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Foscarnet sodium

Foscarnet sodium Struktur
63585-09-1
CAS-Nr.
63585-09-1
Englisch Name:
Foscarnet sodium
Synonyma:
FOSCARNET;Foscavir;Triapten;a29622;Foscanet sodium;foscarnet sodim;SODIUM FOSCARNET;FOSCARNET SODIUM;Phenytion Sodium;Foscarnet (sodium salt)
CBNumber:
CB5667480
Summenformel:
CNa3O5P
Molgewicht:
191.95
MOL-Datei:
63585-09-1.mol

Foscarnet sodium Eigenschaften

Schmelzpunkt:
>250°
storage temp. 
Inert atmosphere,Room Temperature
Aggregatzustand
Solid
Farbe
White to off-white
Wasserl?slichkeit
≥ 24.9mg/mL in water
CAS Datenbank
63585-09-1(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Toxizit?t LD50 i.p. in mice: 2000-4000 mmol/kg (Eriksson)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Foscarnet sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Foscamet sodium is a new, injectable antiviral agent useful in the treatment of severe cytomegalovirus retinitis in immunodepressed patients. Foscarnet sodium acts by inhibiting viral-specific DNA polymerases; its side-effects include decreased hemoglobin levels and acute tubular necrosis.

Verwenden

Inhibits viral DNA polymerase and reverse transcriptase.
Foscarnet is the only antiviral approved by the FDA for the treatment of acyclovir-resistant HSV infections, a growing problem in the AIDS population. Foscarnet does not require HSV-encoded thymidine kinase. Foscarnet therapy reduces the healing time, pain, and viral shedding. It is administered intravenously, 40 mg/kg every 8 to 12 hours within 7 to 10 days in patients suspected of having acyclovir-resistant herpes simplex infection. Foscarnet is administered for 10 days. Associated side effects include azotemia secondary to nephrotoxicity, hyperphosphatemia, hypocalcemia, anemia, nausea, vomiting, and genital ulceration. Patients may eventually develop resistant strains. Preliminary trials indicate that topical 1%foscarnet cream may have some benefit for the treatment of acyclovir-resistant mucocutaneous HSV infection in patients with AIDS.

Definition

ChEBI: The trisodium salt of phosphonoformic acid. It is used as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who r quire concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.

Allgemeine Beschreibung

pyrophosphateanalog that inhibits replication in herpesviruses(CMV, HSV, and VSV) and retroviruses (HIV).Foscarnet(Foscavir) is taken up slowly by the cells and does not undergosignificant intracellular metabolism. Foscarnet is a reversible,noncompetitive inhibitor at the pyrophosphatebindingsite of the viral DNA polymerase and RT. Theultimate effect is inhibition of the cleavage of pyrophosphatefrom deoxynucleotide triphosphates and a cessation ofthe incorporation of nucleoside triphosphates into DNA(with the concomitant release of pyrophosphate).Becausethe inhibition is noncompetitive with respect to nucleosidetriphosphate binding, foscarnet can act synergistically withnucleoside triphosphate antimetabolites (e.g., zidovudineand didanosine triphosphates) in the inhibition of viral DNAsynthesis. Foscarnet does not require bioactivation by viralor cellular enzymes and, hence, can be effective against resistantviral strains that are deficient in virally encoded nucleosidekinases.
Foscarnet is a second-line drug for the treatment of retinitiscaused by CMV in patients with AIDS. The drug causesmetabolic abnormalities including increases or decreases inblood Ca2 levels. Nephrotoxicity is common, and this sideeffect precludes the use of foscarnet in other infections causedby herpesvirus or as single-agent therapy for HIV infection.Foscarnet is an excellent ligand for metal ion binding,which undoubtedly contributes to the electrolyte imbalancesobserved with the use of the drug.Hypocalcemia, hypomagnesemia,hypokalemia, and hypophosphatemia and hyperphosphatemiaare observed in patients treated with foscarnet.Side effects such as paresthesias, tetani, seizures, and cardiacarrhythmias may result.

Clinical Use

Foscarnet sodium was approved by the U.S. FDA for the treatment of CMV retinitis in patients with AIDS. In combination with ganciclovir, the results have been promising, even in progressive disease with ganciclovir-resistant strains. Foscarnet sodium also is effective in the treatment of mucocutaneous diseases caused by acyclovir-resistant strains of HSV and VZV in patients with AIDS. Foscarnet sodium is administered IV at 60 mg/kg three times a day for initial therapy and at 90 to 120 mg/kg daily for maintenance therapy. The plasma-half life is 3 to 6 hours. Foscarnet sodium penetrates into the CSF and the eye. The drug is neurotoxic, and common adverse effects include phlebitis, anemia, nausea, vomiting, and seizures. Foscarnet sodium carries the risk of severe hypocalcemia, especially with concurrent use of IV pentamidine. Foscarnet sodium used with zidovudine (ZDV) has an additive effect against CMV and acts synergistically against HIV.

Foscarnet sodium Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Foscarnet sodium Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 230)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 - 03@
sales03@shyrchem.com CHINA 738 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2930 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
Qiuxian Baitai New Material Co., LTD
+8618330912755
sale2@hbyalin.com China 1658 58

63585-09-1()Verwandte Suche:


  • Foscarnet sodium Trisodium phosphonoformate
  • a29622
  • FOSCARNET SODIUM
  • FOSCARNET TRISODIUM SALT
  • dihydroxyphosphinecarboxylicacidoxidetrisodiumsalt
  • phosphinecarboxylicacid,dihydroxy-,oxide,trisodiumsalt
  • phosphonoformic acid trisodium salt
  • SODIUM FOSCARNET
  • trisodium carboxyphosphate
  • trisodium phosphonoformate
  • Foscanet sodium
  • Phenytion Sodium
  • (Sodiooxycarbonyl)phosphonic acid disodium salt
  • Sodiooxycarbonylphosphonic acid disodium salt
  • foscarnet sodim
  • Foscarnet & Foscarnet Sodium
  • Phosphinecarboxylic acid, 1,1-dihydroxy-, 1-oxide, sodium salt (1:3)
  • Sodiumphosphonatoformate
  • trisodium dioxidophosphinecarboxylate oxide
  • trisodium phosphonato carbonate
  • Foscarnet (sodium salt)
  • Foscarnet sodium USP/EP/BP
  • Foscavir
  • Triapten
  • FOSCARNET
  • risodiumphosphonoformate
  • 63585-09-1
  • 63858-09-1
  • CO5PNa3
  • CNa3O5P6H2O
  • CH3O5P3Na
  • CNa3O5P
  • Aliphatics
  • Phosphorylating and Phosphitylating Agents
  • Antiviral
  • Miscellaneous Natural Products
  • API
  • Foscarnet
  • 63585-09-1
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