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Celastrol

Celastrol Struktur
34157-83-0
CAS-Nr.
34157-83-0
Englisch Name:
Celastrol
Synonyma:
Tripterine;Celastro;TRIPTERIN;NSC70931;Celatrol;CELASTROL;Celasterol;Celastrol(P);CELASTROL(SH);Celastrol >
CBNumber:
CB7146431
Summenformel:
C29H38O4
Molgewicht:
450.61
MOL-Datei:
34157-83-0.mol

Celastrol Eigenschaften

Schmelzpunkt:
219-230°C
Siedepunkt:
645.7±55.0 °C(Predicted)
Dichte
1.2
storage temp. 
-20°C
L?slichkeit
DMSO: >10mg/mL
pka
4.78±0.70(Predicted)
Aggregatzustand
solid
Farbe
red
maximale Wellenl?nge (λmax)
424nm(MeOH)(lit.)
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey
KQJSQWZMSAGSHN-JJWQIEBTSA-N
LogP
7.080 (est)
CAS Datenbank
34157-83-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 25
S-S?tze: 45-24/25
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  2
RTECS-Nr. YJ7900000
HS Code  29189900
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

Celastrol Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Orange Red Solid

Verwenden

Celastrol is an antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies. Celastrol also has been shown to have the power to kill tumor cells and can work as an anticarcinogen. It is also a leptin sensitizer with the potential to reduce weight in obesity.

Verwenden

An antioxidant natural product Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be

Definition

ChEBI: A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. otently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).

Allgemeine Beschreibung

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biologische Aktivit?t

Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF- α -induced NF κ B activation. Also shown to inhibit topoisomerase II activity in vitro (IC 50 = 7.41 μ M).

Celastrol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Celastrol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 406)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083
scglp@glp-china.com CHINA 1824 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-81138252 +86-18789408387
1057@dideu.com China 3959 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Chongqing Zhihe Biopharmaceutical Co., Ltd.
+86-18580541567; +8618580541567
sales@zhswyy.com China 301 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20284 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 3002 58
Hebei Shengyang Water Conservancy Engineering Co., Ltd.
+8615373025980
clara@hbshengyang.com China 875 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
+8615350851019
admin@86-ss.com China 1001 58
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9087 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60

34157-83-0()Verwandte Suche:


  • (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacid
  • Celastrol ,98%
  • (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
  • 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid
  • 3-Hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
  • Celastrol(Tripterine)
  • NSC70931
  • (2r,4as,6as,6ar,14as,14br)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid
  • 3-HYDROXY-9BETA,13ALPHA-DIMETHYL-2-OXO-24,25,26-TRINOROLEANA-1(10),3,5,7-TETRAEN-29-OIC ACID
  • 3-HYDROXY-24-NOR-2-OXO-1(10),3,5,7-FRIEDELATETRAEN-29-OIC ACID
  • 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oicacid, 3-hydroxy-9,13-dimethyl-2-oxo-, (9β,13α,14β,20α)-
  • (9,13a,14,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic Acid
  • 3-Hydroxy-2-oxo- 24-nor-D:A-friedooleana-1(10),3,5,7-tetraen-29-oic Acid
  • CELASTROL(SH)
  • CELASTROL
  • Celastrol (Tripterin)
  • CELASTROL(P)(PLEASE CALL)
  • (20R)-3-Hydroxy-2-oxo-24-nor-D:A-friedoolean-1(10),3,5,7-tetren-29-oic acid
  • 2-Oxo-3-hydroxy-24-norfriedela-1(10),3,5,7-tetraene-29-oic acid
  • 2-Oxo-3-hydroxy-24-norfriedelane-1(10),3,5,7-tetraene-29-oic acid
  • Celasterol
  • Celastrol, 98%, Protease inbibitor
  • Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem
  • good price Celastrol 34157-83-0
  • Factory Provide Pure Natural 98% Celastrol Powder 34157-83-0
  • 10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid
  • Celastrol >
  • Celatrol
  • (2S,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
  • Celastrol USP/EP/BP
  • Celastrol (NSC 70931)
  • Celastrol tripterine estratto
  • (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid
  • 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid,3-hydroxy-9,13-dimethyl-2-oxo-, (9b,13a,14b,20a)-
  • TRIPTERIN
  • Tripterine
  • Celastro
  • (2r,4as,6as,6ar,14as,14br)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylicacid
  • (9,13a,14,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-
  • 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oicacid,3-hydroxy-9,13-dimethyl-2-oxo-,(9β,13α,14β,20α)-
  • Celastrol -RM
  • Celastrol(P)
  • 34157-83-0
  • C29H38O4
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • ProteasomeInhibitors
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  • Miscellaneous Natural Products
  • Inhibitors
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  • Steroids
  • 34157-83-0
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