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2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide

2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide Struktur
290297-26-6
CAS-Nr.
290297-26-6
Englisch Name:
2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide
Synonyma:
Netupitant;Netupitan;CID6451149;CID-6451149;CID 6451149;Ro 67-31898;Ro 67-31898/000;Netupitant(CID-6451149);NETUPITANT (RO 67-31898);2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-meth...
CBNumber:
CB71483126
Summenformel:
C30H32F6N4O
Molgewicht:
578.59
MOL-Datei:
290297-26-6.mol

2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide Eigenschaften

Schmelzpunkt:
156.2-160.0 °C
Siedepunkt:
597.4±50.0 °C(Predicted)
Dichte
1.255
storage temp. 
2-8°C
L?slichkeit
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
7.89±0.38(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White
InChIKey
WAXQNWCZJDTGBU-UHFFFAOYSA-N
SMILES
C(N(C)C1=C(C2C=CC=CC=2C)C=C(N2CCN(C)CC2)N=C1)(=O)C(C1C=C(C(F)(F)F)C=C(C(F)(F)F)C=1)(C)C
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Netupitant, originally developed by Helsinn Healthcare and later licensed to Eisai, Inc., was approved in the USA in October 2014 for the treatment of chemotherapy-induced nausea and emesis. Akynzeo ® is a fixed-dose combination of the new drug netupitant and the previously-approved 5-HT3 antagonist palonosetron. While palonosetron obtained approval previously for treating nausea and emesis occurring within the first 24 hours (acute phase) after chemotherapy, netupitant provides a synergistic effect with palonosetron, assisting in prevention of nausea and emesis in later stages following chemotherapy (25–120 h after chemotherapy treatment). Several clinical trials showed that this combination of netupitant and palonosetron (Akynzeo ?), in comparison to treatment with palonosetron treatment alone, led to an improved percentage of patients in all phases who did not experience any nausea and emesis after undergoing chemotherapy. Netupitant itself joins the class of selective Neurokinin- 1 (NK1) receptor antagonists which, in addition to their use for treating chemotherapy-induced nausea and emesis, also play an important role as therapies for depression and anxiety.

Verwenden

Antiemetic.

Definition

ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoic acid with the secondary amino group of N-methyl-4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin 3-amine; an antiemetic used in combination with palonosetron hydrochloride (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.

2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

N-[4-iodo-6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-2,2-dimethyl-propionamide Benzeneacetamide, N-[6-chloro-4-(2-methylphenyl)-3-pyridinyl]-N,α,α-trimethyl-3,5-bis(trifluoromethyl)- 6-CHLORO-4-O-TOLYL-NICOTINAMIDE 6-CHLORO-4-O-TOLYL-NICOTINIC ACID N-(6-(4-Methylpiperazin-1-yl)pyridin-3-yl)pivalaMide 2-(3,5-bis-trifluoromethylphenyl)-2-methyl-propionyl chloride N-tert-butyl-6-chloro-4-(o-tolyl)nicotinamide 3-PYRIDINAMINE, N-METHYL-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- 2-(4-Methylpiperazin-1-yl)-5-nitropyridine Methyl (6-(4-Methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbaMate 3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- 2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid 2-Chlor-5-nitropyridin

Downstream Produkte

2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 195)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Aceschem Inc.
+1-817863-6948 +1-（817）863-6948
 sales@aceschem.com United States 19632 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325
 sales1@chuanghaibio.com China 5889 58
shandong perfect biotechnology co.ltd 		+86-53169958659 +86-13153181156
 sales@sdperfect.com China 294 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 +86-18600796368
 sales@sjar-tech.com China 456 58
Watson Biotechnology Co.,Ltd 		+86-18186686046 +86-18186686046
 sales01@watsonbiotech.cn China 5841 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21634 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32957 60
TianYuan Pharmaceutical CO.,LTD 		+86-755-23284190 13684996853
sales@tianpharm.com CHINA 304 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58

290297-26-6()Verwandte Suche:

  • 2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl]-N-methylisobutyramide
  • 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide
  • Ro 67-31898/000
  • 2-(3,5-bis(trifluoroMethyl)phenyl)-N,2- diMethyl-N-(6-(4-Methylpiperazin-1-yl)-4- o-tolylpyridin-3-yl)propanaMide
  • BenzeneacetaMide, N,a,a-triMethyl-N-[4-(2-Methylphenyl)-6-(4-Methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoroMethyl)-
  • 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-
  • Ro 67-31898
  • Netupitan
  • CID 6451149
  • CID6451149
  • CID-6451149
  • Netupitant(CID-6451149)
  • 2-[3,5-Bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-y
  • NETUPITANT (RO 67-31898)
  • Benzeneacetamide, N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-
  • 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-meth...
  • NetupitantQ: What is Netupitant Q: What is the CAS Number of Netupitant Q: What is the storage condition of Netupitant Q: What are the applications of Netupitant
  • Netupitant
  • 290297-26-6
  • 290297-36-6
  • C30H32F6N4O
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