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Acetohydroxamsure

Acetohydroxamic acid Struktur
546-88-3
CAS-Nr.
546-88-3
Bezeichnung:
Acetohydroxamsure
Englisch Name:
Acetohydroxamic acid
Synonyma:
AHA;N-HYDROXYACETAMIDE;Acetylhydroxamic acid;Acetomenadione;Acetylhydroxylamine;T-41B;NSC 5073;Lithostat;NSC 176136;NSC 408425
CBNumber:
CB6395344
Summenformel:
C2H5NO2
Molgewicht:
75.07
MOL-Datei:
546-88-3.mol

Acetohydroxamsure Eigenschaften

Schmelzpunkt:
88-90 °C (lit.)
Siedepunkt:
133.7°C (rough estimate)
Dichte
1.2269 (rough estimate)
Brechungsindex
1.4264 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
L?slichkeit
Methanol (Sparingly), Water (Sparingly)
Aggregatzustand
Crystalline Solid
pka
8.70(at 25℃)
Farbe
White to pale yellow
Wasserl?slichkeit
Soluble in water.
Sensitive 
Hygroscopic
Merck 
14,63
BRN 
1739019
Stabilit?t:
Moisture and Temperature Sensitive
InChIKey
RRUDCFGSUDOHDG-UHFFFAOYSA-N
CAS Datenbank
546-88-3(CAS DataBase Reference)
NIST chemische Informationen
Acetamide,N-hydroxy(546-88-3)
EPA chemische Informationen
Acetohydroxamic acid (546-88-3)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 61-40
S-S?tze: 53-45-36/37/39-22
RIDADR  3263
WGK Germany  3
RTECS-Nr. AK8157000
Hazard Note  Toxic
PackingGroup  II
HS Code  29225090
Giftige Stoffe Daten 546-88-3(Hazardous Substances Data)
Toxizit?t mmo-sat 160 mmol/plate JOPHDQ 3,557,80
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H360 Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Acetohydroxamsure Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R61:Kann das Kind im Mutterleib sch?digen.
R40:Verdacht auf krebserzeugende Wirkung.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.

Beschreibung

Acetohydroxamic acid is a potent, non-competitive and irreversible inhibitor of bacterial urease (Ki≈lO-7M). This enzyme, which is widely distributed in plants and bacteria, but not in mammalian cells, catalyzes the decomposition of urea to ammonia. Elevated urinary ammonia levels can reduce the antibacterial effectiveness of a number of agents. Thus, acetohydroxamic acid is useful as adjunctive therapy to decrease urinary ammonia and alkalinity in patients with chronic urea-splitting urinary infection. Such infections are a leading cause of recurring complications and death in paraplegics.

Chemische Eigenschaften

White Crystalline Solid

Verwenden

Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels. 2-Acetohydroxamic acid loaded floating microspheres forms an efficient drug delivery system for the treatment of Helicobacter pylori.
Acetohydroxamic acid was used:
to study the mechanism of complexation of iron (III) with acetohydroxamic acid.
to study the inhibitory mechanism of lansoprazole and omeprazole on Helicobacter pyloni.
in urease inhibition studies.
for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile.
Used in urease inhibition studies and for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile.

Allgemeine Beschreibung

Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels. 2-Acetohydroxamic acid loaded floating microspheres forms an efficient drug delivery system for the treatment of Helicobacter pylori.

Nebenwirkungen

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
pounding heartbeats or fluttering in your chest;
signs of a blood clot in your leg --pain, swelling, warmth, or redness in one or both legs;
signs of a red blood cell disorder --pale or yellowed skin, dark colored urine, fever, confusion or weakness.
Common side effects may include:
headache during the first 2 days of treatment;
skin rash, warmth, tingling or redness (especially if you drink alcohol while taking acetohydroxamic acid);
upset stomach, nausea, loss of appetite;
depressed mood;
anxiety, tremors, nervousness;
hair loss.

Sicherheitsprofil

Moderately toxic by intraperitonealroute. An experimental teratogen. Other experimentalreproductive effects. Mutation data reported. When heatedto decomposition it emits toxic fumes of NOx.

Acetohydroxamsure Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Acetohydroxamsure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 529)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18151 58
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+8613343047651
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+86-371-66670886
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Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Shanxi Naipu Import and Export Co.,Ltd
+86-13734021967 +8613734021967
kaia@neputrading.com China 1001 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58

546-88-3(Acetohydroxamsure)Verwandte Suche:


  • cetohyroxamic acid
  • Hydroxylamine, N-Acetyl-
  • Hydroxylamine,N-acetyl-
  • Lithostat
  • Methylhydroxamic acid
  • methylhydroxamicacid
  • n-acetyl-hydroxylamin
  • n-hydroxy-acetamid
  • N-ACETYLHYDROXYLAMINE
  • AcetohydroxaMic acid 98%
  • AcetohydroxaMic acid, 95+%
  • ALA-HIS-ALA
  • Acetohydroxamic acid, N-Acetylhydroxylamine
  • Acetohydroxamic Acid (200 mg)
  • AcetohydroxaMic acid, 98+% 5GR
  • NSC 176136
  • NSC 408425
  • NSC 5073
  • ACETYL HYDROXYAMINE
  • ACETOHYDROXAMIC ACID
  • AcetohydroxamicAcid[Aha]Urostat/LithostatC2H5No2
  • Acetohydroxamicacid,98%
  • Acetohydroxamic
  • Acetamide,N-hydroxy-
  • acethydroxamsaeure
  • Acethydroxamsaure
  • Acetic acid, oxime
  • aceticacid,oxime
  • acetohydroxamicacid(INN)
  • Acetohydroxamsαure
  • Acetohydroximic acid
  • acetohydroximicacid
  • Acetyl hydroxyamino
  • acetylhydroxamicacid
  • N-hydroxyacetimidic acid
  • yangwosuan
  • Acetohydroxamic Acid >
  • Acetamide, N-hydroxy- (9CI)
  • acetohydroxmic acid
  • Acetohydroxamic acid USP/EP/BP
  • Acetohydroxamic Acid (1006506)
  • Acetylhydroxylamine
  • AHA
  • N-HYDROXYACETAMIDE
  • Acetomenadione
  • Acetylhydroxamic acid
  • Vinegar acid hydroxylamine
  • Acetoxyoxime acid
  • Acetohydroxamic Acid,Acetomenadione
  • Acetohydroxamic acid (6CI, 8CI)
  • Acetoxoxime acid
  • N-hydroxyacetamide / Acetohydroxamic acid
  • Acetoxyxamic acid
  • Acetohydroxamic Acid, ≥ 95.0%
  • T-41B
  • 546-88-3
  • Organic Building Blocks
  • Nitrogen Compounds
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