4-PHENOXYPHENYLBORONIC ACID
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- CAS-Nr.
- 51067-38-0
- Englisch Name:
- 4-PHENOXYPHENYLBORONIC ACID
- Synonyma:
- EOS-61617;AKOS BRN-0132;RARECHEM AH PB 0260;TIMTEC-BB SBB003409;Ibrutinib Impurity 36;4-PHENOXYPHENYLBORONI;4-Boronodiphenyl ether;4-PHENOXYPHENYLBORONIC;4-phenoxy-phenylboric acid;4-PHENOXYPHENYLBORONIC ACID
- CBNumber:
- CB9278200
- Summenformel:
- C12H11BO3
- Molgewicht:
- 214.02
- MOL-Datei:
- 51067-38-0.mol
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4-PHENOXYPHENYLBORONIC ACID Eigenschaften
- Schmelzpunkt:
- 141-145 °C(lit.)
- Siedepunkt:
- 377.0±44.0 °C(Predicted)
- Dichte
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- soluble in Methanol
- pka
- 8.76±0.10(Predicted)
- Aggregatzustand
- Crystalline Powder
- Farbe
- White to beige
- InChI
- InChI=1S/C12H11BO3/c14-13(15)10-6-8-12(9-7-10)16-11-4-2-1-3-5-11/h1-9,14-15H
- InChIKey
- KFXUHRXGLWUOJT-UHFFFAOYSA-N
- SMILES
- B(C1=CC=C(OC2=CC=CC=C2)C=C1)(O)O
- CAS Datenbank
- 51067-38-0(CAS DataBase Reference)
4-PHENOXYPHENYLBORONIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white to off-white powder and chunk
Verwenden
4-Phenoxyphenylboronic acid can be used as a reactant:
- In the Suzuki-Miyaura coupling reaction to synthesize aryl derivatives via C-C bond formation by reacting with different aryl halides over a palladium catalyst.
- To prepare 1-phenoxy-4-(trifluoromethyl)benzene via oxidative trifluoromethylation using Chan-Lam-type reaction conditions.
- To synthesize evobrutinib, a potent Bruton′s tyrosine kinase (BTK) inhibitor.
Synthese
4-Bromodiphenyl ether (100 g, 0.402 mol)Was dissolved in anhydrous THF (800 mL)Under nitrogen protection,Cooled to -78 ° C,N-butyllithium (n-BuLi) (177 mL, 0.442 mol)The temperature is kept below -65 ° C,After stirring for 1 h,Continue to maintain the temperature -60 ,Triisopropyl borate (90 g, 0.482 mol) was added dropwise,Slowly rose to 0 ° C, stir for 3 h.Water (300 mL) was added under ice bath overnight. The reaction solution was concentrated to remove the organic phase,With 12N concentrated hydrochloric acid pH adjusted to 1 ~ 2,Precipitation of solids,Filtration and drying gave 4-phenoxyphenylboronic acid (77 g, yield 90%).
4-PHENOXYPHENYLBORONIC ACID Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-PHENOXYPHENYLBORONIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 387)Lieferanten
51067-38-0()Verwandte Suche:
- 4-PHENOXYBENZENEBORONIC ACID
- 4-PHENOXYPHENYLBORONIC ACID
- AKOS BRN-0132
- RARECHEM AH PB 0260
- (P-PHENOXYPHENYL)BORONIC ACID
- TIMTEC-BB SBB003409
- 4-Phenoxybenzeneboronic acid 98%
- 4-Phenoxyphenylboronic acid,97%
- 4-Phenoxyphenylboronic acid ,98%
- 4-Phenoxyphenylboronic Acid (contains varying aMounts of Anhydride)
- 4-Phenoxyphenylboronic acid, 97% 1GR
- 4-Boronodiphenyl ether
- 4-Phenoxyphenylboronic acid >=95.0%
- EOS-61617
- 4-Phenoxyphenylboronic acid Ibrutinib
- Ibrutinib Impurity 36
- 4-Phenoxyphenylboronic acid, 98%, for synthesis
- Boronic acid, B-(4-phenoxyphenyl)-
- 4-PHENOXYPHENYLBORONI
- 4-phenoxy-phenylboric acid
- 4-PHENOXYPHENYLBORONIC
- 51067-38-0
- C12H11BO3
- Aryl
- Boronic Acids
- Boronic Acids and Derivatives
- Organometallic Reagents
- blocks
- BoronicAcids
- Heterocyclic Compounds
- Aryl
- Organoborons
- Boronic Acids
- Boronic Acids and Derivatives
- Boronic Acids
