Amisulpride
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- CAS-Nr.
- 71675-85-9
- Englisch Name:
- Amisulpride
- Synonyma:
- 4-amino-n-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzam;4-amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide;SOCIAN;SOLIAN;AmisuL;Sulamid;DENIBAN;DAN-2163;Amisulprid;AMISULPRIDE
- CBNumber:
- CB7312326
- Summenformel:
- C17H27N3O4S
- Molgewicht:
- 369.48
- MOL-Datei:
- 71675-85-9.mol
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Amisulpride Eigenschaften
- Schmelzpunkt:
- 124-128
- Siedepunkt:
- 558.9±50.0 °C(Predicted)
- Dichte
- 1.200±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥5 mg/mL
- Aggregatzustand
- solid
- pka
- 13.73±0.46(Predicted)
- Farbe
- white
- Merck
- 14,485
- InChI
- InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21)
- InChIKey
- NTJOBXMMWNYJFB-UHFFFAOYSA-N
- SMILES
- C(NCC1CCCN1CC)(=O)C1=CC(S(CC)(=O)=O)=C(N)C=C1OC
- CAS Datenbank
- 71675-85-9(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| S-S?tze: |
22-24/25 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
CV2308701 |
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| HS Code |
2933.99.8290 |
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| Toxizit?t |
LD50 in male mice (mg/kg): 56-60 i.v.; 175-180 i.p.; 224-250 s.c.; 1024-1054 orally (Thominet) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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Amisulpride Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Amisulpride i s a n antipsychotic agent structurally related to sulpiride and sultopride. Useful in the treatment of schizophrenia, it is not, however, without EPS liability.
Chemische Eigenschaften
Off-White Solid
Verwenden
Amisulpride is a neuroleptic agent, an analogue of Sulpiride (S689145). Amisulpride is used as an antipsychotic. Amisulpride is a dopamine receptor antagonist.
Biologische Aktivit?t
Potent, selective dopamine D 2 and D 3 receptor antagonist. K i values are 2.8 and 3.2 nM respectively for human D 2 and D 3 and > 1000 nM for human D 1 , D 4 and D 5 receptors. Shows selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D 2 /D 3 receptors at higher doses. Preferentially interacts with limbic D 2 -like receptors in vivo . Atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.
Amisulpride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Amisulpride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 576)Lieferanten
71675-85-9()Verwandte Suche:
- benzamide,4-amino-n-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-metho
- Sulamid
- DAN-2163, Deniban, 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide
- Benzamide, 4-amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxy-
- 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-benzamide
- 4-aMino-5-(ethanesulfonyl)-N-{[(2S)-1-ethylpyrrolidin-2-yl]Methyl}-2-MethoxybenzaMide
- AMisulpride(DAN 2163)
- Amisulpride for system suitability
- AMISULPRIDE (OTHER HETERDCYCLIC CMPNDS W ITH NITROGEN HETRO ATOM (S) ONLY) (GROUP :B,SL NO:1135
- 4-AMINO-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-5-(ETHYLSULFONYL)-2-METHOXYBENZAMIDE
- AMISULPRIDE
- AMINOSULTOPRIDE
- DAN-2163
- DENIBAN
- SOCIAN
- SOLIAN
- Amisulpride, 1000ppm
- Amisulpride CRS
- Amisulpride for system suitability CRS
- Amoxicillin trihydrate CRS
- Amisulpride >
- AmisuL
- Amisulpride USP/EP/BP
- Amisulprid
- Amisulpride for system suitability (Y0001534)Q: What is
Amisulpride for system suitability (Y0001534) Q: What is the CAS Number of
Amisulpride for system suitability (Y0001534)
- AmisulprideQ: What is
Amisulpride Q: What is the CAS Number of
Amisulpride Q: What is the storage condition of
Amisulpride Q: What are the applications of
Amisulpride
- 4-amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide
- 4-amino-n-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzam
- Amisupiride
- h . 2-c h loro-N,N-d i e th yle th a na mi ne (2-c h lorotri e th yla mi ne , (2-c h loroe th yl)d i e th yla mi ne ).
- AMISULPRIDE IP/EP/BP
- Amisulpride BP/IP
- (±)-Amisulpride in acetonitrile
- (±)-Amisulpride in methanol
- 71675-85-9
- C17H27N3O4S
- DENIBAN
- Dopamine receptor
- Active Pharmaceutical Ingredients
- Antipsychotic
- Drug Analogues
- Intermediates & Fine Chemicals
- Pharmaceuticals
