Minoxidil
|
|
Minoxidil Eigenschaften
- Schmelzpunkt:
- 272-274 °C (dec.) (lit.)
- Siedepunkt:
- 348.61°C (rough estimate)
- Dichte
- 1.1651 (rough estimate)
- Brechungsindex
- 1.7610 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- Slightly soluble in water, soluble in methanol and in propylene glycol.
- pka
- 4.61(at 25℃)
- Aggregatzustand
- Solid
- Farbe
- White
- Wasserl?slichkeit
- Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol.
- Merck
- 14,6203
- BCS Class
- 3
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChIKey
- ZFMITUMMTDLWHR-UHFFFAOYSA-N
- CAS Datenbank
- 38304-91-5(CAS DataBase Reference)
- NIST chemische Informationen
- Minoxidil(38304-91-5)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xn,T+ | ||
---|---|---|---|
R-S?tze: | 22-36/37/38-26/27/28 | ||
S-S?tze: | 26-36-45-36/37/39-22 | ||
WGK Germany | 3 | ||
RTECS-Nr. | UV8200000 | ||
HS Code | 29335990 | ||
Giftige Stoffe Daten | 38304-91-5(Hazardous Substances Data) | ||
Toxizit?t | LD50 in rats, mice (mg/kg): 49, 51 i.v. (Carlson, Feenstra) |
Bildanzeige (GHS) | ||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alarmwort | Warnung | |||||||||||||||||||||||||||||||||||
Gefahrenhinweise |
|
|||||||||||||||||||||||||||||||||||
Sicherheit |
|
Minoxidil Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Beschreibung
Minoxidil is a peripheral vasodilator that directly relaxes vascular smooth musculature, thus, lowering systolic and diastolic pressure. Its action is linked to the activation of calcium channels. Open calcium channels cause hyperpolarization of smooth muscle cells, which in turn, reduces the flow of calcium ions into the cell, which is necessary for supporting vascular tonicity. However, when taking minoxidil, tachycardia, elevated renin secretion, and water and sodium ion retention all appear simultaneously with hypotension.Chemische Eigenschaften
White Crystalline SolidVerwenden
Used as an antihypertensive and antialopecia agent. Minoxidil activates ATP-activated K+ channelsDefinition
ChEBI: Minoxidil is a pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6. It has a role as a vasodilator agent and an antihypertensive agent. It is a pyrimidine N-oxide, a member of piperidines and an aminopyrimidine.Allgemeine Beschreibung
Minoxidil, 2,4-diamino-6-piperidinopyrimidine-3-oxide . It is converted to minoxidil sulfate in the liver bya sulfotransferase enzyme.The antihypertensive properties of minoxidil are similarto those of hydralazine hydrochloride, in that minoxidil candecrease arteriolar vascular resistance. Minoxidil exerts itsvasodilatory action by a direct effect on arteriolar smoothmuscle and appears to have no effect on the CNS or on theadrenergic nervous system in animals. The serum half-lifeis 4.5 hours, and the antihypertensive effect may last up to24 hours.
Biologische Aktivit?t
Antihypertensive. Antialopecia agent. K + channel (K ATP ) activator.Pharmakokinetik
Minoxidil is absorbed from the GI tract and is metabolized to its active sulfate metabolite. Plasma concentrations for minoxidil sulfate peak within 1 hour and then decline rapidly. Following an oral dose of minoxidil, its hypotensive effect begins in 30 minutes, is maximal in 2 to 8 hours, and persists for approximately 2 to 5 days. The delayed onset of the hypotensive effect for minoxidil is attributed to its metabolism to its active metabolite. The drug is not bound to plasma proteins. The major metabolite for minoxidil is its N-O-glucuronide, which unlike the sulfate metabolite is inactive as a hypotensive agent. Approximately 10 to 20% of an oral dose of minoxidil is metabolized to its active metabolite, minoxidil O-sulfate, and approximately 20% of minoxidil is excreted unchanged.Clinical Use
Minoxidil is used for severe hypertension that is difficultto control with other antihypertensive agents. The drug hassome of the characteristic side effects of direct vasodilatorydrugs. It causes sodium and water retention and may requirecoadministration of a diuretic. Minoxidil also causes reflextachycardia, which can be controlled by use of a -adrenergicblocking agent.Minoxidil topical solution is used to treat alopecia androgenitica(male-pattern baldness). Although the mechanismis not clearly understood, topical minoxidil is believed to increasecutaneous blood flow, which may stimulate hairgrowth. The stimulation of hair growth is attributed to vasodilationin the vicinity of application of the drug, resultingin better nourishment of the local hair follicles.
