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Altretamin

Altretamine Struktur
645-05-6
CAS-Nr.
645-05-6
Bezeichnung:
Altretamin
Englisch Name:
Altretamine
Synonyma:
HMM;HTM;Hemel;NC 195;Hexylen;Hexalen;RB-1515;ent50852;Hexastat;nsc13875
CBNumber:
CB9480937
Summenformel:
C9H18N6
Molgewicht:
210.28
MOL-Datei:
645-05-6.mol

Altretamin Eigenschaften

Schmelzpunkt:
171-175 °C (lit.)
Siedepunkt:
339.81°C (rough estimate)
Dichte
1.0441 (rough estimate)
Brechungsindex
1.6100 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
L?slichkeit
Chloroform (Sparingly), Methanol (Slightly, Heated)
Aggregatzustand
solid
pka
pKa 10.3 (Uncertain)
Farbe
White to Off-White
Wasserl?slichkeit
Insoluble
Merck 
13,318
CAS Datenbank
645-05-6(CAS DataBase Reference)
NIST chemische Informationen
Altretamine(645-05-6)
EPA chemische Informationen
Altretamine (645-05-6)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-36/37/38
S-S?tze: 26-36
WGK Germany  3
RTECS-Nr. OS1050000
HS Code  2933690000
Giftige Stoffe Daten 645-05-6(Hazardous Substances Data)
Toxizit?t LD50 in rats, guinea pigs (mg/kg): 350, 255 orally (Jasper)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Altretamin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

White Solid

Verwenden

An antitumor agent which also acts as a chemosterilant for male houseflies and other insects. Antineoplastic.

Definition

A hexamethyl-2,4,6- triamine derivative of 1,3,5-triazine.

Indications

Although both DNA and RNA synthesis are inhibited in cells exposed to hexamethylmelamine (Hexalen), the molecular mechanisms of these effects are not known.

Allgemeine Beschreibung

Altretamine is available in 50-mg capsules for oraladministration as a second-line treatment for ovarian cancer.The mechanism of action has not been firmly established, althoughthe spectrum of activity is similar to that for otheralkylating agents; however, cross-resistance is not seen.Cytotoxicity has been correlated with metabolism to give thecarbinolamines, which may form imines capable of crosslinking,or decompose to give formaldehyde, which may reactwith nucleophiles on DNA or proteins. The agent is well absorbedupon oral administration, well distributed, and highly(90%) plasma protein bound. The agent is extensively metabolizedin the liver by CYP to give demethylated metabolites via the previously mentioned carbinolamines. Elimination occursprimarily in the urine as mostly demethylated metaboliteswith a terminal elimination half-life of 4 to 10 hours.Myleosuppression and nausea/vomiting are dose-limitingtoxicities. Other adverse effects include lethargy, agitation,hallucinations, skin rash, and elevations in transaminase levels,flulike symptoms, abdominal cramps, and diarrhea.

Air & Water Reaktionen

Insoluble in water.

Reaktivit?t anzeigen

Altretamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Hazard

Toxic.

Mechanism of action

Hexamethylmelamine is readily absorbed after oral administration, with peak plasma levels achieved after 1 hour.The drug is readily metabolized to form a number of demethylated metabolites. Urinary elimination is the primary route of drug excretion.

Clinical Use

Hexamethylmelamine is useful for the treatment of ovarian adenocarcinoma and is frequently combined with cyclophosphamide, cisplatin, and doxorubicin in the treatment of this tumor. It also has some activity against small cell lung cancer.

Nebenwirkungen

Nausea and vomiting are the major toxicities associated with hexamethylmelamine administration. Myelosuppression and a peripheral neuropathy also may occur.

Stoffwechsel

This unique structure is believed to damage tumor cells through the production of the weakly alkylating species formaldehyde, a product of CYP450-mediated N-demethylation. Administered orally, altretamine is extensively metabolized on first pass, producing primarily mono- and didemethylated metabolites. Additional demethylation reactions occur in tumor cells, releasing formaldehyde in situ before the drug is excreted in the urine.

Altretamin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Altretamin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 213)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Anhui Ruihan Technology Co., Ltd
+8617756083858
daisy@anhuiruihan.com China 973 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58

645-05-6(Altretamin)Verwandte Suche:


  • 2,4,6-Tris(dimethylamino)-1,3,5-triazine 96%
  • 1,3,5-Triazine-2,4,6-triamine, N,N,N',N',N'',N''-hexamethyl-
  • 1,3,5-tris(dimethylamino)-s-triazine
  • 2,4,6-tris(dimethylamino)-s-triazin
  • 2,4,6-Tris(Dimethylamino)-s-triazine
  • 5-triazine-2,4,6-triamine,n,n,n’,n’,n’’,n’’-hexamethyl-3
  • HEXAMETHYLMELAMINE
  • Altretamine, >=99%
  • 2,4,6-TRIS(DIMETHYLAMINO)-1,3,5-TRIAZINE
  • ALTRETAMIN
  • ALTRETAMINE
  • N,N,N',N',N'',N''-HEXAMETHYL-1,3,5-TRIAZINE-2,4,6-TRIAMINE
  • ALTRETAMINE [2,4,6-TRIS(DIMETHYLAMINO)-1,3,5-TRIAZINE]
  • ALTRETAMINE, Hexamethylmelamine
  • [4,6-bis(dimethylamino)-s-triazin-2-yl]-dimethyl-amine
  • 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine
  • N2,N2,N4,N4,N6,N6-hexamethyl-1,3,5-triazine-2,4,6-triamine
  • 6-Tris(diMethylaMino)-1
  • AltretaMine [2
  • AltretaMine, USP
  • Altretamine (500 mg)
  • AltretaMine(Hexalen)
  • Hexylen
  • Aitretamine
  • ENT 50852
  • ENT050852
  • ent50852
  • Hemel
  • Hexalen
  • hexamethyl-melamin
  • Hexastat
  • HMM
  • HTM
  • Melamine, hexamethyl-
  • melamine,hexamethyl-
  • NC 195
  • NCI-C50259
  • NSC 13875
  • nsc13875
  • NSC-13875
  • s-Triazine, 2,4,6-tris(dimethylamino)-
  • RB-1515
  • WR-95704
  • Altretamine (RB-1515,WR-95704)
  • 1,3,5-Triazine-2,4,6-triamine, N2,N2,N4,N4,N6,N6-hexamethyl-
  • Altretamine USP/EP/BP
  • Altretamine (ENT-50852)
  • Altretamine (1017105)
  • HSDB 1402
  • Hexamethylmelamine|||NSC13875|||RB-1515|||ENT-50852|||WR-95704
  • 645-05-6
  • C9H18N6
  • C9H24N6
  • Heterocyclic Building Blocks
  • DNA Intercalators and Crosslinkers
  • DNA metabolism
  • Triazines
  • Building Blocks
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