Licofelone
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- CAS-Nr.
- 156897-06-2
- Englisch Name:
- Licofelone
- Synonyma:
- icofeL;ML 3000;Licofelone;Licofelone, >=99%;Licofelone, ML-3000;Licofelone USP/EP/BP;16-dihydrotanshinone I;2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid;1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl-;6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid
- CBNumber:
- CB91385206
- Summenformel:
- C23H22ClNO2
- Molgewicht:
- 379.88
- MOL-Datei:
- 156897-06-2.mol
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Licofelone Eigenschaften
- Schmelzpunkt:
- 162-163°C
- Siedepunkt:
- 539.7±50.0 °C(Predicted)
- Dichte
- 1.23
- storage temp.
- -20°C Freezer
- L?slichkeit
- Chloroform, Methanol
- pka
- 4.47±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Off-White to Light Yellow
- CAS Datenbank
- 156897-06-2(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Licofelone Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Cross-
talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-
1β (IL-
1β) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO) pathways, that decreases levels of prostaglandin E
2, leukotriene B
4, and lipoxins and prevents lipopolysaccharide-
stimulated IL-
1β expression. The IC
50 values for inhibition of human thrombocyte COX and human 5-
LO are 0.16 μM and 0.23 μM, respectively. Unlike other non-
steroidal anti-
inflammatory drugs, licofelone causes little or no damage to the gastric mucosa in rabbit parietal cells. This is presumably the result of licofelone’s affects on acid-
secretory mechanisms, mediated by the inhibition of 5-
LO activity.
Chemische Eigenschaften
Yellowish Solid
Licofelone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Licofelone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 122)Lieferanten
156897-06-2()Verwandte Suche:
- 2-[6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
- Licofelone, ML-3000
- [2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
- ML 3000
- 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid
- Licofelone
- 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl- 1H-pyrrolizine-5-acetic Acid
- 1H-Pyrrolizine-5-aceticacid, 6-(4-chlorophenyl)-2,3-dihydro-2,2-diMethyl-7-phenyl-
- Licofelone, >=99%
- icofeL
- Licofelone USP/EP/BP
- 16-dihydrotanshinone I
- 156897-06-2
- C23H22ClNO2
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Inhibitors
