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Famotidine

Famotidine Struktur
76824-35-6
CAS-Nr.
76824-35-6
Englisch Name:
Famotidine
Synonyma:
pepcid;Ifada;ganor;mk208;gaster;motiax;muclox;pepdul;peptan;Amfamox
CBNumber:
CB5706585
Summenformel:
C8H15N7O2S3
Molgewicht:
337.45
MOL-Datei:
76824-35-6.mol

Famotidine Eigenschaften

Schmelzpunkt:
163-164°C
Siedepunkt:
562.7±60.0 °C(Predicted)
Dichte
1.5111 (rough estimate)
Brechungsindex
1.7400 (estimate)
storage temp. 
2-8°C
L?slichkeit
Very slightly soluble in water, freely soluble in glacial acetic acid, very slightly soluble in anhydrous ethanol, practically insoluble in ethyl acetate. It dissolves in dilute mineral acids
pka
pKa 6.76(H2O t=23.0) (Uncertain)
Aggregatzustand
Solid
Farbe
White to Off-White
Wasserl?slichkeit
1.1 mg/mL
BCS Class
3
Stabilit?t:
Light Sensitive
InChI
InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
InChIKey
XUFQPHANEAPEMJ-UHFFFAOYSA-N
SMILES
C(NS(N)(=O)=O)(=N)CCSCC1=CSC(NC(N)=N)=N1
CAS Datenbank
76824-35-6(CAS DataBase Reference)
EPA chemische Informationen
Propanimidamide, 3-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)- (76824-35-6)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 20/21/22-45-61
S-S?tze: 22-24/25-53-45-36/37/39
WGK Germany  2
RTECS-Nr. UA2300000
HS Code  29341000
Giftige Stoffe Daten 76824-35-6(Hazardous Substances Data)
Toxizit?t LD50 i.v. in mice: 244.4 mg/kg (Yasufumi)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
Sicherheit
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P403 An einem gut belüfteten Ort aufbewahren.

Famotidine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R45:Kann Krebs erzeugen.
R61:Kann das Kind im Mutterleib sch?digen.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Beschreibung

Famotidine is a competitive histamine H2-receptor antagonist, and the main pharmacodynamic effect of famotidine is to cause the inhibition of gastric secretion. Famotidine on decomposition releases toxic products such as carbon oxides (CO, CO2), nitrogen oxides (NO, NO2), and sulphur oxides (SO2, SO3). Famotidine is a medication that is available both in prescription and over-the-counter forms. It is used to treat conditions related to the oesophagus, stomach, and intestines. Some specific famotidine is used for the treatment of duodenal ulcers, gastric ulcers (stomach ulcers), gastroesophageal reflux disease (GERD), and pathological hypersecretory conditions that occur when stomach acid is secreted/ produced in very large quantities, an abnormal health condition called ‘Zollinger-Ellison syndrome’.

Chemische Eigenschaften

White Powder

Verwenden

Contact dermatitis from famotidine, a H2 -receptor agonist, was described in a nurse. In industry, three cases were reported due to intermediates of synthesis, 2- diamino-ethylene-amino-thiazolyl-methylenethiourea-dichloride and 4-chloromethyl-2-guanidinothiazolenitrochloride.

Allgemeine Beschreibung

Famotidine is a histamine H2-receptor antagonist, which promotes the healing of erosive esophagitis, gastric and duodenal ulcers since it inhibits the gastric acid secretion in humans.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Kontakt-Allergie

Contact dermatitis in a nurse from famotidine, an H2-receptor agonist, was described. In industry, three cases were reported due to intermediates of the synthesis of 2-diamino-ethylene-amino-thiazolyl-methylenethio urea-dichloride, and 4-chloromethyl-2-guanidinothiaz ole-nitrochloride.

Clinical Use

Famotidine is a histamine H2-antagonist more potent than cimetidine and ranitidine. Administered once or twice daily, it is useful in the treatment of gastric, duodenal and anastomotic ulcers, upper gastrointestinal tract hemorrhage, reflux esophagitis and Zollinger-Ellison syndrome. Like ranitidine, it is lacking in antiandrogenic effects.

Famotidine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Famotidine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 688)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Kangcang new material Technology Co., LTD
+8615713292910
Nancy@kangcang.com.cn China 341 58
Liaoning Pharmaceutical Innovation Co., Ltd
+8616588669988
sales@pipharma.com.cn China 151 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Anhui Ruihan Technology Co., Ltd
+8617756083858
daisy@anhuiruihan.com China 973 58
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 295 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368 +86-18600796368
sales@sjar-tech.com China 456 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Rixing Chemical CO.,LTD
+86-13237129059 -13237129059
sales@rixingchemi.com CHINA 229 55

76824-35-6()Verwandte Suche:


