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OTAVA-BB 7070707015

OTAVA-BB 7070707015 Struktur
934593-90-5
CAS-Nr.
934593-90-5
Englisch Name:
OTAVA-BB 7070707015
Synonyma:
W6;LW8;LW6;CAY10585;CAY10585,LW6;LW6(CAY10585);HIF-1α inhibitor;HIF-1α inhibitor;OTAVA-BB 7070707015;CAY 10585;CAY-10585;CAY10585;LW6
CBNumber:
CB92452396
Summenformel:
C26H29NO5
Molgewicht:
435.51
MOL-Datei:
934593-90-5.mol

OTAVA-BB 7070707015 Eigenschaften

Siedepunkt:
647.4±55.0 °C(Predicted)
Dichte
1.295±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO:17.5(Max Conc. mg/mL);40.18(Max Conc. mM)
DMF:25.6(Max Conc. mg/mL);58.8(Max Conc. mM)
pka
7.59±0.48(Predicted)
Aggregatzustand
powder to crystal
Farbe
White to Light yellow to Light orange

Sicherheit

HS Code  2924.29.7790

OTAVA-BB 7070707015 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor composed of a HIF-1α subunit and HIF-1β subunit. Whereas the HIF-1β subunit is constitutively expressed, the HIF-1α subunit is regulated by cellular oxygen levels and therefore plays an important role in maintaining cellular oxygen homeostasis. Under normoxic conditions, HIF-1α is selectively hydroxylated on proline residues 402 and 577 and targeted for destruction by the ubiquitin-proteasome system. Under hypoxic conditions, HIF-1α accumulates and dimerizes with HIF-1β to promote the transcription of a number of genes involved in angiogenesis, glycolysis, growth factor signaling, tumor invasion, and metastasis. CAY10585 is a novel small molecule inhibitor of HIF-1α accumulation and gene transcriptional activity. In a gene reporter assay using human Hep3B and AGS cell lines, CAY10585 prevented HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 μM, respectively. It blocks HIF-1α accumulation in Hep3B cells in a concentration and time-dependent manner, with complete inhibition at a concentration of 30 μM within 12 hours. CAY10585 also significantly suppresses transcription of the HIF-1 target genes VEGF and erythropoietin at 10 μM.

Verwenden

CAY10585 is a class of hypoxia-inducible factor (HIF-1) responsible for radiation resistance and poor prognosis in cancer therapy.

OTAVA-BB 7070707015 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


OTAVA-BB 7070707015 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 82)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289
contact@trustwe.com China 5738 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Shenzhen Shengda Pharma Limited
755-85269922 +8613424394241
sales@shengdapharm.com CHINA 310 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd
+8618235132063
sales@tihondan.com China 3741 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58

934593-90-5()Verwandte Suche:


  • OTAVA-BB 7070707015
  • CAY10585
  • HIF-1α inhibitor
  • LW6
  • LW8
  • 4-Hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]aMino]-benzoic Acid Methyl Ester
  • Hypoxia inducible factor-1α inhibitor
  • CAY 10585;CAY-10585;CAY10585;LW6
  • LW 6 (This product is unavailable in the U.S.)
  • methyl 3-(2-(4-((1r,3r,5r,7r)-adamantan-2-yl)phenoxy)acetamido)-4-hydroxybenzoate
  • W6
  • Benzoic acid, 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]-, methyl ester
  • Methyl 3-[[[4-(adamantan-1-yl)phenoxy]acetyl]amino]-4-hydroxybenzoate
  • 3-[[[4-(Adamantan-1-yl)phenoxy]acetyl]amino]-4-hydroxybenzoic Acid Methyl Ester
  • methyl 3-(2-(4-(adamantan-1-yl)phenoxy)acetamido)-4-hydroxybenzoate
  • CAY10585,LW6
  • HIF-1α inhibitor
  • LW 6,Apoptosis,LW-8,Hypoxia-inducible factors,inhibit,HIF-PH,HIF/HIF Prolyl-Hydroxylase,LW6,LW-6,HIFs,Inhibitor,LW 8
  • LW6(CAY10585)
  • 934593-90-5
  • Aromatics, Inhibitors
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