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3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2. 1)octanbromid,(endo,syn)-(+-)-

Ipratropium bromide Struktur
22254-24-6
CAS-Nr.
22254-24-6
Bezeichnung:
3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2. 1)octanbromid,(endo,syn)-(+-)-
Englisch Name:
Ipratropium bromide
Synonyma:
Ipratropium;Ipratropium Bromide anhydrous;atrovent;IPRATROPIUM BROMIDE EP;[(1r,5s)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate bromide;atem;pate;PATE1;itrop;YB-API
CBNumber:
CB9715938
Summenformel:
C20H30NO3.Br
Molgewicht:
412.36
MOL-Datei:
22254-24-6.mol

3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2. 1)octanbromid,(endo,syn)-(+-)- Eigenschaften

Schmelzpunkt:
230-232°C
Dichte
0.9993 g/cm3
RTECS-Nr.
YM3700000
storage temp. 
Inert atmosphere,Room Temperature
L?slichkeit
H2O: 10 mg/mL
Aggregatzustand
powder
Farbe
white
Wasserl?slichkeit
Freely soluble
Stabilit?t:
Stable. Incompatible with strong oxidizing agents.
CAS Datenbank
22254-24-6(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 20/22-36
S-S?tze: 26
WGK Germany  3
Toxizit?t LD50 in male, female mice (mg/kg): 1001, 1083 orally; 12.29, 14.97 i.v.; 300, 340 s.c.; LD50 in male, female rats (mg/kg): 1663, 1779 orally; 15.89, 15.70 i.v. (Sarafana)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H332 Gesundheitssch?dlich bei Einatmen. Akute Toxizit?t inhalativ Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P271, P304+P340, P312
Sicherheit
P261 Einatmen von Staub vermeiden.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2. 1)octanbromid,(endo,syn)-(+-)- Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/22:Gesundheitssch?dlich beim Einatmen und Verschlucken.
R36:Reizt die Augen.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

White Powder

Verwenden

Ipratropium Bromide is a nonselective muscarinic acetylcholine receptor antagonist; bronchodilator.

Definition

ChEBI: The anhydrous form of the bromide salt of ipratropium. An anticholinergic drug, ipratropium bromide blocks the muscarinic cholinergic receptors in the smooth muscles of the bronchi in the lungs. This opens the bronchi, so providing relief in chronic obstru tive pulmonary disease and acute asthma.

Allgemeine Beschreibung

Ipratropium bromide, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane bromide (Atrovent), is a quaternaryammonium derivative of atropine. It is freely soluble inwater and ethanol but insoluble in chloroform and ether. Thesalt is stable in neutral and acidic solutions but rapidly hydrolyzedin alkaline solutions.

Biologische Aktivit?t

Muscarinic antagonist, bronchodilator. N-Isopropyl salt of atropine.

Clinical Use

Ipratropium bromide is used in inhalation therapy toproduce dilation of bronchial smooth muscle for acute asthmaticattacks. The drug produces bronchodilation by competitiveinhibition of cholinergic receptors bound to smooth muscle of the bronchioles. Ipratropium may also act on thesurface of mast cells to inhibit ACh-enhanced release ofchemical mediators. The drug has a slow onset of action,within 5 to 15 minutes after being administered by inhalation,and should not be used alone for acute asthmatic attacks.The peak therapeutic effect from one dose is observedbetween 1 and 2 hours. The effects of the drug last for about6 hours. It has a half-life of 3.5 hours.

