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52-39-1

中文名稱 醛固酮
英文名稱 ALDOSTERONE
CAS 52-39-1
EINECS 編號(hào) 200-139-9
分子式 C21H28O5
MDL 編號(hào) MFCD00051136
分子量 360.44
MOL 文件 52-39-1.mol
更新日期 2024/12/17 09:24:29
52-39-1 結(jié)構(gòu)式 52-39-1 結(jié)構(gòu)式

基本信息

中文別名
醛固酮
醛固醇酮
醛甾酮
英文別名
11B-21-DIHYDROXY-3,20-DIOXO-4-PREGNAN-18-AL
(11BETA)-11,21-DIHYDROXY-3,20-DIOXO-PREGN-4-EN-18-AL
11-BETA,18-EPOXY-18,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
11BETA,21-DIHYDROXY-3,20-DIOXO-4-PREGNEN-18-AL
11BETA,21-DIHYDROXYPREGN-4-ENE-3,18,20-TRIONE
18-ALDOCORTICOSTERONE
18-KETOCORTICOSTERONE
4-PREGNEN-11-BETA, 21-DIOL-3,18,20-TRIONE
4-PREGNEN-11-BETA,21-DIOL-3,20-DIONE 18-AL
4-PREGNEN-18-AL-11B,21-DIOL-3,20-DIONE
4-PREGNEN-18-AL-11-BETA,21-DIOL-3,20-DIONE
ALDOSTERONE
ELECTROCORTIN
LECTROCORTIN
REICHSTEIN X
11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al
11beta,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al
18-Oxocorticosterone
21-dihydroxy-3,20-dioxo-1(11-beta)-pregn-4-en-18-a
21-dihydroxy-3,20-dioxo-1(11beta)-pregn-4-en-18-a

物理化學(xué)性質(zhì)

外觀性質(zhì)醛甾酮屬一種類固醇(steroid)激素,為人體鹽水平衡調(diào)節(jié)劑(一種礦物類皮質(zhì)激素,主要由腎上腺皮質(zhì)球狀帶分泌。此外,心臟、腦、血管壁也能合成和分泌醛甾酮。微溶于水,溶于乙醇、醚和氯仿。[a]20/D:155° (c=0.1, CHCl3)
熔點(diǎn)170-172°C
比旋光度D23 +152.2° (anhydr; c = 2 in acetone); D25 +161° (c = 0.1 in chloroform)
沸點(diǎn)412.46°C (rough estimate)
密度1.28
折射率1.6120 (estimate)
閃點(diǎn)2℃
儲(chǔ)存條件2-8°C
溶解度可溶于丙酮(輕微)、氯仿(輕微)、DMSO(輕微)、甲醇(輕微)
酸度系數(shù)(pKa)12.98±0.10(Predicted)
形態(tài)結(jié)晶粉末
顏色白色
水溶解性51.18mg/L(37 ºC)
Merck13,224
BRN3224996
CAS 數(shù)據(jù)庫(kù)52-39-1(CAS DataBase Reference)
EPA化學(xué)物質(zhì)信息Aldosterone (52-39-1)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
警示詞危險(xiǎn)
危險(xiǎn)性描述H225-H302+H312+H332-H319
防范說(shuō)明P210-P280-P305+P351+P338
危險(xiǎn)品標(biāo)志Xi,Xn,F
危險(xiǎn)類別碼36/37/38-36-20/21/22-11
安全說(shuō)明S22-S24/25
危險(xiǎn)品運(yùn)輸編號(hào)UN 1648 3 / PGII
WGK Germany3
RTECS號(hào)TU4523000
海關(guān)編碼29372900

應(yīng)用領(lǐng)域

用途一
誘導(dǎo)尿排泄鉀離子K+,同時(shí)使腎臟吸收鈉離子Na+。

52-39-1(安全特性,毒性,儲(chǔ)運(yùn))

儲(chǔ)運(yùn)特性
庫(kù)房通風(fēng)低溫干燥; 與食品添加劑分開(kāi)存放
可燃性危險(xiǎn)特性
易燃; 燃燒排放刺激煙霧
類別
有毒物品
滅火劑
泡沫,沙土,二氧化碳,干粉, 霧狀水

知名試劑公司產(chǎn)品信息

常見(jiàn)問(wèn)題列表

生物活性
Aldosterone 是原發(fā)性鹽皮質(zhì)激素。Aldosterone 是一種類固醇激素,通過(guò)腎上腺皮質(zhì)的腎小球區(qū) (ZG) 對(duì)腎素-血管緊張素系統(tǒng)激活 (RAS) 或高鉀飲食反應(yīng)而合成和分泌。Aldosterone 活性在細(xì)胞水平上依賴于胞漿/核鹽皮質(zhì)激素受體 (MR) 的結(jié)合和激活。
靶點(diǎn)

Human Endogenous Metabolite

體外研究

Aldosterone (1-1000 nM; 24 hours) inhibits interleukin-1β-stimulated nitrite production by vascular smooth muscle cells in a dose-dependent manner.

體內(nèi)研究

Aldosterone (1 mg/Kg+1% NaCl; i.h.; once daily for 3 weeks) significantly increases systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP).
Aldosterone (0.72 mg/kg/day; 14 days) causes a small increase ( 14 mmHg) in blood pressure in male mice.

Animal Model: Forty male Wistar rats
Dosage: 1 mg/Kg (+1% NaCl)
Administration: i.h.; once daily for 3 weeks
Result: Systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were significantly higher in aldosterone-salt-treated animals.
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