Methylhydrogenfumarat
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Methylhydrogenfumarat Eigenschaften
- Schmelzpunkt:
- 144-145 °C (lit.)
- Siedepunkt:
- 250.0±23.0 °C(Predicted)
- Dichte
- 1.37 g/cm3
- storage temp.
- 2-8°C
- L?slichkeit
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 3.40±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Off-White
- maximale Wellenl?nge (λmax)
- 209nm(MeOH)(lit.)
- CAS Datenbank
- 2756-87-8(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
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Methylhydrogenfumarat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R41:Gefahr ernster Augensch?den.S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S39:Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Monomethyl fumarate (MMF), a bioactive metabolite of fumaric acid ester, is an immunotherapy for psoriasis that causes decreased production of Th1 cytokines and lymphocytopenia. Monomethyl fumarate was shown to decrease DC response to LPS and decreased IL-12p70 and IL-10 production.Chemische Eigenschaften
Off-White SolidVerwenden
Monomethyl fumarate is used to treat the relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. This medicine will not cure MS, but it may slow some of the disabling effects and decrease the number of relapses of the disease.Fumaric Acid Monomethyl Ester is one of the most bioactive anti-psoriatic fumaric acid ester metabolite. Fumaric Acid Monomethyl Ester is potent nicotinic acid receptor agonist. Fumaric Acid Monomethy l Ester has also been shown to selectively stimulate of T helper 2 cytokine response.
synthetische
Monomethyl fumarate was synthesized by maleic anhydride and methanol. monomethyl fumarate could inhibit the growth of mold, and the storage time of feed could be prolonged.Definition
ChEBI: Monomethyl fumarate is a dicarboxylic acid monoester resulting from the formal condensation of one of the carboxy groups of fumaric acid with methanol. Is is a metabolite of dimethyl fumarate and used for the the treatment of patients with relapsing multiple sclerosis (MS). It also induces the NFE2L2 (Nrf2) transcription factor by binding to KEAP1. It has a role as an immunomodulator, an antioxidant and a drug metabolite. It is an enoate ester, a methyl ester and a dicarboxylic acid monoester. It derives from a fumaric acid.Synthesis Reference(s)
The Journal of Organic Chemistry, 23, p. 1559, 1958 DOI: 10.1021/jo01104a608Methylhydrogenfumarat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Methylhydrogenfumarat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 344)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Hebei Yanxi Chemical Co., Ltd. | +8617531153977 |
allison@yan-xi.com | China | 5856 | 58 |
Hebei Weibang Biotechnology Co., Ltd | +8617732866630 |
bess@weibangbio.com | China | 18148 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 |
sales@capot.com | China | 29793 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32965 | 60 |
Zjartschem | +86-571 87238903 |
jocelynpan@zjarts.com | CHINA | 988 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22963 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49374 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29810 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32161 | 58 |
2756-87-8(Methylhydrogenfumarat)Verwandte Suche:
Dimethylfumarat
Diethylphthalat
Eisen(II)fumarat
Methylacrylat
Hydratase, Fumarat
4,9-Dihydro-4-(1-methylpiperidin-4-yliden)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-onfumarat
Methanol
Tris(trimethylsilyl)phosphat
Tiamulin fumarate
Quetiapine fumarate
Acetonitril
Fumarsure
Wasserstoff
Dimethylsuccinat
Ethylfumarat
Fumars?ure-diethylester
Methyl
Malons?uredinitril
- (E)-2-Butenedioic acid hydrogen 1-methyl ester
- Fumaric acid hydrogen 1-methyl ester
- Monomethyl trans-ethylene-1,2-dicarboxylate
- Monomethyl fumarate
- mono-Methyl fumarate,Fumaric acid monomethyl ester, Methyl hydrogen fumarate
- (2E)-4-Methoxy-4-oxobut-2-enoic acid
- (2E)-2-Butenedioic Acid 1-Methyl Ester
- (E)-2-Butenedioic Acid MonoMethyl Ester
- FuMaric Acid Methyl Ester
- Mono-Methyl fuMarate 97%
- But-2-enedioic acid monomethyl ester
- MONO-METHYL FUMARATE 97
- Fumaric acid monomethyl ester, Methyl hydrogen fumarate
- Monomethyl Fumarate Labeled 13C4
- Methylhydrogenfumarat
- mono-Methyl fumarate,Fuma
- 2(E)-Butenedioic acid 1-methyl ester
- MonomethylFumarate>
- 2-Butenedioic acid (2E)-, 1-methyl ester
- TAK438 Impurity 110
- Vonoprazan Impurity 110
- (E)-4-methoxy-4-oxobut-2-enoic acid[MMF
- (E)-4-methoxy-4-oxobut-2-enoic acid(98%)
- Methyl hydrogen fumarate
- Fumaric acid monomethyl ester
- 4-Methoxy-4-oxobut-2-enoic acid
- (E)-4-Methoxy-4-oxobut-2-enoic acid
- Dimethyl Fumarate Related Compound A
- Dimethyl Fumarate USP Related Compound A
- Tenofovir disoproxil Impurity 84
- Monomethyl fumarate, 10 mM in DMSO
- 2756-87-8
- HO2CCHCHCO2CH3