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6-Aminonicotinamid

6-Aminopyridine-3-carboxamide Struktur
329-89-5
CAS-Nr.
329-89-5
Bezeichnung:
6-Aminonicotinamid
Englisch Name:
6-Aminopyridine-3-carboxamide
Synonyma:
6-AN;6-ANA;U-8774;fda0121;SR-4388;FDA 0121;nsc21206;NSC 21206;NSC-13128;BRN 2034522
CBNumber:
CB9224555
Summenformel:
C6H7N3O
Molgewicht:
137.14
MOL-Datei:
329-89-5.mol

6-Aminonicotinamid Eigenschaften

Schmelzpunkt:
245-248 °C (lit.)
Siedepunkt:
251.97°C (rough estimate)
Dichte
1.2620 (rough estimate)
Brechungsindex
1.6910 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
L?slichkeit
insoluble in H2O; insoluble in EtOH; ≥13.7 mg/mL in DMSO
Aggregatzustand
powder to crystal
pka
15.66±0.50(Predicted)
Farbe
White to Light yellow
Wasserl?slichkeit
Soluble in Dimethyl sulfoxide (DMSO). Insoluble in water.
BRN 
116042
CAS Datenbank
329-89-5(CAS DataBase Reference)
NIST chemische Informationen
Nicotinamide, 6-amino-(329-89-5)
EPA chemische Informationen
6-Aminonicotinamide (329-89-5)

Sicherheit

Kennzeichnung gef?hrlicher T
R-S?tze: 61
S-S?tze: 53-45
RIDADR  1655
WGK Germany  3
RTECS-Nr. US4550000
Hazard Note  Toxic
HazardClass  6.1
PackingGroup  II
HS Code  29333990

6-Aminonicotinamid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R61:Kann das Kind im Mutterleib sch?digen.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Verwenden

antineoplastic, apoptosis inducer

Definition

ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells.

Allgemeine Beschreibung

White crystalline solid.

Air & Water Reaktionen

Insoluble in water.

Reaktivit?t anzeigen

An amine and amide. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 6-Aminopyridine-3-carboxamide emits toxic fumes of NOx.

Brandgefahr

Flash point data for 6-Aminopyridine-3-carboxamide are not available; however, 6-Aminopyridine-3-carboxamide is probably combustible.

6-Aminonicotinamid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


6-Aminonicotinamid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 180)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Jusheng Technology Co.,Ltd.
18871490254
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CONIER CHEM AND PHARMA LIMITED
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ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23541 58
Hefei Hirisun Pharmatech Co., Ltd
+8615056975894
shawn@hirisunpharm.com CHINA 9911 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58

329-89-5(6-Aminonicotinamid)Verwandte Suche:


  • 6-azanylpyridine-3-carboxamide
  • Nicotinamide, 6-amino-
  • Nicotinamide, 6-amino- (8CI)
  • WLN: T6NJ BZ EVZ
  • 6-Aminonikotinsaeureamid [German]
  • 6-Aminonitoinamide
  • 2-Amino-5-carbamoylpyridine
  • 3-Pyridinecarboxamide, 6-amino-
  • 6-amino-3-pyridinecarboxamid
  • 6-amino-nicotinamid
  • 6-Aminonicotinic acid amide
  • 6-aminonicotinicacidamide
  • 6-Amino-nicotinsaeureamid
  • 6-Aminonikotinsaeureamid
  • 6-AN
  • 6-ANA
  • Aminonicotinamide
  • FDA 0121
  • fda0121
  • NSC 21206
  • nsc21206
  • U-8774
  • 2-AMINOPYRIDINE-5-CARBOXAMIDE
  • 6-AMINOPYRIDINE-3-CARBOXAMIDE
  • 6-AMINONICOTINAMIDE
  • 6-AMINO-3-PYRIDINECARBOXAMIDE
  • 6-Aminoincotinamide
  • 3-Pyridinecarboxamide,6-amino-(9CI)
  • NSC-13128
  • SR-4388
  • 6-Aminonicotinamide >
  • Antioxidant 40
  • BRN 2034522
  • 6-aminonicotinic amide
  • 6-Aminonicotinamide 95+%
  • Apremilast Impurity 126
  • 329-89-5
  • Heterocyclic Building Blocks
  • Pyridines
  • Building Blocks
  • C6
  • Heterocyclic Compounds
  • Building Blocks
  • C6
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • AMIDE
  • Pyridine series
  • Amines
  • Pyridines
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