成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Azelainsure

Azelaic acid Struktur
123-99-9
CAS-Nr.
123-99-9
Bezeichnung:
Azelainsure
Englisch Name:
Azelaic acid
Synonyma:
NONANEDIOIC ACID;Azelex;azelaic;ninandioic acid;ANCHOIC ACID;nonanedioate;Azelaic acid powder;ZK-62498;Azalaic Acid;nonadioic acid
CBNumber:
CB6852982
Summenformel:
C9H16O4
Molgewicht:
188.22
MOL-Datei:
123-99-9.mol

Azelainsure Eigenschaften

Schmelzpunkt:
98 °C
Siedepunkt:
286 °C100 mm Hg(lit.)
Dichte
1,029 g/cm3
Dampfdichte
6.5 (vs air)
Dampfdruck
<1 mm Hg ( 20 °C)
Brechungsindex
1.4303
Flammpunkt:
215 °C
storage temp. 
Store below +30°C.
L?slichkeit
2.4g/l
Aggregatzustand
Slightly Crystalline Powder or Flakes
pka
4.53, 5.33(at 25℃)
Farbe
White to slightly yellow
PH
3.5 (1g/l, H2O)
Wasserl?slichkeit
2.4 g/L (20 ºC)
Merck 
14,905
BRN 
1101094
Stabilit?t:
Stable. Combustible. Incompatible with bases, strong oxidizing agents. Readily biodegrades in soil and water with >70% DOC reduction after 28 days.
InChIKey
BDJRBEYXGGNYIS-UHFFFAOYSA-N
LogP
1.57 at 25℃
CAS Datenbank
123-99-9(CAS DataBase Reference)
NIST chemische Informationen
Nonanedioic acid(123-99-9)
EPA chemische Informationen
Azelaic acid (123-99-9)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 24/25-36-26
WGK Germany  1
RTECS-Nr. CM1980000
TSCA  Yes
HS Code  29171390
Giftige Stoffe Daten 123-99-9(Hazardous Substances Data)
Toxizit?t LD50 orally in Rabbit: > 4000 mg/kg LD50 dermal Rat > 10 g/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P337+P313 Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Azelainsure Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Azelaic acid is a topical antiacne agent which exerts its therapeutic action through a myriad of antimicrobial, antiproliferative and cytostatic effects. In vitro, azelaic acid hasbeen shown to inhibit DNA polymerases in several tumor cell lines.

Chemische Eigenschaften

Azelaic acid is an organic compound with the formula (CH2)7(CO2H)2. This saturated dicarboxylic acid exists as a white powder. It is found in wheat, rye, and barley. It is a component of a number of hair and skin conditioners.

Verwenden

Azelaic acid is used in lacquers, alkyd resins, plasticizers, adhesives, polyamides, urethane elastomers, and organic syntheses. Azelaic acid is also used in treating of acne.

Vorbereitung Methode

Azelaic acid is industrially produced by the ozonolysis of oleic acid. The side product is nonanoic acid. It is produced naturally by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. The bacterial degradation of nonanoic acid gives azelaic acid.

Indications

Azelaic acid (Azelex) is a naturally occurring dicarboxylic acid produced by the yeast Malassezia furfur. Azelaic acid inhibits tyrosinase, a rate-limiting enzyme in the synthesis of the pigment melanin. This may explain why diminution of melanin pigmentation occurs in the skin of some patients with pityriasis versicolor, a disease caused by M. furfur. Azelaic acid is bacteriostatic against a number of species thought to participate in the pathogenesis of acne, including Propionibacterium acnes. The drug may also reduce microcomedo formation by promoting normalization of epidermal keratinocytes.

synthetische

Azelaic acid is made by the ozonolysis of oleic acid:

123-99-9 synthesis

Application

Azelaic acid, also known as azalea acid, is a white to slightly yellow powder. Azelaic acid is a medium-long chain dibasic acid[1]. In recent years, with the rapid development of the organic synthetic chemical industry, the demand for medium and long chain dibasic acids is increasing. The medium and long chain dibasic acids and their derivatives have a wide range of industrial applications and a broad product market.

Allgemeine Beschreibung

Azelaic acid is used as a therapeutic agent in dermatology.

Mechanism of action

Naturally occurring dicarboxylic acid that is bacteriostatic to Propionibacterium acnes. It also decreases conversion of testosterone to 5{pi}ga-dihydrotestosterone (DHT) and alters keratinization of the microcomedone. It may also be beneficial in the treatment of melasma. The mechanism of action is not fully understood. Deoxyribonucleic acid (DNA) synthesis is reduced, and mitochondrial cellular energy products are inhibited in melanocytes.

