(3β,24S)-Cholest-5-ene-3,24-diol Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
24(S)-
hydroxy Cholesterol is a side-
chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-
brain barrier to the systemic circulation where it can modulate cell signaling, be used for further sterol biosynthesis, or be metabolized in the liver. 24(S)-
hydroxy cholesterol potently activates LXRα and LXRβ nuclear receptors (EC
50 = 4 and 3 μM, respectively), causing upregulation of cholesterol-
lowering genes. In the brain, this oxysterol controls cholesterol processing to facilitate neurological repair during Alzheimer’s disease and other neuropathological conditions.
Verwenden
(3β,24S)-Cholest-5-ene-3,24-diol is used as a biomarker in the analysis of disease.
Allgemeine Beschreibung
24(S)-hydroxycholesterol (24HC) is synthesized from cholesterol in brain dendrites by the action of enzyme cholesterol 24-hydroxylase (CYP46A1). It is catabolized to bile acids in the liver.
(3β,24S)-Cholest-5-ene-3,24-diol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
