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Hydroxytyrosol

Hydroxytyrosol  Struktur
10597-60-1
CAS-Nr.
10597-60-1
Englisch Name:
Hydroxytyrosol
Synonyma:
HYDROXYTYROSOL;4-(2-hydroxyethyl)benzene-1,2-diol;3-HYDROXYTYROSOL;3,4-DIHYDROXYPHENETHYL ALCOHOL;3,4-DIHYDROXYPHENYLETHYL ALCOHOL;Dopet;Dopaol;Dihydroxyphenylethanol;2-(3,4-DIHYDROXYPHENYL)ETHANOL;(S)-2-amino-3-(4-hydroxyphenyl)propane-1,1-diol
CBNumber:
CB6477710
Summenformel:
C8H10O3
Molgewicht:
154.16
MOL-Datei:
10597-60-1.mol

Hydroxytyrosol Eigenschaften

Siedepunkt:
355.4±27.0 °C(Predicted)
Dichte
1.321±0.06 g/cm3(Predicted)
Brechungsindex
1.5810-1.5860
storage temp. 
-20°C
L?slichkeit
Acetonitrile (Slightly), DMSO (Slightly), Ethyl Acetate (Sparingly), Methanol (Slightly)
Aggregatzustand
Solid
pka
9.72±0.10(Predicted)
Farbe
Colourless to Yellow Sticky Oil
BRN 
2208118
Stabilit?t:
Hygroscopic
InChI
InChI=1S/C8H10O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,9-11H,3-4H2
InChIKey
JUUBCHWRXWPFFH-UHFFFAOYSA-N
SMILES
C1(O)=CC=C(CCO)C=C1O
LogP
0.020 (est)
CAS Datenbank
10597-60-1(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26
WGK Germany  3
HS Code  29072990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit

Hydroxytyrosol Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Brown oil is derived from Olea europaea leaves and is soluble in methanol, DMSO, and other solvents but insoluble in petroleum ether, ether, and chloroform. The molecular structure of hydroxytyrosol is created by replacing the hydrogen atom on the methyl group of ethanol with catechol. It possesses an alcohol hydroxyl group in the chain of ethanol with a benzene ring, along with phenolic hydroxyl groups like other phenolic substances. Its antioxidant activity is closely linked to its structure.

Charakteristisch

Hydroxytyrosol displays much more effective antioxidant characteristics, such as the scavenging of free radicals, breaking peroxidative chain reactions, preventing lipid peroxidation, inhibiting hypochlorous acid derived radicals, and so on, compared with other phenolic compounds in olive oil. It could be used in the dermocosmetic industry for the creation of products for protecting the skin from oxidative stress or used as a preservative in the food technology.

Definition

ChEBI: Hydroxytyrosol is a member of the class of catechols that is benzene-1,2-diol substituted by a 2-hydroxyethyl group at position 4. Isolated from Olea europaea, it exhibits antioxidant and antineoplastic activities. It has a role as a metabolite, an antioxidant and an antineoplastic agent. It is a member of catechols and a primary alcohol. It derives from a 2-(4-hydroxyphenyl)ethanol.

Allgemeine Beschreibung

Hydroxytyrosol, found in olives, is a potent antioxidant in our bodies. It is considered one of the most powerful antioxidants, with an oxygen radical absorption capacity of about 4,500,000 μmolTE/100g. This is 10 times greater than green tea and more than double the antioxidant capacity of CoQ10 and oak extract. Hydroxytyrosol is used in cardiovascular drugs, and has miraculous effects on the prevention and treatment of arteriosclerosis, hypertension, heart disease, cerebral hemorrhage, etc., and is superior to similar drugs. It can also Inhibits the proliferation rate of cancer cells and induces apoptosis of cancer cells.

Biologische Aktivit?t

Hydroxytyrosol is a phenolic component of olive oil that inhibits both 12- and 5-LO. The IC50 values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.2 and 13 μM, respectively. It does not inhibit, and may actually enhance, COX activity. Hydroxytyrosol also protects LDL from both biological and chemical oxidation, suggesting a potential mechanism for the protective effects of olive oil against atherosclerosis.

Mechanism of action

Hydroxytyrosol (3,4-dihydroxyphenylethanol, HTyr), a phenolic alcohol, has been hypothesized to exert a wide range of biological effects, cardioprotective, anticancer, neuroprotective antimicrobial, beneficial endocrine, and other effects. Initially, the wide variety of HTyr biological activities was associated with its potent antioxidant activity. HTyr acts as a free radical scavenger and metal chelator. The high antioxidant efficiency of HTyr is attributed to the presence of the o-dihydroxyphenyl moiety. It mainly acts as a chain breaker by donating a hydrogen atom to peroxyl-radicals (ROO*). In this way, fairly reactive ROO* is replaced with HTyr* radical, unreactive due to intramolecular hydrogen bonds in the phenoxy radical. However, it has been proposed that HTyr may confer additional antioxidant protection by increasing the endogenous defense systems against oxidative stress by activating different cellular signaling pathways. One proposed mechanism involves the HTyr-mediated induction of phase II detoxifying enzymes via nuclear factor E2-related factor 2 (Nrf2) activation in different tissues.