Biotechnological Applications

In plants, azelaic acid serves as a "distress flare" involved in defense responses after infection. It serves as a signal that induces the accumulation of salicylic acid, an important component of a plant's defensive response.

Clinical Use

Azelaic acid is used for the treatment of mild to moderate acne, particularly in cases characterized by marked inflammation-associated hyperpigmentation.

Sicherheitsprofil

Low toxicity by ingestion. A skinand eye irritant. Closely related to glutaric acid and adipicacid. Combustible when exposed to heat or flame; canreact with oxidizing materials.

l?uterung methode

Recrystallise it from H2O(charcoal) or thiophene-free *benzene. The acid can be dried by azeotropic distillation with toluene, the residual toluene solution is then cooled and filtered, and the precipitate is dried in a vacuum oven. It has been purified by zone refining or by sublimation onto a cold finger at 10-3torr. It distils above 360o with partial formation of the anhydride. The dimethyl ester has m –3.9o and b 140o/8mm. [Hill & McEwen Org Synth Coll Vol II 53 1943, Beilstein 2 IV 2055.]

Azelainsure Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Azelainsure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 877)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
Guangzhou TongYi biochemistry technology Co.,LTD
+8613073028829
mack@tongyon.com China 2994 58
ZhenYiBio Technology Inc
+8615309206328
alexxue@zhenyibio.com China 296 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Wuhan Quanjinci New Material Co.,Ltd.
+86-15271838296; +8615271838296
kyra@quanjinci.com China 1512 58
BINBO BIOLOGICAL CO.,LTD
+8618629063126
info@binbobiological.com China 423 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118
xie@china-sinoway.com China 988 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
Hebei Dangtong Import and export Co LTD
+86-13910575315 +86-13910575315
admin@hbdangtong.com China 1000 58

123-99-9(Azelainsure)Verwandte Suche:


  • Azelaic acid(Nonanedioic acid)
  • Azelaic Acid,1,7-Heptanedicarboxylic Acid
  • Nonanedioic acid 1,7-Heptanedicarboxylic Acid
  • 1.7-Heptanedic
  • Azelaic acid technical, ~85% (GC)
  • Azelaic acid Vetec(TM) reagent grade
  • Azelaic acid5x100g
  • Anchoic acid,Lepargylic acid
  • Azelaic acid≥ 99% (Assay)
  • Azelainic acid
  • Emerox 1110
  • Emerox 1144
  • emerox1110
  • emerox1144
  • Emery's L-110
  • AZELAIC ACID TECH. 85-90% FLAKES
  • AZELAIC ACID 98+%
  • Anchoec acid
  • nonanedionic acid
  • Azelainsure
  • Azelaic acid, 85-90%, tech., flakes
  • Heptanedicarboxylic acid
  • heptanedicarboxylicacid
  • n-Nonanedioic acid
  • Skinoren
  • AZELAIC ACID [1,7-HEPATANEDICARBOXYLIC ACID]
  • Azelaic acid, 95+%
  • 1,7-HEPTANEDICARBOXYLIC
  • LEPARGYLIC ACID
  • AZELAIC ACID
  • DICARBOXYLIC ACID C9
  • NONANEDIOC ACID
  • N-HEPTANE-1,7-DICARBOXYLIC ACID
  • RARECHEM AL BO 0186
  • 1,7-HEPTANEDICARBOXYLIC ACID
  • Azelaicacidtech
  • 1,7-Dicarboxyheptane
  • Azelaic acid, technical grade
  • Azelaic acid, tech., flakes
  • Azeloic acid
  • Azelaic acid( Micronized )
  • Azelaic acid, 98% 25GR
  • Azelaic Acid 98%
  • 1,7-Heptanedicarboxylic Acid Nonanedioic Acid
  • NanoLiposomal Azelaic acid
  • Azelaic acid Manufacturer
  • Water-soluble azelaic acid
  • Azelaic Acid >
  • Azelaic acid, 99%, reagent grade
  • Finacea
  • zelaic acid
  • AZELAIC ACID FOR SYNTHESIS 1 KG
  • AZELAIC ACID FOR SYNTHESIS 100 G
  • nonane diacid
  • Azelaic acid Gel, Azelaic acid Cream, Topical Azelaic acid,Azelaic acid Hydrogel
  • Azelaic acid Smart NanoGel
  • Azelaic acid USP/EP/BP
  • Azelaic Acid Solisome
Copyright 2019 ? ChemicalBook. All rights reserved