3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2. 1)octanbromid,(endo,syn)-(+-)- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Brommethan endo-(±)-8-Aza-8-isopropylbicyclo[3.2.1]oct-3-yl-(hydroxymethyl)phenylacetat

Downstream Produkte

3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2. 1)octanbromid,(endo,syn)-(+-)- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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22254-24-6(3-(3-Hydroxy-1-oxo-2-phenylpropo-xy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2. 1)octanbromid,(endo,syn)-(+-)-)Verwandte Suche:

  • N-Isopropylatropinium bromide
  • Sch 100
  • IPTRATROPIUM BROMIDE
  • Ipratropium bromide
  • (endo,syn)-(±)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octanebromide
  • Ipratropium bromide monohydrate,Atropine isopropyl bromide
  • (3-endo,8-syn)-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane, bromide (1:1)
  • ANTI-PATE1 (C-TERM) antibody produced in rabbit
  • PATE1
  • Prostate and testis expressed protein 1
  • (1s,3s,5r)-3-tropyloxy-8-isopropyltropaniumbromide
  • (8r)-3-alpha-hydroxy-8-isopropyl-1-alpha-h,5-alpha-h-tropiumbromide-(+-)-tro
  • 1-alpha-h,5-alpha-h-tropanium,3-alpha-hydroxy-8-isopropyl-,bromide,(+-)-trop
  • 3-alpha-hydroxy-8-isopropyl-1-alpha-h,5-alpha-h-tropaniumbromide(+-)-tropat
  • 8-isopropylnoratropinemethobromide
  • atem
  • ipratropiumbromid
  • itrop
  • n-isopropylnoratropiniumbromomethylate
  • pate
  • sch1000
  • IPRATROPIUM BROMIDE HYDRATE
  • (ENDO,SYN)-(+/-)-3-(3-HYDROXY-1-OXO-2-PHENYLPROPOXY)-8-METHYL-8-(1-METHYLETHYL)-8-AZONIABICYCLO[3.2.1]OCTANE BROMIDE
  • ATROPINE ISOPROPYLBROMIDE
  • Atropine Isopropyl Bromid
  • IPRATROPIUMBROMIDE,BP,EP
  • 1αH,5αH-Tropanium, 3α-hydroxy-8-isopropyl-, bromide, (+-)-tropate (8CI)
  • 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, (3-endo,8-syn)-
  • 3-(3-HYDROXY-1-OXO-2-PHENYLPROPOXY)-8-METHYL-8-(1-METHYLETHYL)-8-AZONIABICYCLO[3.2.1]-OCTANE BROMIDE
  • (3-endo,8-syn)-3-(3-Hydroxy-1-oxo-2-phenylpropyl)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane Bromode Monohydrate
  • 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, (endo,syn)-, bromide
  • 8-Isopropylatropinium bromide
  • 3-alpha-Hydroxy-8-isopropyl-1-alpha-H,5-alpha-H-tropanium bromide (±)-tropate
  • 2-Methyl-2-[(piperidinomethyl)thio]propionic acid
  • 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, (endo,syn)-
  • 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, (endo,syn)-(+-)-
  • 8-Isopropylatropinium bromide (6CI, 7CI)
  • Atrovent forte
  • Ipratropium D3
  • 3-hydroxy-2-phenylpropanoic acid [(1S,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] ester bromide hydrate
  • Ipratropium bromide USP/EP/BP
  • Ipratropium bromide salt
  • Ipratropium Bromide (Sch 1000)
  • Ipratropium BromideQ: What is Ipratropium Bromide Q: What is the CAS Number of Ipratropium Bromide Q: What is the storage condition of Ipratropium Bromide Q: What are the applications of Ipratropium Bromide
  • Ipratropium Bromide anhydrous
  • atrovent
  • Ipratropium
  • IPRATROPIUM BROMIDE EP
  • [(1r,5s)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate bromide
  • 2H6]-Ipratropium bromide salt
  • Atrovent Hfa
  • YB-API
  • rel-(1R,3r,5S,8s)-3-((3-Hydroxy-2-phenylpropanoyl)oxy)-8-isopropyl-8-methyl-8-azabicyclo[3.2.1]octan-8-ium bromide
  • 8-Azoniabicyclo[3.2.1]octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide (1:1), (3-endo,8-syn)-
  • 22254-24-6
  • 2254-24-6
  • 47526-32-7
  • C20H30NO3BrH2O
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