2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
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- CAS-Nr.
- 1240948-72-4
- Englisch Name:
- 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
- Synonyma:
- Vonoprazan-3;Vonoprazan-024;TAK438 Impurity 32;Vonolazan impurity 3;Vonoprazan Impurity Ⅶ;Vonoprazan Impurity 33;TAK438 Intermediate 3;Vonoprazan Fumarate impurity G;Voronozan initiator 1 impurity I;2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
- CBNumber:
- CB72722688
- Summenformel:
- C11H6ClFN2
- Molgewicht:
- 220.63
- MOL-Datei:
- 1240948-72-4.mol
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2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Eigenschaften
- Siedepunkt:
- 403.0±45.0 °C(Predicted)
- Dichte
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 12.88±0.50(Predicted)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is an important pharmaceutical intermediate. It can be used in the preparation of vorexanol fumarate and vonoprazan, and can also be used as a chemical raw material for the synthesis of other organic compounds.
Verwenden
2-Chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile (Vonoprazan Impurity 33) is an impurity of Vonoprazan, a potassium-competitive acid blocker (P-CAB) that suppresses gastric acid secretion.
Synthese
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is synthesised using 2-[2-(2-fluorophenyl)-2-oxoethyl]malononitrile as raw material by chemical reaction. The specific synthesis steps are as follows:
2 g of the intermediate III-1 was dissolved in 40 ml of a solution of hydrochloric acid in ethyl acetate, and the mixture was stirred at room temperature overnight. After the reaction is completed, the solvent is distilled off under reduced pressure to give the compound of 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile, 2.1 g of a white solid with a yield of 96%.
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 135)Lieferanten
1240948-72-4()Verwandte Suche:
- 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
- 1H-Pyrrole-3-carbonitrile,2-chloro-5-(2-fluorophenyl)-
- Vonoprazan Fumarate impurity G
- Vonoprazan Impurity 33
- Vonoprazan Impurity Ⅶ
- Vonoprazan-024
- TAK438 Impurity 32
- Vonoprazan impurity 28/2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
- Vonoprazan impurity SM2-A: 2-chloro-5- (2-fluorophenyl) -1H-pyrrole-3-carbonitrile
- Vonoprazan-3
- Voronozan initiator 1 impurity I
- 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile (Vonoprazan Impurity）
- TAK438 Intermediate 3
- Vonolazan impurity 3
- 1240948-72-4
- 1240948-72-4
