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Pyridostigminbromid

Mestinon Struktur
101-26-8
CAS-Nr.
101-26-8
Bezeichnung:
Pyridostigminbromid
Englisch Name:
Mestinon
Synonyma:
PYRIDOSTIGMINE BROMIDE;PYBR;3-(DIMETHYLCARBAMOYLOXY)-1-METHYLPYRIDINIUM BROMIDE;kalymin;regonal;kalimin;ro1-5130;mestinon;3-Hydroxy-1-;mestinonbromide
CBNumber:
CB9356274
Summenformel:
C9H13BrN2O2
Molgewicht:
261.12
MOL-Datei:
101-26-8.mol

Pyridostigminbromid Eigenschaften

Schmelzpunkt:
154 °C
storage temp. 
2-8°C
L?slichkeit
Very soluble in water and in ethanol (96 per cent).
Aggregatzustand
Solid
Farbe
White to Almost white
Merck 
14,7977
BCS Class
3
InChIKey
VNYBTNPBYXSMOO-UHFFFAOYSA-M
CAS Datenbank
101-26-8(CAS DataBase Reference)
EPA chemische Informationen
Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1) (101-26-8)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T+
R-S?tze: 26/27/28-43
S-S?tze: 22-36/37/39-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS-Nr. UU5270000
HazardClass  6.1
PackingGroup  II
HS Code  2933399090
Giftige Stoffe Daten 101-26-8(Hazardous Substances Data)
Toxizit?t man,TDLo,oral,9mg/kg (9mg/kg),PERIPHERAL NERVE AND SENSATION: FASCICULATIONS,Israel Journal of Medical Sciences. Vol. 27, Pg. 659, 1991.
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Sicherheit
P262 Nicht in die Augen, auf die Haut oder auf die Kleidung gelangen lassen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Pyridostigminbromid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R43:Sensibilisierung durch Hautkontakt m?glich.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Pyridostigmine is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.35 and 1 μM, respectively, for the human enzymes). Pyridostigmine (10 μM) reduces decreases in AChE activity induced by the organophosphate pesticides diisopropyl fluorophosphate, chlorpyrifos-oxon, diazinon-oxon, paraoxon, and malaoxon in isolated bovine red blood cells. It also reduces soman-induced membrane depolarization and decreases in AChE activity in isolated human muscle bundles in a concentration-dependent manner. Pyridostigmine (3 mg/kg per day for four weeks) prevents tachycardia and increases in sympathetic tone in mice following myocardial infarction induced by left coronary artery ligation. Formulations containing pyridostigmine have been used in the treatment of myasthenia gravis and as neuromuscular protective agents against organophosphate poisoning.

Chemische Eigenschaften

White Solid

Verwenden

Cholinergic, used in the treatment of myasthenia gravis, and is a pre-exposure antidote to chemical warfare agents.

Allgemeine Beschreibung

Pyridostigmine bromide,3-hydroxy-1-methylpyridinium bromide dimethylcarbamateor pyridostigmine bromide (Mestinon), occurs as a white, hygroscopic,crystalline powder with an agreeable, characteristicodor. It is freely soluble in water, alcohol, and chloroform.
Pyridostigmine bromide is about one fifth as toxic asneostigmine. It appears to function in a manner similar tothat of neostigmine and is the most widely used anticholinesteraseagent for treating myasthenia gravis. Theliver enzymes and plasma cholinesterase metabolize thedrug. The principal metabolite is 3-hydroxy-N-methylpyridinium.Orally administered pyridostigmine has a half-lifeof 90 minutes and a duration of action of between 3 and6 hours.

Pyridostigminbromid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pyridostigminbromid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 338)Lieferanten
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Capot Chemical Co.,Ltd.
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Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
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+8615858145714
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sales@sdzschem.com China 2930 58
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18871490254
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027-85778276
info@chemwonders.com CHINA 176 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5906 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58

101-26-8(Pyridostigminbromid)Verwandte Suche:


  • mestinonbromide
  • mestinonebromide
  • pyridinium,3-hydroxy-1-methyl-,bromide,dimethylcarbamate(ester)
  • pyridinium,3-hydroxyl-1-methyl-,bromide,dimethylcarbamate
  • regonal
  • ro1-5130
  • 1-methyl-3-hydroxypyridiniumbromidedimethylcarbamate
  • PYRIDOSTIGMINEBROMIDE,USP
  • Pyridostigminbromid
  • (1-Methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate bromide
  • 2-Propan-2-ylsulfanylethanol
  • 3-Hydroxy-1-
  • N,N-dimethylcarbamic acid (1-methylpyridin-1-ium-3-yl) ester bromide
  • PyridostigminebromideBP/USP
  • PYRIDOSTIGMINE BROMIDE CHOLINESTERASE IN HIBI
  • Pyridostigmine bromide,3-(Dimethylaminocarbonyloxy)-1-methylpyridinium bromide
  • Pyridostigmine Bromide (200 mg)
  • Pyridostigmine Bromide (200 mg)I0C3240.999mg/mg(dr)
  • 3-diMethylaMino pyridine acyloxy
  • 3-(((dimethylamino)carbonyl)oxy)-1-methyl-pyridiniubromide
  • 3-(dimethylcarbamyloxy)-1-methylpyridiniumbromide
  • 3-hydroxy-1-methylpyridiniumbromidedimethylcarbamate
  • 3-hydroxy-1-methylpyridiniumbromidedimethylcarbamate(ester)
  • dimethylcarbamicacidesterof3-hydroxy-1-methylpyridiniumbromide
  • kalimin
  • 3-(DIMETHYLAMINOCARBONYLOXY)-1-METHYLPYRIDINIUM BROMIDE
  • 3-DIMETHYLAMINOCARBONYLOXY-N-METHYL-PYRIDINIUM BROMIDE
  • mestinon
  • 3-[(diMethylcarbaMoyl)oxy]-1-Methylpyridin-1-iuM
  • 3-[[(DiMethylaMino)carbonyl]oxy]-1-MethylpyridiniuM BroMid
  • 3-((diMethylcarbaMoyl)oxy)-1-Methylpyridin-1-iuM broMide
  • PyridostigMine BroMide (Mestinon)
  • BroMine pyridostigMine
  • Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1)
  • (1-methylpyridin-1-ium-3-yl) N,N-dimethylcarbamate
  • Pyridostigminebromide(NTPB)
  • Pyridostigmine bromide CRS
  • [2H6]-Pyridostigmine Bromide
  • Mestinon USP/EP/BP
  • Pyridostigmine D6 BromideQ: What is Pyridostigmine D6 Bromide Q: What is the CAS Number of Pyridostigmine D6 Bromide Q: What is the storage condition of Pyridostigmine D6 Bromide Q: What are the applications of Pyridostigmine D6 Bromide
  • Pyridostigmine bromide (P4099900)
  • Pyridostigmine Bromide (1586009)
  • 2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1
  • 2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid
  • 4-dihydropyridine-3-carboxylic acid
  • PYRIDOSTIGMINE BROMIDE
  • PYBR
  • kalymin
  • 3-(DIMETHYLCARBAMOYLOXY)-1-METHYLPYRIDINIUM BROMIDE
  • Pyridamine bromide
  • Pyridostigmine Bromide, ≥ 98.0%
  • 101-26-8
  • C9H13BrN2O2
  • Pyridinium Compounds
  • Pharmaceutical raw material
  • API
  • MESTINON
  • Pyridinium Compounds
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