Sitagliptin phosphate
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- CAS-Nr.
- 654671-78-0
- Englisch Name:
- Sitagliptin phosphate
- Synonyma:
- Sitagliptin Phosphat;3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazin-7(8H)-yl)-4-(2,4,5-t;(3R)-3-aMino-1-[3-(trifluoroMethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;SIT-11;CS-1358;sitagpliptin;Sitagliptin, MK 0431;Sitagliptin phosphate;Sitagliptin Phosphatec;Sitagliptin phosphate salt
- CBNumber:
- CB71179744
- Summenformel:
- C16H15F6N5O.H3PO4
- Molgewicht:
- 505.31
- MOL-Datei:
- 654671-78-0.mol
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Sitagliptin phosphate Eigenschaften
- Schmelzpunkt:
- 202-204°C
- storage temp.
- -20°C Freezer
- L?slichkeit
- Methanol (Slightly, Heated), Water (Sparingly, Sonicated)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- InChI
- InChI=1S/C16H15F6N5O.H3O4P/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4)
- InChIKey
- IQFYVLUXQXSJJN-UHFFFAOYSA-N
- SMILES
- C(C1=CC(F)=C(F)C=C1F)C(N)CC(=O)N1CCN2C(C(F)(F)F)=NN=C2C1.P(O)(O)(O)=O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Sitagliptin phosphate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Sitagliptin is the first novel dipeptidyl peptidase IV inhibitor
from Merck for the treatment of type 2 diabetes without
weight gain and the incidence of hypoglycemia was similar
to placebo. Sitagliptin acts by enhancing the body’s incretin
system, which helps to regulate glucose by affecting β
and α cells in the pancreas.
Chemische Eigenschaften
White Solid
Verwenden
A trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.
Allgemeine Beschreibung
Sitagliptin phosphate is the 1:1 phosphoric acid salt ofsitagliptin free base (i.e., (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)-2-butanamine), and is marketed(Junuvia, 2006) in 25-, 50-, and 100-mg tablets. Acombination product with metformin (Janumet, 2007) intwo strengths (50 mg/500 mg and 50 mg/1,000 mgsitagliptin/metformin) is also available, and sitagliptin mayalso be prescribed with a thiazolidinedione, or possibly a sulfonylurea.The phosphate salt provides very high water solubility.The bioavailability of orally administered sitagliptinis～87%. The drug exhibits relatively low plasma protein binding (～38%), a relatively large volume of distribution(198 L), and a terminal elimination half-life of 12 hours.About 79% of a 100-mg oral dose is excreted unchanged inurine, the balance as trace-level metabolites (CYP3A4, lessercontribution by CYP2C8) in urine or feces: 87% of administeredradioactivity is excreted in urine, and 13% in feces.Active tubular excretion is reported to play a key role in renalclearance of unchanged drug, and may be mediated at least inpart via the organic anion transporter hOAT-3.
Sitagliptin phosphate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Sitagliptin phosphate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 371)Lieferanten
654671-78-0()Verwandte Suche:
[4-(4-Amino-6,7-dimethoxy-quinazolin-2- yl)piperazin-1-yl]-(2,5-dioxabi cyclo[4.4.0]deca-6,8,10-trien-4-yl)methanone
Oseltamivir phosphate
Prazosin
Trinatriumorthophosphat
Doxazosin mesylate
PHOSPHATE BUFFER
Alfuzosin
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride
2,3,5,6-Tetramethyl-pyrazin
Terazosin
2,6-Dimethyloct-7-en-2-ol
Tricalciumbis(orthophosphat)
Sitagliptin
Tributylphosphat
Pregna-1,4-dien-3,20-dion, 9-Fluor-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, Dinatriumsalz, (11β,16β)-
Hexadecyldihydrogenphosphat
Tylosin, Phosphat (Salz)
phosphate
- 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine-phosphate
- Sitagliptin phosphate
- 4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate
- sitagpliptin
- Sitagliptin phosphate 4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate
- Sitagliptin phosphate/Sitagliptin phosphate Monohydrate/Sitagliptin
- Sitagliptin phosphate (Cas:654671-78-0...
- (3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone phosphate
- 1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)-, phosphate (1:1)
- Sitagliptin, MK 0431
- CS-1358
- Sitagliptin phosphate salt
- 99% Sitagliptin Phosphate?
- Sitagliptin phosphate USP/EP/BP
- Sitagliptin phosphate (API)
- Sitagliptin PhosphateQ: What is
Sitagliptin Phosphate Q: What is the CAS Number of
Sitagliptin Phosphate Q: What is the storage condition of
Sitagliptin Phosphate
- Sitagliptin Phosphatec
- 3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazin-7(8H)-yl)-4-(2,4,5-t
- (3R)-3-aMino-1-[3-(trifluoroMethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
- Sitagliptin Phosphat
- SIT-11
- Sitagliptin Phosphate (Monohydrate and Anhydrous)
- Siagliptin phosphate monohydrate
- Sitagliptin Impurity 19 Phosphate
- Sitagliptin Impurity 14 Phosphate
- 654671-78-0
- C16H15F6N5OH3O4P
- C16H15F6N5OH3PO4
- API
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Pharmaceutical intermdiate
- All Inhibitors
- Inhibitors
- 654671-78-0
