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(6R-trans)-7-[2-(2-Aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsuredihydrochlorid

Cefotiam hydrochloride Struktur
66309-69-1
CAS-Nr.
66309-69-1
Bezeichnung:
(6R-trans)-7-[2-(2-Aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsuredihydrochlorid
Englisch Name:
Cefotiam hydrochloride
Synonyma:
CEFOTIAM 2HCL;Spizef;Ceftiam;Halospor;Sporidyn;Pansporin;Cefapicol;Pansporine;Kemisporin;Sepidnarin
CBNumber:
CB6386641
Summenformel:
C18H23N9O4S3.HCl
Molgewicht:
562.08
MOL-Datei:
66309-69-1.mol

(6R-trans)-7-[2-(2-Aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsuredihydrochlorid Eigenschaften

Schmelzpunkt:
>93°C (dec.)
Siedepunkt:
94℃
RTECS-Nr.
XI0367000
Flammpunkt:
>110°(230°F)
storage temp. 
Inert atmosphere,2-8°C
L?slichkeit
H2O: ≥22M
Aggregatzustand
powder
Farbe
white to tan
Wasserl?slichkeit
Soluble in water
Stabilit?t:
Hygroscopic
InChIKey
BWRRTAXZCKVRON-DGPOFWGLSA-N
CAS Datenbank
66309-69-1(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36
S-S?tze: 26
WGK Germany  3
HS Code  2941906000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

(6R-trans)-7-[2-(2-Aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsuredihydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Cefotiam was synthesized by Takeda Chemicals Industries in 1977 as the first cephem derivative to introduce the aminothiazol group in the 7 side chain and the alkylated tetrazole group at the 3 side chain . This drug shows greater antibacterial activity against gram-negative bacteria than the earlier cephalosporins, including Enterobacter, Citrobacter, and indole-positive Proteus, and it retains the same activity as they have against gram-positive organisms. Its excellent activity against Klebsiella and Escherichia coli is based on its ability to penetrate the cell. This is 3- to 70-fold greater than that of cephalothin or cefazolin.

Definition

ChEBI: Cefotiam dihydrochloride is the dihydrochloride salt of cefotiam. It has a role as an antibacterial drug. It contains a cefotiam.

Trademarks

Ceradon (Takeda).

(6R-trans)-7-[2-(2-Aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsuredihydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(6R-trans)-7-[2-(2-Aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsuredihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 286)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21634 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479
sales@fine-chemtech.com CHINA 885 55
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29880 58
Shaanxi Yikanglong Biotechnology Co., Ltd. 		17791478691
yklbiotech@163.com CHINA 296 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28172 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49374 58
SIMAGCHEM CORP 		+86-13806087780
 sale@simagchem.com China 17365 58
Hebei Runbin Biotechnology Co. LTD 		13180553332
 2179877681@qq.com CHINA 990 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58

66309-69-1((6R-trans)-7-[2-(2-Aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsuredihydrochlorid)Verwandte Suche:

  • cefotiam hydrochloride
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R,7R)-
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-, dihydrochloride, (6R-trans)-
  • Abbott 48999
  • Halospor
  • Pansporin
  • Pansporine
  • Spizef
  • Sporidyn
  • Cefotiam Hydrochloride (350 mg)
  • (6R,7R)-7-[2-(2-aMino-1,3-thiazol-4-yl)acetaMido]-3-[({1-[2-(diMethylaMino)ethyl]-1H-1,2,3,4-tetrazol-5-yl}sulfanyl)Methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6r-trans)-7-[2-(2-aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1h-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
  • Cefapicol
  • Kemisporin
  • Sepidnarin
  • (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-(2-dimethylaminoethyl)tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride
  • (6R,7R)-7-[[2-(2-aminothiazol-4-yl)acetyl]amino]-3-[[[1-(2-dimethylaminoethyl)tetrazol-5-yl]thio]methyl]-8-keto-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride
  • (6R,7R)-7-[2-(2-azanyl-1,3-thiazol-4-yl)ethanoylamino]-3-[[1-(2-dimethylaminoethyl)-1,2,3,4-tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride
  • Cefotiam Hydrochloride (325 mg)
  • cefotiamdihydrochloride
  • dihydrochloride,(6r-trans)--oxo
  • (6R,7R)-7-[[2-(2-AMino-4-thiazolyl)acetyl]aMino]-3-[[[1-[2-(diMethylaMino)ethyl]-1H-tetrazol-5-yl]thio]Methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Hydrochloride
  • 20MG/100MG/KG
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[2-(2-aMino-4-thiazolyl)acetyl]aMino]-3-[[[1-[2-(diMethylaMino)ethyl]-1H-tetrazol-5-yl]thio]Methyl]-8-oxo-,hydrochloride (1:2), (6R,7R)-
  • (6R,7R)-7-[[2-(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]-thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride hydrate
  • Cefotiam dihydrochloride hydrate
  • Ceftiam
  • cefotian Hydrochloride
  • Cefotiam DiHCl
  • 7-[[2-(2-amino-4-thiazolyl)-1-oxoethyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-5-tetrazolyl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
  • Cefotiam Dihydrochloride(Crude)
  • SCE-963 hydrochloride
  • (6R,7R)-7-(2-(2-Aminothiazol-4-yl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride
  • Cefotiam hydrochloride USP/EP/BP
  • (6R-trans)-7-[2-(2-Aminothiazol-4-yl)acetamido]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsuredihydrochlorid
  • Cefotiam hydrochloride Impurities
  • Cefotiam Hydrochloride (1098005)
  • CEFOTIAM 2HCL
  • Cefotiame hydrochloride
  • 66309-69-1
  • 6309-69-1
  • 66309-69-01
  • C18H23N9O4S3
  • C18H23N9O4S3HCl
  • C18H23N9O4S32HCl
  • C18H24ClN9O4S3
  • C18H25Cl2N9O4S3
  • 59855
  • ANTRYPOL
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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