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Levocetirizine

Levocetirizine Struktur
130018-77-8
CAS-Nr.
130018-77-8
Englisch Name:
Levocetirizine
Synonyma:
LEVOCETRIZINE;(R)-2-[2-[4-(4-chlorophenyl)-phenylmethyl]-phenylmethyl-1-]-piperazinyl-]ethoxyl﹞acetic acid dihydrochloride;alerlisin;Cetirizine-d4;LEVOCETIRIZINE;(R)-Cetirizine;Levocetirizine-d4;(R)-Cetirizine-d4;Cetirizine R-Isomer;Levocetirizine-IP/IHS
CBNumber:
CB5712207
Summenformel:
C21H25ClN2O3
Molgewicht:
388.89
MOL-Datei:
130018-77-8.mol

Levocetirizine Eigenschaften

Schmelzpunkt:
205-208°C (dec.)
Siedepunkt:
542.1±45.0 °C(Predicted)
Dichte
1.237±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
L?slichkeit
DMSO: 78 mg/mL (200.57 mM);Ethanol: 78 mg/mL (200.57 mM)
pka
3.46±0.10(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white
Wasserl?slichkeit
Water: 78 mg/mL (200.57 mM)
BCS Class
3
CAS Datenbank
130018-77-8(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  29335990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Levocetirizine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The (R)-enantiomer of the second-generation antihistamine cetirizine, levocetirizine, was first introduced in Germany for seasonal allergic rhinitis (including ocular symptoms), perennial allergic rhinitis and chronic idiopathic urticaria. The dihydrochloride salt can be prepared in four steps from optically active 4-chlorobenzhydrylamine obtained by resolution of its racemate with (+)-tartaric acid. Levocetirizine (eutomer) is a 2-fold more potent H1 antagonist than cetirizine whereas the other enantiomer (distomer) is 10-fold less potent compared to levocetirizine. Pharmacodynamic studies on healthy volunteers showed that compared to cetirizine, half the dose of levocetirizine (5 mg) was necessary to obtain similar inhibitory effects in the skin test of histamine-induced wheal and flare as well as on histamine-induced nasal congestion and nasal resistance. There was no evidence of chiral inversion of levocetirizine in vivo in several species including human. The daily dose of drug is rapidly and extensively absorbed in human. Interestingly, its volume of distribution (0.41 kg/L) is smaller than that of the distomer (0.60 kg/L). The low volume of distribution is considered as favorable for an antihistamine both in terms of efficacy and safety. Due to its high metabolic stability and lack of effect on the activities of the major CYP isoenzymes, levocetirizine is unlikely to cause interactions with other administered drugs. No clinically relevant effect on electrocardiograms of healthy volunteers was detected.

Chemische Eigenschaften

Off-White Solid

Verwenden

A nonsedating type histamine H1-receptor antagonist. A major metabolite of Hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. Antihystaminic.

Levocetirizine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Levocetirizine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 167)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14332 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29815 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 31991 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
Shijiazhuang Gantuo Biotechnology Co., Ltd
+8613373514458
gantuo02@cngantuo.com China 203 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
+86-029-86333380 18829239519
sales06@tgybio.com China 903 58

130018-77-8()Verwandte Suche:


  • LEVOCETIRIZINE
  • alerlisin
  • LevocetirizineHydrochloride
  • 2-[2-[4-[(4-Chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid
  • Cetirizine-d4
  • Levocetirizine-d4
  • (R)-Cetirizine
  • (R)-Cetirizine Dihydrochloride
  • 2-[2-[4-[(R)-(4-Chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]acetic Acid Dihydrochloride
  • (R)-Cetirizine-d4
  • -2-(2-(4-((4-Chlorophenyl)
  • Cetirizine R-Isomer
  • 2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]-1-piperazinyl]ethoxy]acetic acid
  • Cetirizine Impurity 20
  • (R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic acid
  • Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
  • Levoce/0/2/7/5/9/8/4/7/2/5/5/-tirizine
  • Levocetirizine-IP/IHS
  • LevocetirizineQ: What is Levocetirizine Q: What is the CAS Number of Levocetirizine Q: What is the storage condition of Levocetirizine
  • LEVOCETRIZINE
  • (R)-2-[2-[4-(4-chlorophenyl)-phenylmethyl]-phenylmethyl-1-]-piperazinyl-]ethoxyl﹞acetic acid dihydrochloride
  • Benodanil Impurity 17 (Pyracarbolid)
  • Levocetirizine Hydrochloride IP / USP
  • Levocetirizine (R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1- yl)ethoxy)acetic acid
  • LevocetirizineDihydrochloride(USP)
  • 130018-77-8
  • C21H21ClN2O3D4
  • C21H25ClN2O3
  • XYZAL
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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