Aldosteron
|
|
|
- CAS-Nr.
- 52-39-1
- Bezeichnung:
- Aldosteron
- Englisch Name:
- ALDOSTERONE
- Synonyma:
- Reichstein;LECTROCORTIN;REICHSTEIN X;μ100 97% (CP);ALD ELISA;NSC 73856;Aldocorten;Aldocortin
- CBNumber:
- CB8431679
- Summenformel:
- C21H28O5
- Molgewicht:
- 360.45
- MOL-Datei:
- 52-39-1.mol
|
Aldosteron Eigenschaften
- Schmelzpunkt:
- 170-172°C
- alpha
- D23 +152.2° (anhydr; c = 2 in acetone); D25 +161° (c = 0.1 in chloroform)
- Siedepunkt:
- 412.46°C (rough estimate)
- Dichte
- 1.28
- Brechungsindex
- 1.6120 (estimate)
- Flammpunkt:
- 2℃
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 12.98±0.10(Predicted)
- Aggregatzustand
- Crystalline Powder
- Farbe
- White
- Optische Aktivit?t
- +14523 (c 0.99, acetone)
- Wasserl?slichkeit
- 51.18mg/L(37 ºC)
- Merck
- 13,224
- BRN
- 3224996
- CAS Datenbank
- 52-39-1(CAS DataBase Reference)
- EPA chemische Informationen
- Aldosterone (52-39-1)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS02.jpg" width="20" height="20" /> |
P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
|
| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
|
Aldosteron Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Aldosterone is a mineralocorticosteroid that takes part in the regulation of electrolytic balance
in the organism. Aldosterone lowers excretion of sodium ions from the body, thus
increasing their reabsorption and increasing secretion of potassium ions in renal tubules.
Being a competitive antagonist of aldosterone, spironlactone blocks aldosterone receptors,
thus increasing excretion of sodium, chloride, and corresponding equivalents of water with
urine, thus retaining the amount of potassium ions in the organism. Spironolactone is used
both individually as well as in combination with thiazides, since it lowers kaliuresis caused
by thiazide diuretics.
Chemische Eigenschaften
White Solid
Verwenden
Labelled Aldosterone. Aldosterone is an adrenocortical steroid which exerts regulatory influence on metabolism of electrolytes and water. Biologically active aldosterone isomer; a mineralocorticoid pr
oduced by the adrenal cortex that induces urinary excretion of K+ and renal reabsorptioon of Na+. Exists as an equilibrium mixture of the aldehyde and the hemiacetal.
Definition
ChEBI: A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, i
creased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
Health Hazard
Aldosterone(Aldocortin; electrocortin; mineralocorticoid; 18-oxocorticosterone): (1)Maintenance of normal electrolyte blood balances;(2)Prolongs survival of adrenalectomized animals;(3)Accelerates gluconeogenesis;(4)Regulates kidney function.
l?uterung methode
Crystallise aldosterone from aqueous acetone. It exists in solution as an equilibrium mixture of free aldehyde and its cyclic hemiacetal, favouring the hemiacetal. The 21-acetate crystallises from Me2CO/Et2O or CH2Cl2/EtOAc and has m 198-199o, [] D +121.7o (c 0.7, CHCl3). [Barton et al. J Chem Soc Perkin Trans 1 2243 1975, Beilstein 8 IV 3491.]
Aldosteron Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Sodium triacetoxyborohydride
D-ALDOSTERONE 21-ACETATE
Pregn-4-en-18-oic acid, 11,21-dihydroxy-3,20-dioxo-, γ-lactone, (11β)- (9CI)
Pregn-4-en-18-oic acid, 21-(acetyloxy)-11-hydroxy-3,20-dioxo-, γ-lactone, (11β)- (9CI)
Pregn-5-en-18-oic acid, 3,3:20,20-bis[1,2-ethanediylbis(oxy)]-11,21-dihydroxy-, γ-lactone, (11β)- (9CI)
Downstream Produkte
Aldosteron Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 184)Lieferanten
- ELECTROCORTIN
- 11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al
- 11beta,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al
- 18-Oxocorticosterone
- 21-dihydroxy-3,20-dioxo-1(11-beta)-pregn-4-en-18-a
- 21-dihydroxy-3,20-dioxo-1(11beta)-pregn-4-en-18-a
- Aldocorten
- Aldocortene
- Aldocortin
- D-aldosterone
- Elektrocortin
- Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11beta)-
- 11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al
- 11β,21-Dihydroxypregn-4-ene-3,18,20-trione
- 11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
- ALDOSTERONE(RG)
- ALD ELISA
- Aldosterone-D5
- (11)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al
- 18-Formyl-11,21-dihydroxy-4-pregnene-3,20-dione
- NSC 73856
- (11)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al-d5
- 11,21-Dihydroxypregn-4-ene-3,18,20-trione-d5
- 18-Formyl-11,21-dihydroxy-4-pregnene-3,20-dione-d5
- 18-Oxocorticosterone-d5
- Aldocortene-d5
- Electrocortin-d5
- Elektrocortin-d5
- Aldosterone solution
- aldosterone solution,100ppm
- 4-PREGNEN-11-BETA, 21-DIOL-3,18,20-TRIONE
- 4-PREGNEN-11-BETA,21-DIOL-3,20-DIONE 18-AL
- 4-PREGNEN-18-AL-11B,21-DIOL-3,20-DIONE
- 4-PREGNEN-18-AL-11-BETA,21-DIOL-3,20-DIONE
- ALDOSTERONE
- 11BETA,21-DIHYDROXYPREGN-4-ENE-3,18,20-TRIONE
- 11-BETA,18-EPOXY-18,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
- 11BETA,21-DIHYDROXY-3,20-DIOXO-4-PREGNEN-18-AL
- 11B-21-DIHYDROXY-3,20-DIOXO-4-PREGNAN-18-AL
- (11BETA)-11,21-DIHYDROXY-3,20-DIOXO-PREGN-4-EN-18-AL
- 18-ALDOCORTICOSTERONE
- 18-KETOCORTICOSTERONE
- NSC 73856-d5
- 11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al
- 11beta,21-Dihydroxy-3,20-diketopregn-4-ene-18-al
- (1R,2S,5S,6S,14R,15S,16S)-18-hydroxy-2-(2-hydroxyacetyl)-14-Methyl-17-oxapentacyclo[14.2.1.0^{1,5}.0^{6,15}.0^{9,14}]nonadec-9-en-11-one
- (11β)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al-d4
- 11β,21-Dihydroxypregn-4-ene-3,18,20-trione-d4
- 18-ForMyl-11β,21-dihydroxy
-4-pregnene-3,20-dione-d4
- 18-Oxocorticosterone-d4
- Aldocortene-d4
- Aldosterone-d4
- Electrocortin-d4
- Elektrocortin-d4
- 11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al, 11β,21-Dihydroxypregn-4-ene-3,18,20-trione, 18-Aldocorticosterone, Reichstein X
- Aldosterone,98%
- Aldosterone,11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al, 11β,21-Dihydroxypregn-4-ene-3,18,20-trione, 18-Aldocorticosterone, Reichstein X
- Aldosterone-[2,2,4,6,6,17,21,21-2H7]