Nebenwirkungen
Adverse reactions include local irritation and contact dermatitis. If the treatment is discontinued, clinical regression occurs within 3 months to the state of hair thinning that would have occurred had the treatment not been started. Twice-daily treatment is more efficacious than once-daily application. Women who use the5%concentrationmay note the development of facial hair, which is reversible on discontinuation of the medication. The 5% concentration can be more irritating than the 2% solution.Arzneimittelwechselwirkung
When minoxidil is administered with diuretics or other hypotensive drugs, the hypotensive effect of minoxidil increases, and concurrent use may cause profound orthostatic hypotensive effects.Minoxidil Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Pyridin-2,6-diyldiamin
Perbenzoesure
Piperidin
4-Chloropyrimidine
Methylcyanacetat
Ammoniak, wasserfrei
2,4,6-Trichlorpyrimidin
Phosphorus oxychloride
3-Chlorperbenzoesure
Barbitursure
Downstream Produkte
Minoxidil Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 776)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Beri Pharma Co., Ltd. | +8613417710166 |
sales@zhberi.com | China | 227 | 58 |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 1169 | 58 |
Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9312 | 58 |
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 |
sales06@tgybio.com | China | 901 | 58 |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 988 | 58 |
Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 |
evan@tyvovo.com | China | 148 | 58 |
Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 |
info@hyper-chem.com | China | 295 | 58 |
HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 +86-18532138899 |
L18532138899@163.com | China | 939 | 58 |
Shaanxi Xianhe Biotech Co., Ltd | +8617709210191 |
Jerry@xhobio.com | China | 882 | 58 |
Hebei Weibang Biotechnology Co., Ltd | +8615531157085 |
abby@weibangbio.com | China | 8810 | 58 |
38304-91-5(Minoxidil)Verwandte Suche:
Zinkoxid
Eisenoxid
Pyrimidin
Stickstoffmonoxid
Ethylenoxid
Magnetit
2,2,6,6-Tetramethyl-4-piperidylamin
Magnesiumoxid
gamma-(4-(p-Chlorphenyl)4-hydroxy-piperidino)-p-fluorbutyrophenon
Rutil (TiO2)
(Diethoxymethyl)diphenylphosphine oxide
Distickstoffoxid
PYRIMITHAMINE
4-Chlor-2,6-diaminopyrimidin
Triclosan
Minoxidil
- 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine
- 6-piperidino-2,4-diaminopyrimidine3-oxide
- alopexil
- alostil
- lonolox
- minossidile
- minoximen
- prexidil
- regaine
- tricoxidil
- 2,6-diaMino-4-(piperidin-1-yl)-1$l^{5},3-pyriMidin-1-one
- Minoxidil (U-10858)
- Minoxidil/2,4-DiaMino-6-piperidino-pyriMidine-3-oxide
- 2,6-Diamino-4-(piperidin-1-yl)pyrimidine 1-oxide
- 2,3-dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine
- 2,4-diamino-6-piperidinilpirimidina-3-ossido
- [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
- ANTI-PDP1 (CENTER) antibody produced in rabbit
- PPM2C
- Minoxidil, Loniten,Lonolox,Lonoten,Minona
- inoxidil
- regain
- MONOXIDIL
- MINOXIDIL
- U-10858
- 2,4-DIAMINO-6-PIPERIDINOPYRIMIDINE 3-OXIDE
- 6-(1-PIPERIDINYL)-2,4-PYRIMIDINEDIAMINE 3-OXIDE
- 6-(1-PIPERIDINYL)PYRIMIDINE-2,4-DIAMINE 3-OXIDE
- loniten
- Minoidil
- MINOXIDIL EP, BP, USP
- MINOXIDIL K+ CHANNEL ACTIVATOR,
- MethylPhosphateEster
- 2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide
- MINOXIDIL,POWDER,USP
- TRICLOSAN (IRGASAN)
- Minoxidil (Subject To Patent Free)
- 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
- Minoxidil,6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide
- Minoxidil (125 mg)
- Aalopexil
- 2,4-diamino-6-piperidino-pyrimidin3-oxide
- 2,6-diamino-4-(piperidin-1-yl)pyrimidin-1-ium-1-olate
- Minoxidil, 98%, vasodilator agent
- LONTEN
- Minoxidil>
- Minoxidil powder/Minoxidil
- 6-(piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide
- Minoxidil Solution in Methanol, 100μg/mL
- minoxcidil
- 2,6-Diamino-4-piperidinopyrimidine 1-Oxide
- Minoxidil USP/EP/BP
- Minoxidil 5% solution
- Latilavir side chain
- Pure Minoxidil powder
- Sonwu CAS?38304-91-5?of Minoxidil Powder
- MINOⅪDIL
- Pharmaceutical Minoxidil