Ellagsure
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Ellagsure Eigenschaften
- Schmelzpunkt:
- ≥350 °C
- Siedepunkt:
- 363.24°C (rough estimate)
- Dichte
- 1.667
- Brechungsindex
- 1.5800 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- 1 M NaOH: 10 mg/mL, dark green
- Aggregatzustand
- powder
- pka
- 5.02±0.20(Predicted)
- Farbe
- tan to gray
- Wasserl?slichkeit
- <0.1 g/100 mL at 21 ºC
- Sensitive
- Air & Light Sensitive
- Merck
- 14,3547
- BRN
- 47549
- Stabilit?t:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- InChIKey
- AFSDNFLWKVMVRB-UHFFFAOYSA-N
- LogP
- 0.239 (est)
- CAS Datenbank
- 476-66-4(CAS DataBase Reference)
- EPA chemische Informationen
- Ellagic acid (476-66-4)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xi | ||
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R-S?tze: | 36/37/38 | ||
S-S?tze: | 26-36-36/37 | ||
WGK Germany | 3 | ||
RTECS-Nr. | DJ2620000 | ||
F | 8-10-23 | ||
HS Code | 29322090 | ||
Giftige Stoffe Daten | 476-66-4(Hazardous Substances Data) | ||
Toxizit?t | LD50 oral in rat: > 20gm/kg |
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Ellagsure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
cream to light yellow crystalline solid, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Mangiferaindica, Eucalyptuscitriodora, Lythrumsalicaria, Geranium sibiricum, Agrimoniapilosavar.japonica.Application
Ellagic acid is used in medicine and cosmetics, as an antioxidant, and has anti-cancer and anti-viral effects.Ellagic acid, a common plant polyphenol, is an inhibitor of glutathione S-transferase with Exhibits antitumor activity. It can be used for the determination of factor XIIa in plasma. Contact activation can occur in blood coagulation. It is also used as selective, ATP-competitive inhibitor of casein kinase 2 and a Topo I and II, FGR, GSK, and PKA inhibitor.
Verwenden
Ellagic Acid is a phenol antioxidant found naturally in various fruits and vegetables. Ellagic Acid was shown to exhibit high levels of hemostatic, antineoplastic, antimutagenic, antiproliferative and antioxidant properties in studies, which suggests its potential health benefits following ellagic acid consumption.synthetische
Ellagic acid is mainly extracted from plants, and it is present in several fruits such as cranberries, strawberries, raspberries, and pomegranates. Usually, the raw materials are degreasing and then extracted with an alkaline aqueous solution or extracted with ethanol. Then, after removing water-soluble proteins and gliadins, the sugar ligands can be decomposed by enzymes to obtain purer ellagic acid.Definition
ChEBI: Ellagic acid is an organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates. It has a role as an antioxidant, a food additive, a plant metabolite, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an EC 1.14.18.1 (tyrosinase) inhibitor, an EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor, an EC 2.4.1.1 (glycogen phosphorylase) inhibitor, an EC 2.5.1.18 (glutathione transferase) inhibitor, an EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor, an EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor, an EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor, a skin lightening agent, a fungal metabolite, an EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor and a geroprotector. It is an organic heterotetracyclic compound, a cyclic ketone, a lactone, a member of catechols and a polyphenol. It is functionally related to a gallic acid.Allgemeine Beschreibung
Cream-colored needles (from pyridine) or yellow powder. Odorless.Air & Water Reaktionen
Insoluble in water.Reaktivit?t anzeigen
Ellagic acid reacts as a weak acid. Incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated. Heat is also generated by the acid-base reaction between phenols and bases. May be sulfonated exothermically very readily (for example, by concentrated sulfuric acid at room temperature). May be nitrated very rapidly, even by dilute nitric acid.Brandgefahr
Flash point data for Ellagic acid are not available; however, Ellagic acid is probably combustible.Biologische Aktivit?t
Selective, ATP-competitive inhibitor of casein kinase 2 (CK2) (IC 50 values are 40, 2900, 3500, 4300 and 9400 nM for CK2, Lyn, PKA, Syk? and FGR respectively). Exhibits antioxidant, antitumor and anticarcinogenic activity and also inhibits glutathione S-transferase.Anticancer Research
Ellagic acid is a naturally occurring phenolic constituent present in natural productsand nuts, most elevated amounts of which are found in raspberries (Daniel et al.1990). EA is considered as a potent anticarcinogenic and antimutagenic compound.EA shows anti-angiogenic property by repressing PDGF-R movement and phosphorylationof its substrate. It can intrude with endothelial cell-associated VEGR-2phosphorylation bringing about the restraint of the downstream signaling activatedby this receptor and in the hindrance of two key events fundamental in angiogenesis,i.e., EC movement and morphogenic separation into capillary-like structure. In parallel,EA indicated robust inhibitory activity against perivascular cells through itsrestraint of PDGF-R action and signaling prompting hindrance of VSMC relocation(Labrecque et al. 2005).It is a phenolic compound extracted from pomegranate. It is an antiproliferative andantioxidant compound (Murakami et al. 1996). It induces apoptosis in cancer cellsof the prostate and breast and prevents the process of metastasis in different cancers(Singh et al. 2016b).
