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1-Methyl-2-(2,6-xylyloxy)ethylammoniumchlorid

Mexiletine hydrochloride  Struktur
5370-01-4
CAS-Nr.
5370-01-4
Bezeichnung:
1-Methyl-2-(2,6-xylyloxy)ethylammoniumchlorid
Englisch Name:
Mexiletine hydrochloride
Synonyma:
Toy;Katen;ko1173;Olzoron;mexitil;Ritalmex;Ko 1173Cl;Mexilitene;Cirumimeru;N-(3-Cyano-4
CBNumber:
CB6114224
Summenformel:
C11H18ClNO
Molgewicht:
215.72
MOL-Datei:
5370-01-4.mol

1-Methyl-2-(2,6-xylyloxy)ethylammoniumchlorid Eigenschaften

Schmelzpunkt:
200-203°C
Dichte
1.12 g/cm3
storage temp. 
2-8°C
L?slichkeit
ethanol: 50 mg/mL
Aggregatzustand
powder
pka
9.0(at 25℃)
Farbe
white
maximale Wellenl?nge (λmax)
272nm(MeOH)(lit.)
Merck 
14,6169
Stabilit?t:
Hygroscopic
CAS Datenbank
5370-01-4(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 20/21/22-36/37/38-22
S-S?tze: 36-26
WGK Germany  3
RTECS-Nr. KR9300000
HS Code  2922190900
Toxizit?t LD50 in male, female rats, mice, rabbits (mg/kg): 350, 400, 310, 400, 180, 160 orally; in male, female rats, mice (mg/kg): 27, 30, 43, 50 i.v. (Kast)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit

1-Methyl-2-(2,6-xylyloxy)ethylammoniumchlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitssch?dlich beim Verschlucken.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED50 values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or inhibits conduction across the Purkinje fiber-muscle junction, shortens action potential duration, and decreases the refractory period when used at concentrations less than 5 μg/ml in isolated canine Purkinje fiber and ventricular muscle preparations.

Chemische Eigenschaften

White to Off-White Solid

Verwenden

Mexiletine hydrochloride has been used as a sodium channel blocker:
  • expressed in chinese hamster ovary cells
  • in human embryonic kidney (HEK) cells for whole cell patch-clamp studies
  • electrophysiology studies in HEK cells expressing Nav1.7 protein

Definition

ChEBI: A hydrochloride composed of equimolar amounts of mexiletine and hydrogen chloride.

Allgemeine Beschreibung

Mexiletine hydrochloride,1-methyl-2-(2,6-xylyloxy)ethylamine hydrochloride (Mexitil)(pKa 8.4), is a class IB antiarrhythmic agent that is effectivewhen given either intravenously or orally. It resembles lidocainein possessing a xylyl moiety but otherwise is differentchemically. Mexiletine hydrochloride is an ether and is notsubject to the hydrolysis common to the amides lidocaineand tocainide. Its mean half-life on oral administration isapproximately 10 hours.
Although not subject to hydrolysis, mexiletine hydrochlorideis metabolized by oxidative and reductiveprocesses in the liver. Its metabolites, p-hydroxymexiletineand hydroxymethylmexiletine, are not pharmacologicallyactive as antiarrhythmic agents.

Biologische Aktivit?t

Use-dependent sodium channel blocker (IC 50 values are 75.3 and 23.6 μ M for tonic and use-dependent block respectively). Class Ib antiarrhythmic, neuroprotective and antimyotonic agent.

Clinical Use

Mexiletine hydrochloride, like class I antiarrhythmicagents, blocks the fast Na channel in cardiac cells. It isespecially effective on the Purkinje fibers in the heart. Thedrug increases the threshold of excitability of myocardialcells by reducing the rate of rise and amplitude of the actionpotential and decreases automaticity.
Mexiletine hydrochloride is used for long-term oral prophylaxisof ventricular tachycardia. The drug is given in200- to 400-mg doses every 8 hours.

