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ChemicalBook >> CAS DataBase List >>OTAVA-BB 7070707015

OTAVA-BB 7070707015

CAS No.
934593-90-5
Chemical Name:
OTAVA-BB 7070707015
Synonyms
W6;LW8;LW6;CAY10585;CAY10585，LW6;LW6(CAY10585);HIF-1α inhibitor;HIF-1α inhibitor;OTAVA-BB 7070707015;CAY 10585;CAY-10585;CAY10585;LW6
CBNumber:
CB92452396
Molecular Formula:
C26H29NO5
Molecular Weight:
435.51
MDL Number:
MFCD09907563
MOL File:
934593-90-5.mol
MSDS File:
SDS
Last updated:2024-11-11 20:33:26

OTAVA-BB 7070707015 Properties

Boiling point 647.4±55.0 °C(Predicted)
Density 1.295±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:17.5(Max Conc. mg/mL);40.18(Max Conc. mM)
DMF:25.6(Max Conc. mg/mL);58.8(Max Conc. mM)
pka 7.59±0.48(Predicted)
form powder to crystal
color White to Light yellow to Light orange

SAFETY

Risk and Safety Statements

HS Code  2924.29.7790

OTAVA-BB 7070707015 price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10012682 CAY10585 ≥97% 934593-90-5 1mg $16 2024-03-01 Buy
Cayman Chemical 10012682 CAY10585 ≥97% 934593-90-5 5mg $63 2024-03-01 Buy
Cayman Chemical 10012682 CAY10585 ≥97% 934593-90-5 10mg $109 2024-03-01 Buy
Cayman Chemical 10012682 CAY10585 ≥97% 934593-90-5 25mg $235 2024-03-01 Buy
Tocris 6322 LW6 ≥98%(HPLC) 934593-90-5 10 $139 2021-12-16 Buy
Product number Packaging Price Buy
10012682 1mg $16 Buy
10012682 5mg $63 Buy
10012682 10mg $109 Buy
10012682 25mg $235 Buy
6322 10 $139 Buy

OTAVA-BB 7070707015 Chemical Properties,Uses,Production

Description

Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor composed of a HIF-1α subunit and HIF-1β subunit. Whereas the HIF-1β subunit is constitutively expressed, the HIF-1α subunit is regulated by cellular oxygen levels and therefore plays an important role in maintaining cellular oxygen homeostasis. Under normoxic conditions, HIF-1α is selectively hydroxylated on proline residues 402 and 577 and targeted for destruction by the ubiquitin-proteasome system. Under hypoxic conditions, HIF-1α accumulates and dimerizes with HIF-1β to promote the transcription of a number of genes involved in angiogenesis, glycolysis, growth factor signaling, tumor invasion, and metastasis. CAY10585 is a novel small molecule inhibitor of HIF-1α accumulation and gene transcriptional activity. In a gene reporter assay using human Hep3B and AGS cell lines, CAY10585 prevented HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 μM, respectively. It blocks HIF-1α accumulation in Hep3B cells in a concentration and time-dependent manner, with complete inhibition at a concentration of 30 μM within 12 hours. CAY10585 also significantly suppresses transcription of the HIF-1 target genes VEGF and erythropoietin at 10 μM.

Uses

CAY10585 is a class of hypoxia-inducible factor (HIF-1) responsible for radiation resistance and poor prognosis in cancer therapy.

storage

Store at -20°C

OTAVA-BB 7070707015 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 81)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32951 60
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29814 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32077 58
Shenzhen Shengda Pharma Limited 		755-85269922 +8613424394241 sales@shengdapharm.com CHINA 310 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38468 58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd 		+8618235132063 sales@tihondan.com China 3741 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58

View Lastest Price from OTAVA-BB 7070707015 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
LW6 pictures 2024-11-11 LW6
934593-90-5
 US $39.00-91.00 / mg 99.10% 10g TargetMol Chemicals Inc.
OTAVA-BB 7070707015 pictures 2019-12-24 OTAVA-BB 7070707015
934593-90-5
 US $1.00 / g 1g 99% 20kg Career Henan Chemical Co
  • LW6 pictures
  • LW6
    934593-90-5
  • US $39.00-91.00 / mg
  • 99.10%
  • TargetMol Chemicals Inc.
OTAVA-BB 7070707015 CAY10585 HIF-1α inhibitor LW6 LW8 4-Hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]aMino]-benzoic Acid Methyl Ester Hypoxia inducible factor-1α inhibitor CAY 10585;CAY-10585;CAY10585;LW6 LW 6 (This product is unavailable in the U.S.) methyl 3-(2-(4-((1r,3r,5r,7r)-adamantan-2-yl)phenoxy)acetamido)-4-hydroxybenzoate W6 Benzoic acid, 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]-, methyl ester Methyl 3-[[[4-(adamantan-1-yl)phenoxy]acetyl]amino]-4-hydroxybenzoate 3-[[[4-(Adamantan-1-yl)phenoxy]acetyl]amino]-4-hydroxybenzoic Acid Methyl Ester methyl 3-(2-(4-(adamantan-1-yl)phenoxy)acetamido)-4-hydroxybenzoate CAY10585，LW6 HIF-1α inhibitor LW 6,Apoptosis,LW-8,Hypoxia-inducible factors,inhibit,HIF-PH,HIF/HIF Prolyl-Hydroxylase,LW6,LW-6,HIFs,Inhibitor,LW 8 LW6(CAY10585) 934593-90-5 Aromatics, Inhibitors