l?uterung methode
This antioxidant crystallises from pyridine. It forms a dark green solution in aqueous N NaOH. The tetraactetate dilactone crystallises from Ac2O, with m 340o. [Beilstein 19 H 261, 19 III/IV 3164, 19/7 V 108.]Ellagsure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ellagsure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 617)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
BINBO BIOLOGICAL CO.,LTD | +8618629063126 |
info@binbobiological.com | China | 346 | 58 |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2993 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 997 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12795 | 58 |
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 |
sales06@tgybio.com | China | 903 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5893 | 58 |
Chongqing Zhihe Biopharmaceutical Co., Ltd. | +8618580541567 |
sales@zhswyy.com | China | 303 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 |
sales02@sdzhonghuimaterial.com | China | 983 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 970 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 3002 | 58 |
476-66-4(Ellagsure)Verwandte Suche:
α-Hydroxy-o-tolyl-β-D-glucopyranosid
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyron
Folsure
Hyaluronsure
Zitronensure
ACETIC ACID
ASCORBICACID
3,4,5-Trihydroxybenzoesure
(R)-10-β-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)anthracen-9(10H)-on
Ellagsure
- gallogen(astringent)
- lagistase
- TIMTEC-BB SBB006501
- 2,3,7,8-tetrahydroxy(1)benzopyrano(5,4,3-cde)(1)benzopyran-5,10-dione
- ELLAGIC ACID
- BENZOARIC ACID
- AKOS NCG1-0028
- 4,4',5,5',6,6'-HEXAHYDROXYDIPHENIC ACID 2,6,2',6'-DILACTONE
- 4,4',5,5',6,6'-HEXAHYDROXYDIPHENIC ACID DILACTONE
- Ellagic acid hydrate technical grade
- Ellagic acid, >=98%
- 4,3-cde)(1)benzopyran-5,10-dione,2,3,7,8-tetrahydroxy-(1)benzopyrano(
- 4,3-cde][1]benzopyran-5,10-dione,2,3,7,8-tetrahydroxy-[1]-Benzopyrano[5
- alizarineyellow
- c.i.55005
- c.i.75270
- elagostasine
- 4,4,5,5-tetrahydroxybiphenyl-2,6:2,6-biscarbolactone
- ellagic acid from chestnut bark
- EllagicAcidDihydrate97%
- EllagicAcid(NutgallPe)95%ByHplc
- EllagicAcid99%
- 2,3,7,8-TETRAHYDROXY-CHROMENO[5,4,3-CDE]CHROMENE-5,10-DIONE
- ELLAGICACID,95%(BULK
- ELLAGIC ACID(RG)
- 2,3,7,8-Tetrahydroxy[1]benzopyrano[5,4,3-cde][1] benzopyran-5,7-dione
- Ellagic acid 4,4’,5,5’,6,6’-Hexahydroxydiphenic acid 1,6,1’,6’-dilactone
- ELLAGIC ACID 95%
- ELLAGIC ACID anhydrous
- [1]Benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione, 2,3,7,8-tetrahydroxy-
- Pomegranate fruit extract powder
- Ellagic acid hydrate, 97%, may cont. up to 12% water
- 2,6,2′,6′-dilactone Ellagic acid hydrate
- 4,4′,5,5′,6,6′-Hexahydroxydiphenic acid
- Ellagic Acid Hydrate, May Cont. up to 12% Water
- Elllagic Acid
- Ellagic acid 476-66-4
- Punica Granatum Pericarp Extract
- Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem
- Ellagic Acid (TBBD)
- Ellagic Acid Standard
- Liposomal Ellagic Acid, Water-Soluble Ellagic Acid
- ic acid hydrate
- agic acid hydrate
- Ellagic acid, 95%+
- Ellagic acid, techincal grade
- eleagicacid
- Ellagic
- TBBD
- Pomegranate Peel Polyphenols
- Pomegranate Peel Extract / Ellagic Acid
- Ellagic Acid (25 mg)
- ELLAGIC ACID(RG) 1g
- ELLAGIC ACID(RG) 5g
- 476-66-4
- C14H16O8
- C14H6O82H2O
- C14H6O8