Deferasirox
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- CAS-Nr.
- 201530-41-8
- Englisch Name:
- Deferasirox
- Synonyma:
- 20kg;Exjade;4-[3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,4-triazolidin-1-yl]benzoic acid;ICL-670;Delarox;Delalox;CGP-72670;eferasirox;deferasirox;Deferisirox
- CBNumber:
- CB7855359
- Summenformel:
- C21H15N3O4
- Molgewicht:
- 373.36
- MOL-Datei:
- 201530-41-8.mol
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Deferasirox Eigenschaften
- Schmelzpunkt:
- 260-2620C
- Siedepunkt:
- 672.1±65.0 °C(Predicted)
- Dichte
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- L?slichkeit
- Soluble in DMSO (10 mg/ml)
- Aggregatzustand
- solid
- pka
- pKa1 4.57, pKa2 8.71, pKa3 10.56 (Nick); Also reported in H2O/DMSO (CDMSO = 0.20) as pKa1 4.61, pKa2 10.12, pKa3 12.08 (Steinhauser)
- Farbe
- Off-white to white
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P391 |
Verschüttete Mengen aufnehmen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Deferasirox Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Linagliptin was originally discovered at Boehringer Ingelheim as
an orally active dipeptidyl peptidase-IV (DPP-4) inhibitor. Eli Lilly
and Boehringer Ingelheim co-developed and launched linagliptin
for type II diabetes as an adjunct to diet and exercise for the
improvement of adult glycemic control. Linagliptin has a superior
DPP-4 IC50 value of 1 nM, compared with 19 nM for sitagliptin,
24 nM for alogliptin, 50 nM for saxagliptin and 62 nM for vildagliptin. In addition, linagliptin exhibited prolonged pharmacodynamic
activity with long-lasting DPP-4 inhibition in several
preclinical species. Linagliptin showed good efficacy in phase II
clinical trials with doses as low as 5 mg and no signs of hypoglycemia
with doses as high as 600 mg. The prolonged pharmacological
effect of DPP-4 activity and the good safety/tolerability profile
provided the basis for linagliptin’s approval.
Chemische Eigenschaften
White to Off-White Solid
Verwenden
Biological Activity Chemical Information Tech Support & FAQs
Biological Activity
Deferasirox(Exjade) is a rationally-designed oral iron chelator. Its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions
Definition
ChEBI: A member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patient
receiving long-term blood transfusions.
Deferasirox Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Deferasirox Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 416)Lieferanten
201530-41-8()Verwandte Suche:
- Deferasirox(CGP-72670)
- Deferasirox(Exjade)
- 4-[3,5-bis(2-hydroxyphenyl)
- Deferasirox, >=99%
- Deferasirox D8
- 4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid
- deferasirox
- Deferasirox for research
- 4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic Acid
- CGP-72670
- ICL-670
- Benzoic acid, 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-
- Deferasirox D8Q: What is
Deferasirox D8 Q: What is the CAS Number of
Deferasirox D8 Q: What is the storage condition of
Deferasirox D8 Q: What are the applications of
Deferasirox D8
- Deferasirox for system suitability (Y0002197)Q: What is
Deferasirox for system suitability (Y0002197) Q: What is the CAS Number of
Deferasirox for system suitability (Y0002197)
- DeferasiroxQ: What is
Deferasirox Q: What is the CAS Number of
Deferasirox Q: What is the storage condition of
Deferasirox Q: What are the applications of
Deferasirox
- 4-[3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,4-triazolidin-1-yl]benzoicaChemicalbookcid
- Deferisirox
- Decitabine USP RC C
- [14C]Deferasirox
- [14C]4-[3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,4-triazolidin-1-yl]benzoic acid
- 4-[bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid
- Deferasirox USP/EP/BP
- Deferasirox (ICL 670)
- 4-[3,5-bis(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2,4-triazolidin-1-yl]benzoic acid
- 20kg
- Exjade
- Deferasirox Deferasirox（API)
- eferasirox
- Delarox
- Deferasirox (200 mg)
- Deferasirox IP/EP/INH
- Delalox
- 201530-41-8
- 530-41-8
- 140891-02-6
- C21H15N3O4
- Pharmaceutical intermediate
- Aromatics
- Chelating Agents & Ligands
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Exjade, ICL-670, ICL-670A, CGP-72670
- Chelating agent (iron)
- Aromatics Compounds
- 1
