Astemizol
|
|
Astemizol Eigenschaften
- Schmelzpunkt:
- 172.9°C
- Siedepunkt:
- 627.3±65.0 °C(Predicted)
- Dichte
- 1.1587 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: >20mg/mL
- pka
- pKa 4.85(H2O t=25.0 I=0.025) (Uncertain);8.69(H2O t=25.0 I=0.025) (Uncertain)
- Aggregatzustand
- powder
- Farbe
- Crystals
- Wasserl?slichkeit
- It is soluble in DMSO (25 mg/ml ), ethanol (25 mg/ml), chloroform, methanol, and water (partly miscible).
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xn | ||
---|---|---|---|
R-S?tze: | 22-36/37/38 | ||
S-S?tze: | 26-36 | ||
RIDADR | UN 2811 6.1 / PGII | ||
WGK Germany | 3 | ||
RTECS-Nr. | DD8968000 | ||
HS Code | 2933992600 | ||
Giftige Stoffe Daten | 68844-77-9(Hazardous Substances Data) | ||
Toxizit?t | LD50 orl-rat: >2560 mg/kg AIPTAK 251,39,81 |
Bildanzeige (GHS) | |||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alarmwort | Warnung | ||||||||||||||||||||||||||||
Gefahrenhinweise |
|
||||||||||||||||||||||||||||
Sicherheit |
|
Astemizol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Astemizole belongs to the second-generation class of non-sedating, non-anticholinergic antihistamines. Its non-sedating properties appear to result from its poor penetration of the blood brain barrier. As a result it shows no potentiation of CNS depressants, including alcohol. Its long half-life allows once-daily dosing.Chemische Eigenschaften
Crystalline SolidVerwenden
Astemizole is used for preventing and treating severe seasonal and chronic allergic rhinitis, allergic conjunctivitis, hives, Quinke’s edema, other allergic conditions and dermatitis. Synonyms of this drug are hismanal, histazol, and others.Definition
ChEBI: A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.Weltgesundheitsorganisation (WHO)
The first clinically interesting histamine ti-antagonists were introduced in the late forties and early fifties. Several histamine ti-antagonists have a similar cardiac effect to that seen with astemizole and terfenadine. Serious cardiovascular adverse reactions have been reported when used concomitantly with imidazole antifungals and macrolide antibiotics.Biologische Aktivit?t
Orally active, potent histamine H 1 antagonist (IC 50 = 4 nM) that displays 20-fold, > 250-fold and > 250-fold selectivity over 5-HT, dopamine and muscarinic acetylcholine receptors respectively. Exhibits antimalarial activity in multidrug resistant strains in vitro (IC 50 = 227 - 734 nM). Also potent hERG K + channel blocker (IC 50 = 0.9 nM) that displays cardiotoxicity in vivo .Sicherheitsprofil
Poison by subcutaneous andintravenous routes. Moderately toxic by ingestion. Humansystemic effects by ingestion: arrhythmias, coma, nauseaor vomiting, somnolence. When heated to decompositionit emits toxic fumes of F?? and NOx.Astemizol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Astemizol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 179)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21639 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32820 | 60 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49374 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-15319487004 |
1015@dideu.com | China | 2130 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 31991 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 7724 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 |
sales@afinechem.com | China | 15361 | 58 |
Shanghai kingmorn biotechnology Co.,Ltd. | 021-62200788 15000569291 |
2199306478@qq.com | CHINA | 99 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10473 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
68844-77-9(Astemizol)Verwandte Suche:
- 1-((4-fluorophenyl)methyl)-n-(1-(2-(4-methoxyphenyl)ethyl)-4-piperidinyl)-1h-b
- r45312
- retolen
- ASTEMIZOLE
- 1-[(4-FLUOROPHENYL)METHYL]-N-[1-[2-(4-METHOXYPHENYL)ETHYL]-4-PIPERIDINYL]-1H-BENZIMIDAZOL-2-AMINE
- (1-[4-FLUOROBENZYL]-2-[1-(4-METHOXYPHENETHYL)PIPERIDIN-4-YL] AMINOBENZIMIDAZOLE
- Astemisan
- R 43512
- Waruzol
- Histazol
- Metodik
- Novo-Nastizol A
- Retolan:Waruzol
- 1-(p-Fluorobenzyl)-2-((1-(b-methoxyphenethyl)-4-piperidyl)amino)benzimidazole
- 1-(4-Fluorobenzyl)-2-[[1-(4-methoxyphenethyl)-4-piperidyl]amino]-1H-benzimidazole
- MJD-30
- AsteMizole, BP
- 1-[(4-fluorophenyl)Methyl]-N-{1-[2-(4-Methoxyphenyl)ethyl]piperidin-4-yl}-1H-1,3-benzodiazol-2-aMine
- 1-(p-fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzim
- 1-(p-fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole
- 1h-benzimidazol-2-amine,1-((4-fluorophenyl)methyl)-n-(1-(2-(4-methoxyphenyl)et
- astemison
- astemizol
- astemizol(inn-spanish)
- astemizolum(inn-latin)
- benzimidazole,1-(p-fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)
- enzimidazol-2-amine
- hestazol
- hisamanal
- hismanal
- histamen
- histaminos
- hl)-4-piperidinyl)-
- idazole
- laridal
- metodih
- novo-mastizola
- paralergin
- r42512
- [1-(4-fluorobenzyl)benzimidazol-2-yl]-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidyl]amine
- 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl]benzimidazol-2-amine
- Astemizole (200 mg)
- Astemizole (1044301)
- 68844-77-9 Astemizole
- AstemizoleQ: What is Astemizole Q: What is the CAS Number of Astemizole Q: What is the storage condition of Astemizole Q: What are the applications of Astemizole
- Astemizole USP/EP/BP
- 1H-Benzimidazol-2-amine, 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-
- 1-(4-Fluorobenzyl)-N-(1-(4-methoxyphenethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2-amine
- Astemizole(R43512)
- 68844-77-9
- 68844-79-9
- C28H33FN4O
- C28H31FN4O
- Building Blocks
- Heterocyclic Building Blocks
- Benzimidazoles
- ASCABIOL
- Amines