Nebenwirkungen

Hydroxytyrosol (HTyr) is a phenolic alcohol considered by the nutraceutical and food industries to be an excellent food supplement with no known adverse effects.The no observed adverse effect level for HTyr is 50 mg/kg body weight per day. The EFSA Panel on Nutritional Products, Nutrition and Allergies (NDA) on the safety of hydroxytyrosol as a novel food concluded that the MoE at the intended use and use level is adequate for the target population. The Panel concluded that the novel food hydroxytyrosol was safe at the proposed use and use levels.

Hydroxytyrosol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Hydroxytyrosol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 590)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953
sales@pioneerbiotech.com China 3000 58
Nanjing Shunxiang Pharmaceutical Technology Co.,Ltd.
+86-86-02586819868 +8613913839793
sales@jinchemical.com China 23 58
BINBO BIOLOGICAL CO.,LTD
+8618629063126
info@binbobiological.com China 346 58
SUZHOU NMT BIOTECH CO.,LTD
+86-0512-62388427 +86-17306196472
nmtdianzi@163.com China 41 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12829 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5893 58
Hebei Kingfiner Technology Development Co.Ltd
+86-15532196582 +86-15373005021
lisa@kingfinertech.com China 2990 58
Wuhan Haorong Biotechnology Co.,ltd
+86-18565342920; +8618565342920
sales@chembj.net China 289 58
Chongqing Zhihe Biopharmaceutical Co., Ltd.
+8618580541567
sales@zhswyy.com China 303 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 3002 58

10597-60-1()Verwandte Suche:


  • 3,4-DIHYDROXYPHENYLETHANOL
  • 4-(2-HYDROXYETHYL)-1,2-BENZENEDIOL
  • 2-(3,4-DIHYDROXYPHENYL)ETHYL ALCOHOL
  • BA2774
  • 3,4-Dihydroxybenzeneethanol
  • 1,2-Benzenediol, 4-(2-hydroxyethyl)-
  • beta-3,4-Dihydroxyphenylethyl alcohol
  • 2-(3,4-Dihydroxyphenyl)ethal
  • 3,4-Dihydroxyphenylethyl alcohol ,98%
  • Hydroxy Tyrosol (>85%)
  • HoMoprotocatechuyl Alcohol
  • 3,4-Dihydroxyphenethyl Alcohol 2-(3,4-Dihydroxyphenyl)ethanol
  • The hydroxytyrosol
  • olive/Olive leaf Extract/Hydroxytyrosol
  • 3,4-Dihydroxyphenylethanol (antioxidant)
  • NanoLiposomal Hydroxytyrosol
  • 3,4-Dihydrozyphenylethanol
  • 3,4-Dihydroxyphenylethano
  • 2-(3;4-DIHYDROXYPHENYL)ETHYL ALCOHOL;3-HYDROXYTYROSOL
  • 4-Dihydroxyphenyl)ethyl alcohol
  • 3-Hydroxytyrosol - Technical
  • Hydroxytyrosol 3-20%
  • 2-(3,4-Dihydroxyphenyl)ethylAlcohol>
  • Hydroxytyroso
  • hydroxytyrosol, 3,4-dihydroxyphenylethanol
  • CAS: 10597-60-1 3-Hydroxytyrosol 99% Min by HPLC
  • 3-Hydroxytyrisol
  • Hydroxytyrosol Powder
  • 3,4-DIHYDROXYPHENETHYL ALCOHOL
  • 3,4-DIHYDROXYPHENYLETHYL ALCOHOL
  • 3-HYDROXYTYROSOL
  • 2-(3,4-DIHYDROXYPHENYL)ETHANOL
  • 4-(2-hydroxyethyl)benzene-1,2-diol
  • Dopet
  • Dihydroxyphenylethanol
  • (S)-2-amino-3-(4-hydroxyphenyl)propane-1,1-diol
  • Dopaol
  • Olive Leaf Extract Hydroxytyrosol
  • Top quality exporter Hydroxytyrosol(99%,fermented) Competitive price 10597-60-1
  • Hydroxytyrosol ( DOPET)
  • Hydroxytyrosol / 3,4-Dihydrozyphenylethanol
  • Natural Supplement Olive Leaf Extract Pure Hydroxytyrosol Powder
  • Hydroxytyrosol Plant Extraction Cosmetic ingredients 99%
  • Hydroxytyrosol Plant Extraction Cosmetic ingredients
  • 3,4-Dihydroxypheny1
  • Water Soluble Olive Leaf Extract Hydroxytyrosol
  • HYDROXYTYROSOL
  • Hydroxytyrosol-RM
  • 10597-60-1
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Phenoxyacetic Acids and Alcohols (substituted)
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