the phase I cytochrome P450 isoenzymes 2E1 and IA2 which have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by mitogen-activated protein kinase (MAPK) pathway.

Biologische Aktivit?t

Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.
Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables. It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.

DL-Sulforaphane Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


DL-Sulforaphane Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 319)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu Greenpure Biopharma CO.,Ltd
18283602253; +8618283602253
jancyzheng@gcgreenpure.com China 953 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Hebei Kingfiner Technology Development Co.Ltd
+86-15532196582 +86-15373005021
lisa@kingfinertech.com China 3010 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
+86-18791163155 +86-13119157289
13119157289@163.com China 2973 58
BINBO BIOLOGICAL CO.,LTD
+8618629063126
info@binbobiological.com China 423 58
Hangzhou Lin'an tianhong biotechnology co.,ltd.
+86-0571-58605786 +8617758008775
admin@tianhongsw.com China 44 58
Hebei Zhuanglai Chemical Trading Co Ltd
+86-16264648883 +86-16264648883
niki@zlchemi.com China 2691 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58

4478-93-7()Verwandte Suche:


  • sulforafan
  • R-SULFORAPHANE
  • R,S-SULFORAPHANE
  • SULFORAPHANE, L-
  • SULFORAPHANE, DL-
  • SULFORAPHANE, D-
  • S-SULFORAPHANE
  • Methyl(4-isothiocyanatobutyl) sulfoxide
  • Sulforaphen
  • (-)-ISOTHIOCYANATO-(4R)-(METHYLSULFINYL)BUTANE
  • DL-SULPHORAPHANE
  • DL-SULFORAPHANE
  • D-SULFORAPHANE
  • (-)-(4R)-SULFORAPHANE
  • 4-METHYLSULFINYLBUTYL ISOTHIOCYANATE
  • 1-ISOTHISCYANATO-4-(METHYLSULFINYL)-BUTANE
  • 1-ISOTHIOCYANATO-4-(METHYLSULFINYL)-BUTANE
  • (-)1-ISOTHIOCYANATO-4S-(METHYLSULFINYL)-BUTANE
  • (+)1-ISOTHIOCYANATO-4S-(METHYLSULFINYL)-BUTANE
  • ((-)1-ISOTHIOCYANATO-4R-METHYLSULFINYL)BUTANE
  • 1-ISOTHIOCYANATO-4-(METHYLSULFIYL)-BUTANE
  • (+)-1-ISOTHIOCYANATE-4R(METHYLSULFINYL)-BUTANE
  • 4-methylsulfinylbutylimino(thioxo)methane
  • DL-Sulforaphane,1-Isothiocyanato-4-(methylsulfinyl)-butane
  • Detoxophane
  • DL-Sulforaphan
  • Butane,1-isothiocyanato-4-(Methylsulfinyl)-
  • Broccoli Seed Extract/Sulforaphane/Brassica oleracea extract
  • DL-Sulforaphane 4478-93-7
  • Sulforaphane Racemate
  • D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem
  • sulforphane
  • Sulforaphane 1-13% (powder)
  • foraphane
  • -SuL
  • DL-SULFORAPHANE USP/EP/BP
  • Sulforaphane (liquid)
  • Sulforaphane (BroccoPhane
  • broccoli sulforaphane
  • Sulforaphane (DL-Sulforaphane)
  • Sulforaphane Extract
  • Sulforafan Extract
  • sulforaphan
  • sulforaphane
  • SULPHORAPHANE
  • DL-Sulforaphane (AS)
  • Dl-Sulforaphane 0.5%
  • Sulforaphen Powder 10%
  • 4478-93-7
  • 142815-10-3
  • 42825-10-3
  • 4487-93-7
  • C6H11NOS2
  • Cancer Research
  • Chemopreventive Agents
  • BioChemical
  • Phase II Enzyme Inducers
  • Aliphatics
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