Tributylphosphat Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSE, GERUCHLOSE, VISKOSE FLüSSIGKEIT.
CHEMISCHE GEFAHREN
Zersetzung beim Verbrennen unter Bildung giftiger Rauche mit Phosphoroxiden.
ARBEITSPLATZGRENZWERTE
TLV: 0.2 ppm (als TWA); BEI vorhanden; (ACGIH 2005).
MAK: 1 ppm (als TWA); Hautresorption; Spitzenbegrenzung: überschreitungsfaktor II(4); Krebserzeugend Kategorie 4; Schwangerschaft: Gruppe C; (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den K?rper durch Inhalation der D?mpfe, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C tritt eine gesundheitssch?dliche Kontamination der Luft nicht oder nur sehr langsam ein , viel schneller jedoch beim Versprühen oder Dispergieren.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Die Substanz reizt stark die Augen, die Haut und die Atemwege.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Beim Verschlucken sind Auswirkungen auf die Blase mit nachfolgenden Gewebesch?denm?glich .
LECKAGE
Pers?nliche Schutzausrüstung: Atemschutzfilter für organische Gase und D?mpfe. NICHT in die Umwelt gelangen lassen. Ausgelaufene Flüssigkeit in abdichtbaren Beh?ltern sammeln. Keine Kunststoffbeh?lter benutzen. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen.
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R38:Reizt die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R62:Kann m?glicherweise die Fortpflanzungsf?higkeit beeintr?chtigen.
R48/20:Gesundheitssch?dlich: Gefahr ernster Gesundheitssch?den bei l?ngerer Exposition durch Einatmen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R11:Leichtentzündlich.
S-S?tze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S46:Bei Verschlucken sofort ?rztlichen Rat einholen und Verpackung oder Etikett vorzeigen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
Beschreibung
On decomposition, TBP releases COx, toxic fumes of phosphoric acid, phosphorus oxides,
and/or phosphine. TBP is incompatible with strong oxidising agents and alkalis. The major
uses of TBP in industry are as a component of aircraft hydraulic fluid and as a solvent for
rare earth extraction and purification. Minor uses of TBP include use as a defoamer additive
in cement casings for oil wells, an anti-air entrainment additive for coatings and floor
finishes, as well as a carrier for fluorescent dyes. The major uses of TBP comprise over 80%
of the volume produced.
Chemische Eigenschaften
Stable, colorless liquid; odorless. Miscible
with most solvents and diluents; soluble in
water. Combustible.
Physikalische Eigenschaften
Clear, colorless to pale yellow, odorless, slightly flammable, oily liquid
Verwenden
Tributyl phosphate is used as an antifoaming agent; plasticizer for cellulose esters, lacquers, plastic, and vinyl resins; component in hydraulic fluids for aircraft control systems.
Vorbereitung Methode
Prepared by the reaction of phosphorus oxychloride with butyl alcohol.
Definition
ChEBI: A trialkyl phosphate that is the tributyl ester of phosphoric acid.
Allgemeine Beschreibung
Tributyl phosphate is an organophosphorus compound, which is widely used as a flame retardant and plasticizer in a variety of industrial products.
Air & Water Reaktionen
Water insoluble. Reacts slowly with water under basic conditions.
Reaktivit?t anzeigen
Tributyl phosphate is incompatible with strong oxidizing agents and strong bases. Attacks some forms of plastics and rubber .
Health Hazard
Tributyl phosphate is a neurotoxic compound and an irritant. The toxic effects are characteristic of organic phosphates. It inhibits cholinesterase activity and causes paralysis. Inaddition,itcancausedepressionofthecentralnervoussystem,aswellasirritationofthe skin,eyes,andrespiratorypassage.Inhalation toxicity data in the literature are inconsistent.
The oral toxicity in rats was low; the LD50 value was reported as 1189 mg/kg (NIOSH 1986).
The pure liquid instilled into rabbits’ eyes caused severe irritation but no permanent damage. The irritation effect on the skin is mild.
Tributyl phosphate exhibited teratogenic effects in rats. There is no report on its carcinogenicity..
Brandgefahr
Special Hazards of Combustion Products: Toxic fumes of PO x
Industrielle Verwendung
1. As an antifoaming agent.
2. As a plasticizer for cellulose esters, lacquers, plastics, and vinyl resins.
3. As a complexing agent in the extraction of heavy metals, especially for the
extraction of metal ions from solutions of reactor products in nuclear fuel
reprocessing.
4. As an aircraft hydraulic fluid.
5. As a heat exchange medium and dielectric.
6. As a pigment-grinding agent.
Sicherheitsprofil
Poison by
intraperitoneal and intravenous routes.
Moderately toxic by ingestion, inhalation,
and subcutaneous routes. Experimental
reproductive effects. A skin, eye, and
mucous membrane irritant. Combustible
when exposed to heat or flame. To fight
fire, use CO2, dry chemical, fog, mist. When
heated to decomposition it emits toxic
fumes of POx.
Carcinogenicity
TBP was not genotoxic in a variety of
in vivo and in vitro assays.7 It has been suggested
that the carcinogenic effects of TBP are
species- and organ specific. The necrotic
actions of TBP (or a metabolite) on rat urinary
bladder epithelium may induce chronic repair
processes that cause the normal epithelium to
be transformed into its metaplastic and neoplastic
forms.
TBP was not teratogenic when administered
to rats and rabbits during gestation;
fetotoxic effects (delayed ossification and reduced
fetal body weights) occurred in rats at
doses that caused severe maternal toxicity.
There was no evidence of reproductive toxicity
or reproductive organ pathology in twogeneration
studies in rats fed TBP in the diet.
Environmental Fate
Biological. Indigenous microbes in Mississippi River water degraded tributyl phosphate to
carbon dioxide. After 4 wk, 90.8% of the theoretical carbon dioxide had evolved (Saeger et al.,
1979).
Chemical/Physical. Complete hydrolysis yields 1-butanol and phosphoric acid via the
intermediates dibutyl phosphate and monobutyl phosphate (Thomas and Macaskie, 1996).
l?uterung methode
The main contaminants in commercial samples are organic pyrophosphates, monoand dibutyl phosphates and butanol. It is purified by washing successively with 0.2M HNO3 (three times), 0.2M NaOH (three times) and water (three times), then fractionally distilled under vacuum. [Yoshida J Inorg Nucl Chem 24 1257 1962.] It has also been purified via its uranyl nitrate addition compound, obtained by saturating the crude phosphate with uranyl nitrate. This compound is crystallised three times from n-hexane by cooling to -40o, and then decomposed by washing with Na2CO3 and water. Hexane is removed by steam distillation; the water is then evaporated under reduced pressure, and the residue is distilled under reduced pressure. [Siddall & Dukes J Am Chem Soc 81 790 1959.] Alternatively, wash it with water, then with 1% NaOH or 5% Na2CO3 for several hours, then finally with water. Dry it under reduced pressure and fractionate it carefully under vacuum. It is a stable colourless oil, sparingly soluble in H2O (1mL dissolves in 165mL of H2O), but freely miscible in organic solvents. [Kuivila & Masterton J Am Chem Soc 74 4953 1952, Cox & Westheimer J Am Chem Soc 80 5441 1958, 31P NMR: Van Wazer J Am Chem Soc 78 5715 1956, Fertig et al. J Chem Soc 1488 1957, Beilstein 1 IV 1531.]
Waste disposal
Tributyl phosphate is dissolved in a combustible solvent and is burned in a chemical incinerator equipped with an afterburner and scrubber.
Tributylphosphat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
