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Alvespimycin

Alvespimycin Struktur
467214-20-6
CAS-Nr.
467214-20-6
Englisch Name:
Alvespimycin
Synonyma:
17-DMAG;17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin;17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin;DMAG-d6;CS-2382;17-DMAG-d6;spiromycin;17-DMAG HCI;Alvespimycin;NSC 707545-d6
CBNumber:
CB7972636
Summenformel:
C32H48N4O8
Molgewicht:
616.75
MOL-Datei:
467214-20-6.mol

Alvespimycin Eigenschaften

Schmelzpunkt:
>270°C (dec.)
Siedepunkt:
810.5±65.0 °C(Predicted)
Dichte
1.20
storage temp. 
Desiccate at -20°C
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
8.48±0.70(Predicted)
Farbe
Very Dark Purple
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  29419090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Alvespimycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Geldanamycin is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 = 24 nM) and has excellent bioavailability and tissue distribution in animals. Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer. This compound also suppresses inflammation by interfering with signaling through the NF-κB pathway. 17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes.

Chemische Eigenschaften

Solid

Verwenden

17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.

Definition

ChEBI: A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group.

Biologische Aktivit?t

Water-soluble analog of 17-AAG (17-Demethoxy-17-(2-propenylamino)geldanamycin ) and geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI 50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).

Alvespimycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Alvespimycin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 113)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Haibo Biotechnology Co., Ltd
+undefined18602966907
qinhe02@xaltbio.com China 997 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29884 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32118 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616
gksales1@gk-bio.com China 9315 58
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19741 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471
sales@sarms4muscle.com China 10473 58

467214-20-6()Verwandte Suche:


  • 17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXYG
  • 17-DMAGhydrochloride
  • Alvespimycin
  • 17-DMAG (Alvespimycin)
  • Unii-001L2fe0m3
  • 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycinhydrochloride
  • 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin
  • 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin-d6
  • 17-[2-(DiMethylaMino)ethylaMino]-17-desMethylgeldanaMycin Hydrochloride
  • 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxy GeldanaMycin Hydrochloride
  • 17-N-(2-DiMethylaMinoethylaMino)-17-deMethoxygeldanaMycin Hydrochloride
  • DMAG Hydrochloride
  • NSC 707545 Hydrochloride
  • 17-[2-[(DiMethyl-d6)aMino]ethylaMino]-17-desMethylgeldanaMycin
  • 17-DeMethoxy-17-[[2-[(diMethyl-d6)aMino]ethyl]aMino]geldanaMycin
  • 17-DMAG-d6
  • 17-N-[(diMethyl-d6)aMinoethylaMino]-17-deMethoxygeldanaMycin
  • AlvespiMycin-d6
  • DMAG-d6
  • NSC 707545-d6
  • AlvespiMycin freebase
  • In-house Standard
  • 17DMAG (17-diMethylaMinoethylaMino-17-deMethoxy-geldanaMycin)
  • AlvespiMycin(17-DMAG)
  • 17-DMAG/ Alvespimycin/ 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin
  • (150270-08-9) alvespimycin
  • CS-2382
  • 17-DMAG;KOS-1022;NSC-707545
  • Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-
  • 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin
  • 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin
  • 17-DMAG
  • 17-DMAG HCI
  • spiromycin
  • 467214-20-6
  • C32H48N4O8HCl
  • Isotope Labelled Compounds
  • Amines
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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