(S)-3-Hydroxy-gamma-butyrolactone
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- CAS-Nr.
- 7331-52-4
- Englisch Name:
- (S)-3-Hydroxy-gamma-butyrolactone
- Synonyma:
- (S)-4-Hydroxydihydrofuran-2(3H)-one;(s)-(-)-á-hydroxy-;-4-Hydroxydihydrofuran-2(3H);(S)-(-)-3-HYDROXYBUTYROLACTONE;(S)-(-)-3-HYDROXY-GAMMA-BUTYROLACTONE;2(3H)-FURANONE, DIHYDRO-3-HYDROXY-, (S);2(3H)-FURANONE, DIHYDRO-4-HYDROXY-, (S);(S)-3-Hydroxy-gamma-;Levetiracetam Impurity 65;(S)-3-HYDROXYBUTYROLACTONE
- CBNumber:
- CB6360496
- Summenformel:
- C4H6O3
- Molgewicht:
- 102.09
- MOL-Datei:
- 7331-52-4.mol
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(S)-3-Hydroxy-gamma-butyrolactone Eigenschaften
- Siedepunkt:
- 98-100 °C0.3 mm Hg(lit.)
- Dichte
- 1.241 g/mL at 25 °C(lit.)
- Brechungsindex
- n20/D 1.464(lit.)
- Flammpunkt:
- >230 °F
- storage temp.
- Inert atmosphere,2-8°C
- pka
- 12.87±0.20(Predicted)
- Optische Aktivit?t
- [α]21/D 81°, c = 2 in ethanol
- Wasserl?slichkeit
- Miscible with water, alcohol and other organic solvent. Immiscible with light petroleum.
- BRN
- 1280864
- InChI
- InChI=1S/C4H6O3/c5-3-1-4(6)7-2-3/h3,5H,1-2H2/t3-/m0/s1
- InChIKey
- FUDDLSHBRSNCBV-VKHMYHEASA-N
- SMILES
- O1C[C@@H](O)CC1=O
- CAS Datenbank
- 7331-52-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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(S)-3-Hydroxy-gamma-butyrolactone Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Colorless to light yellow liquid.
Verwenden
(S)-3-Hydroxy-γ-butyrolactone can be used as an anticancer drug resistance inhibitor.
Application
(S)-3-Hydroxy-gamma-butyrolactone is an important synthetic intermediate for a variety of chiral compounds. It is a key intermediate for preparing neuromediator (R)-GABOB, l-carnitine, and HMG-CoA reductase inhibitor, CI-981. (S)-3-Hydroxy-gamma-butyrolactone has been reported as a satiety and potentiating agent to neuroleptic drugs. It is widely used in the pharmaceutical industry as a chiral building block for the statin class of cholesterol-reducing drugs such as Crestor and Lipitor, as well as the antibiotic Zyvox and the antihyperlipidemic medication Zetia. Other pharmaceuticals derived from 3HBL include HIV inhibitors and the nutritional supplement L-carnitine. 3HBL can readily be transformed into a variety of three-carbon building blocks and has been listed as one of the top value-added chemicals from biomass by the US Department of Energy[1-2].
(S)-3-Hydroxy-gamma-butyrolactone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(S)-3-Hydroxy-gamma-butyrolactone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 373)Lieferanten
7331-52-4()Verwandte Suche:
- (S)-(-)-3-HYDROXY-GAMA-BUTYROLACTONE
- (S)-3-HYDROXY-GAMMA-BUTYROLACTONE
- (S)-(-)-BETA-HYDROXY-GAMMA-BUTYROLACTONE
- (S)-BETA-HYDROXY-GAMMA-BUTYROLACTONE
- (S)-(-)-BETA-HYDROXY-GAMMA-BUTYROLACTONE , EE 99%
- (S)-(-)-SS-HYDROXY-GAMMA-BUTYROLACTONE: 94%
- (S)-(-)--HYDROXY-G-BUTYROLACTONE
- 4(S)-Hydroxytetrahydrofuran-2-ONE
- (S)-(-)-b-Hydroxy-g-butyrolactone
- (S)-DIHYDRO-4-HYDROXY-2(3H)-FURANONE
- (S)-(-)-~-Hydroxy-gamma-butyrolactone, 97%, ee 99%
- (S)-(-)-^b-Hydroxy-^y-butyrolactone, 97%, ee 99%
- (S)-(-)-β-Hydroxy-γ-butyrolactone, 97%, ee 99%
- (S)-(-)-^b-Hydroxy-^y-butyrolactone, 94%
- S-(-)-3-Hydroxy-gammalactone
- (S)-3-Hydroxy-γ-butyrolactone ,98%
- (S)-3-Hydroxy-gamma-
- 2(3H)-Furanone,dihydro-4-hydroxy-, (4S)-
- (S)-beta-Hydroxy-gamma-butyrolactone 96%
- (S)-(-)-3-Hydroxy-g-butyrolactone
- (S)-3-Hydroxy-gamma-butyrolactone,97%
- (S)-(-)-beta-Hydroxy-gamma-butyrolactone, 97%, ee 99%
- (S)-4-HYDROXYTETRAHYDROFURAN-2-ONE
- (S)-4,5-DIHYDRO-4-HYDROXY-2(3H)-FURANONE
- (S)-3-HYDROXYBUTYROLACTONE
- (S)-3-Hydroxy-γ-butyrolactone>
- (4S)-4-Hydroxytetrahydrofuran-2-one
- (S)-β-Hydroxy-γ-butyrolactone
- Tetramethylene Glycol powder
- S)-3-Hydroxy-gamma-butyrolactttone
- (S)-(-)-3-HYDROXY-GAMMA-BUTYROLACTONE
- (s)-(-)-á-hydroxy-
- (S)-4-Hydroxydihydrofuran-2(3H)-one
- -4-Hydroxydihydrofuran-2(3H)
- 2(3H)-FURANONE, DIHYDRO-3-HYDROXY-, (S)
- 2(3H)-FURANONE, DIHYDRO-4-HYDROXY-, (S)
- (S)-(-)-3-HYDROXYBUTYROLACTONE
- (S)-3-Hydroxyl group-gamma-Butyl lactone
- (S)-3-Hydroxy-gamma-butyrolactone 7331-52-4
- (S)-3-Hydroxy-gamma-butyroctone
- Levetiracetam Impurity 65
- Phenyl Acetate Impurity 61
- (S)-β-Hydroxy-γ-butyrolactone
- 7331-52-4
- 73311-52-4
- Asymmetric Synthesis
- Chiral Building Blocks
- Simple Alcohols (Chiral)
- Lactones
- Organic Building Blocks
- Chiral Building Blocks
- Simple Alcohols (Chiral)
- Synthetic Organic Chemistry
- Tetrahydrofuran Series
- chiral
- 7331-52-4