1-Methyl-2-(2,6-xylyloxy)ethylammoniumchlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


1-Methyl-2-(2,6-xylyloxy)ethylammoniumchlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 264)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118
xie@china-sinoway.com China 988 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +8618949832763
info@tnjchem.com China 2986 55
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569262 +86-15319487004
1015@dideu.com China 3209 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10319 58
Longyan Tianhua Biological Technology Co., Ltd
0086 18039857276 18039857276
CHINA 2783 58

5370-01-4(1-Methyl-2-(2,6-xylyloxy)ethylammoniumchlorid)Verwandte Suche:


  • 1-(2,6-dimethylphenoxy)-2-aminopropanehydrochloride
  • 1-(2,6-dimethylphenoxy)-2-propanaminhydrochloride
  • Ko 1173Cl
  • Mexilitene
  • 1-(2,6-DIMETHYLPHENOXY)-2-PROPANANMINE HYDROCHLORIDE
  • MEXILETIN HYDROCHLORIDE
  • 2-Propanamine, 1-(2,6-dimethylphenoxy)-, hydrochloride (9CI)
  • Ethylamine, 1-methyl-2-(2,6-xylyloxy)-, hydrochloride (7CI, 8CI)
  • TIMTEC-BB SBB003392
  • 1-Methyl-2-(2,6-xyloxy)ethylamine hydrochloride
  • Katen
  • Ritalmex
  • Cirumimeru
  • Olzoron
  • Toy
  • Mexiletine Hydrochloride (200 mg)
  • 1-(2,6-Dimethylphenoxy)-2-propylamine Hydrochloride
  • 2-Propanamine, 1-(2,6-dimethylphenoxy)-, hydrochloride (1:1)
  • 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride 97%
  • 1-methyl-2-(2,6-xylyloxy)-ethylaminehydrochloride
  • 1-methyl-2-(2,6-xylyloxy)-ethylaminhydrochloride
  • ko1173
  • koe1173hydrochloride
  • mexitil
  • MEXILETINE HYDROCHLORIDE
  • MEXILITINE HCL
  • 1-(2,6-DIMETHYLPHENOXY)-2-PROPANAMIDE HYDROCHLORIDE
  • 1-(2,6-DIMETHYLPHENOXY)-2-PROPANAMINE HYDROCHLORIDE
  • 1-(2,6-XYLYLOXY)-2-AMINOPROPANE HYDROCHLORIDE SALT
  • [(2R)-1-(2,6-dimethylphenoxy)propan-2-yl]ammonium
  • Mexiletine Hydrochloride EP Impurity D
  • 1-(2,6-Dimethylphenoxy)-2-propanamine HCl
  • Mexiletine hydrochloride CRS
  • MexiletineHydrochloride>
  • Mexiletine Hydrochloride RS
  • Mexiletine-d3 HCl
  • 1-(2,6-Dimethylphenoxy)propan-2-amine hydrochloride
  • Mexiletine hydrochloride USP/EP/BP
  • Mexiletine HCl (KOE-1173)
  • Mexiletine HydrochlorideQ: What is Mexiletine Hydrochloride Q: What is the CAS Number of Mexiletine Hydrochloride Q: What is the storage condition of Mexiletine Hydrochloride Q: What are the applications of Mexiletine Hydrochloride
  • Mexiletine Hydrochloride (1443250)
  • 7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
  • N-(3-Cyano-4
  • Mexiletine hydrochioride
  • Mexiletine Hydrochloride, ≥ 98.0%
  • Mexiline hydrochloride
  • 5370-01-4
  • 5370-1-4
  • 5370-10-4
  • C11H17NOHCl
  • CH32C6H3OCH2CHCH3NH2HCl
  • Organic Building Blocks
  • Nitrogen Compounds
  • Amine Salts
  • Building Blocks
  • TRILAFON
  • Cardiovascular APIs
  • Amines
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