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Natrium-2-[(2,6-dichlor-3-methylphenyl)amino]benzoat

MECLOFENAMATE SODIUM Struktur
6385-02-0
CAS-Nr.
6385-02-0
Bezeichnung:
Natrium-2-[(2,6-dichlor-3-methylphenyl)amino]benzoat
Englisch Name:
MECLOFENAMATE SODIUM
Synonyma:
ci583;C02996;Movens;meclomen;Meclonax;Meclofenamate;sodiummeclophenamate;SODIUM MECLOFENAMATE;MECLOFENAMATE SODIUM;MECLOFENAMATESODIUM,USP
CBNumber:
CB7102365
Summenformel:
C14H10Cl2NO2.Na
Molgewicht:
318.13
MOL-Datei:
6385-02-0.mol

Natrium-2-[(2,6-dichlor-3-methylphenyl)amino]benzoat Eigenschaften

Schmelzpunkt:
287-291 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
White solid.
Farbe
White to Off-White
Wasserl?slichkeit
Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol
Merck 
14,5779
Stabilit?t:
Hygroscopic
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
RTECS-Nr. CB2975500
HS Code  2922498050
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Natrium-2-[(2,6-dichlor-3-methylphenyl)amino]benzoat Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 μM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.

Verwenden

Meclofenamate Sodium is an NSAID used in the treatment of chronic pain.

Definition

ChEBI: An organic sodium salt derived from meclofenamic acid. Its monohydrate is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.

Indications

Meclofenamate sodium (Meclomen) is prescribed for rheumatoid arthritis and osteoarthritis. The fenamates show no clear superiority in antiinflammatory activity and may produce more adverse effects than other NSAIDs.

Allgemeine Beschreibung

Meclofenamate sodium (Meclomen) is available for use inthe treatment of acute and chronic RA, OA, and primarydysmenorrhea. It is metabolized in a similar manner tomefenamic acid discussed above, thus a similar restriction isalso applied to meclofenamate. The most significant side effectsare GI, including diarrhea.

Pharmakokinetik

Meclofenamate sodium is rapidly and almost completely absorbed following oral administration, reaching peak plasma levels within 2 hours. It is highly bound to plasma proteins (99%) and has a plasma half-life of 2 to 4 hours. Metabolism involves oxidation of the methyl group, aromatic hydroxylation, monodehalogenation, and conjugation. Urinary excretion accounts for approximately 75% of the administered dose. The major metabolite is the product of 3′-methyl oxidation and has been shown to possess anti-inflammatory activity.
Metabolism of meclofenamic acid..jpg

Clinical Use

Meclofenamate sodium is indicated for the relief of mild to moderate pain, the acute and chronic treatment of rheumatoid arthritis and osteoarthritis, the treatment of primary dysmenorrhea, and the treatment of idiopathic, heavy menstrual blood loss.

Natrium-2-[(2,6-dichlor-3-methylphenyl)amino]benzoat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Natrium-2-[(2,6-dichlor-3-methylphenyl)amino]benzoat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 120)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 22784 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 49978 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43340 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58

6385-02-0(Natrium-2-[(2,6-dichlor-3-methylphenyl)amino]benzoat)Verwandte Suche:


  • MECLOFENAMIC ACID SODIUM SALT MONOHYDRATE
  • Sodium Meclofenamate Monohydrate
  • C02996
  • SODIUM MECLOFENAMATE
  • meclofenamic acid sodium
  • MECLOFENAMIC ACID SODIUM SALT 99%
  • Meclofenamate
  • MECLOFENAMATESODIUM,USP
  • sodium meclofenamate (anhydrous)
  • sodium2-((2,6-dichloro-3-methylphenyl)amino)benzoate
  • sodiummeclophenamate
  • MECLOFENAMATE SODIUM
  • MECLOFENAMATE SODIUM HYDRATE
  • MECLOFENAMATE SODIUM SALT
  • MECLOFENAMIC ACID SODIUM SALT
  • 2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]-BENZOIC ACID, MONOSODIUM SALT
  • 2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]BENZOIC ACID SODIUM SALT
  • sodium,2-(2,6-dichloro-3-methylanilino)benzoate
  • 2-((2,6-dichloro-3-methylphenyl)amino)-benzoicacimonosodiumsalt
  • ci583
  • meclomen
  • n-(2,6-dichloro-m-tolyl)-anthranilicacimonosodiumsalt
  • Benzoic acid, 2-[(2,6-dichloro-3-Methylphenyl)aMino]-, sodiuM salt
  • Meclofenamate Sodium (500 mg)
  • 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic Acid Sodium Salt Meclofenamic Acid Sodium Salt
  • SodiuM MeclofenaMate 
  • Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-, sodium salt (1:1)
  • 2-[(2,6-dichloro-3-methylphenyl)amino]-benzoic acid, sodium salt (1:1)
  • Sodium Meclofenamate Hydrate
  • sodium 2-(2,6-dichloro-3-methylanilino)benzoate hydrate
  • SodiumMeclofenamateMonohydrate>
  • Meclonax
  • Movens
  • 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt monohydrate
  • MECLOFENAMATE SODIUM USP/EP/BP
  • Meclofenamate Sodium (Meclofenamic acid sodium)
  • Meclofenamate Sodium (1377803)
  • Endogenous Metabolite,Meclofenamate,Inhibitor,Meclofenamic acid sodium,inhibit,Meclofenamic acid,Gap Junction Protein
  • Sodium Meclofenamate Monohydrate, ≥ 98.0%
  • 6385-02-0
  • 6358-02-0
  • C14H10Cl2NO2NaH2O
  • C14H10Cl2NNaO2H2O
  • C14H10Cl2NNaO2xH2O
  • C14H11Cl2NNaO2
  • Lipoxygenase (5-) and cyclooxygenase
  • L to O
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • BioChemical
  • Biochemicals and Reagents
  • MECLOMEN
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