  • FAMOTIDINE
  • [amino-3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]-methyl]thio]propylidene]s
  • 3-(((2-((aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-n-(aminosulfonyl)p
  • 3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)-n(sup2)-sulfamoylp
  • Famotidine USP&BP
  • FAMOTIDINE, IMP. A (EP) AS HYDROCHLORIDE: 3-[[[2-[DIAMINOMETHYLENE)AMINO]THIAZOL-4-YL]METHYL]-SULPHANYL]PROPANIMIDAMIDE HYDROCHLORIDE MM(CRM STANDARD)
  • FAMOTIDINE, IMPURITY C BP STANDARD
  • FAMOTIDINE, IMP. B (EP) AS DIMALONATE: 3,5-[2-[[[2-[(DIAMINOMETHYLENE)AMINO]THIAZOL-4-YL]METHYL]-SULPHANYL]ETHYL]-4H-1,2,4,6-THIATRIAZINE 1,1-DIOXIDE DIMALONATE MM(CRM STANDARD)
  • FAMOTIDINE, IMPURITY B3,5-BIS[2-[[[2-[(DIAMINOMETHYLENE)AMINO] THIAZOL-4-YL]METHYL]THIO]-ETHYL]-4H-1,2,4,6-THIATRIAZINE1,1-DIOXIDE EP STANDARD
  • FAMOTIDINE, IMP. G (PHARMEUROPA): AS MALEATE 3-[[[2-[(DIAMINOMETHYLENE)AMINO]THIAZOL-4-YL]METHYL]SULPHANYL]-N-CYANO-PROPANIMIDAMIDE MALEATE MM(CRM STANDARD)
  • FAMOTIDINE, USP STANDARD
  • FAMOTIDINE, BP STANDARD
  • FAMOTIDINE, SULPHOXIDE MALEATE MM(CRM STANDARD)
  • FAMOTIDINE, IMP. E (PHARMEUROPA): BIS[2-[[2-[(DIAMINOMETHYLENE)AMINO]-THIAZOL-4-YL]METHYL]]-DISULPHIDE MM(CRM STANDARD)
  • FAMOTIDINE, IMP. D (EP): 3-(2-DIAMINOMETHYLENAMINO-1,3-THIAZOL-4-YLMETHYL-SULPHANYL)PROPANAMIDE MM(CRM STANDARD)
  • FAMOTIDINE, MM(CRM STANDARD)
  • FAMOTIDINE, DEGRADATION IMPURITY 2 BP STANDARD
  • FAMOTIDINE, IMP. C (EP): 3-(2-DIAMINOMETHYLENAMINO-1,3-THIAZOL-4-YLMETHYL-SULPHANYL)-N-SULPHAMOYLPROPANAMIDE MM(CRM STANDARD)
  • FAMOTIDINE, IMPURITY A3-[[[2-[(DIAMINOMETHYLENE)AMINO]THIAZOL-4-YL]METHYL]-THIO]PROPANAMIDE EP STANDARD
  • FAMOTIDINE, IMP. F (PHARMEUROPA): 3-(2-DIAMINOMETHYLEN-AMINO-1,3-THIAZOL-4-YLMETHYL-SULPHANYL)PROPIONIC ACID MM(CRM STANDARD)
  • FAMOTIDINE, DEGRADATION IMPURITY 1 BP STANDARD
  • FAMOTIDINE, EP STANDARD
  • FAMOTIDINE ASSAY STANDARD BP(CRM STANDARD)
  • Propanimidamide, 3-2-(aminoiminomethyl)amino-4-thiazolylmethylthio-N-(aminosulfonyl)-
  • FAMOTIDINE,USP
  • 3-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]-N'-sulfamoyl-propanimidamide
  • N'-[AMINOSULFONYL]-3-[(2-[DIAMINOMETHYLENEAMINO]-4-THIAZOLYL)METHYLTHIO]-PROPANAMIDINE
  • Famotidine (Patented-No Supply)
  • [1-Amino-3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]propylidene]sulfamide
  • 2-[4-[2-(amino-sulfamoylimino-methyl)ethylsulfanylmethyl]-1,3-thiazol-2-yl]guanidine
  • 3-[[[2-[(AMINOIMINOMETHYL)AMINO]-4-THIAZOLYL]METHYL]THIO]-N-(AMINOSULFONYL)PROPANIMIDAMIDE
  • 3-(2-GUANIDINOTHIAZOL-4-YLMETHYLTHIO)-N1-SULFAMOYLPROPIONAMIDE
  • Amfamox
  • Dispmmil
  • Famodine
  • Ifada
  • Peptrax
  • Ulcetrax
  • YM-11170
  • 3-[(2-Diaminomethyleneaminothiazol-4-yl)methylthio]-N-sulfamoylpropionamidine
  • Dispromil
  • N-(Aminosulfonyl)-3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanimidamide
  • Famotidine,N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine
  • Famotidine (125 mg)
  • Famotidine (125 mg)I0E0630.997mg/mg(dr)
  • (Z)-3-(((2-((diaMinoMethylene)aMino)thiazol-4-yl)Methyl)thio)-N'-sulfaMoylpropaniMidaMide
  • FaMotidine (Pepcid)
  • aminosulfonyl)-
  • dispronil
  • famodil
  • famosan
  • famoxal
  • fanosin
  • fibonel
  • ganor
  • gaster
  • gastridan
  • gastridin
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